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p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).

MTP3 Ligand-linker Conjugate 1 is a compound formed by the combination of the MTP3 ligand and a linker. It is utilized in the synthesis of PROTAC[MTP3 degrade-1].

Triclopyr (NSC 190671) is a synthetic growth hormone-like herbicide and fungicide with cytotoxicity and mitochondrial damage induced in rat liver

PROTACPI3Kδ degrader-1 is a covalent PI3Kδ-targeting PROTAC degrader that targets lysine, with a DC50 of 3.98 nM. It exhibits potent antiproliferative activity and selective PI3Kδ inhibition (IC50: 8 nM). Additionally, PROTACPI3Kδ degrader-1 effectively degrades p-AKT, induces cell cycle arrest in the G1 phase, and promotes apoptosis and autophagy. It also significantly suppresses tumor growth in the SU-DHL-6 xenograft mouse model.

7-MAD-MDCPT hydrochloride, a camptothecin analogue, serves as the active component in antibody-drug conjugates (ADC).

(S)-Azelastine HCl, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.

HPK1 ligand 3-dimethylph tetrahydropyridine is a Target Protein Ligand-Linker Conjugate. It is utilized in the synthesis of PROTACHPK1 Degrader-4.

CI-936 (MRS-3310) is an orally active A2 agonist with a binding affinity of 25 nM. In preclinical studies, it has demonstrated potent and selective effects, indicating potential antipsychotic efficacy. Additionally, CI-936 inhibits exploratory behavior in mice.

<p>Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.</p>

Mefenacet is an herbicide for rice.

HPK1 ligand 3 is a PROTAC target protein ligand (ligand for target protein for PROTAC) used in the synthesis of PROTAC HPK1 Degrader-4.

MNK1ligand 1 (Compound 5) is an MNK1 ligand used in the synthesis of PROTACMNK1 degrader-1.

Antibacterialagent 281 (Compound 95,186) effectively inhibits the growth of GAS by binding to the ligand-binding pocket of SPs0871, competing with the ligand. It exhibits concentration-dependent growth inhibition against Streptococcus pyogenes (S. pyogenes).

Dimethyl capramide is a biochemical.

GPX4-AUTAC is an autophagy-mediated degrader (AUTAC) targeting GPX4. It consists of the inhibitor ML162-yne, a degradation tag FBnG, and a glycol linker. GPX4-AUTAC facilitates the ubiquitination of GPX4 by the E3 ligase TRAF6 and enhances its interaction with GPX4 and p62, leading to selective autophagy-dependent degradation of GPX4. This compound significantly induces ferroptosis and demonstrates potent anticancer activity in breast cancer cells, patient-derived organoids (PDOs), and MDA-MB-231 tumor xenograft mouse models. It shows strong synergy when used in combination with Sulfasalazine (SAS) or chemotherapy drugs (Paclitaxel or Cisplatin).

Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria.

Antibacterialagent 285 (Compound 3) is a cephalosporin antibiotic. It exhibits significant antibacterial activity against Gram-negative bacteria, with minimum inhibitory concentrations (MIC) of 0.125-0.5 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), 0.125-0.5 μg/mL for Klebsiella pneumoniae (CRE), and 0.125-2 μg/mL for Pseudomonas aeruginosa (CRPA). Antibacterialagent 285 can be utilized in bacterial infection research, including studies on complicated urinary tract infections (cUTI) and kidney infections.

BRD4/FKBP12 degrader-2 (a1d) is a BRD4/FKBP12 degrader with anticancer activity.

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.

N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.