Zosuquidar Trihydrochloride

CAS : 167465-36-3

Ref. TR-Z700870

Informations sur le produit

• Nom: Zosuquidar Trihydrochloride
• Synonymes: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol Hydrochloride, Zosuquidar Hydrochloride, LY 335979, RS 33295-198, Ly335979, Rs 33295-198, 1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol hydrochloride, Zosuquidar trihydrochloride

Description

Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).
References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 636.99
• Formule: C₃₂H₃₁F₂N₃O₂ClH
• Couleur/Forme: Neat
• InChI: InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31-;;;/m1.../s1
• Code InChI: InChIKey=VQJFFWJUYDGTQZ-FCNWNIDBSA-N
• SMILES: Cl.O[C@@H](COc1cccc2ncccc12)CN1CCN([C@@H]2c3ccccc3[C@@H]3[C@H](c4ccccc42)C3(F)F)CC1