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Se termine le 31 déc.( plus que 8 jours )
EphB1-IN-1
CAS :EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formule :C16H12Cl2N4O2Couleur et forme :SolidMasse moléculaire :363.2NBI-921352
CAS :NBI-921352 (XEN901) is a potent NaV1.6 sodium channel inhibitor, effectively treating epilepsy without severe side effects.Formule :C22H25FN4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.59Udifitimod
CAS :Udifitimod (BMS-986166) is a potent, selective, and orally active modulator of the S1P1R receptor, showing potential for research in autoimmune diseases.Formule :C25H33NO2Couleur et forme :SolidMasse moléculaire :379.54Z-VRPR-FMK
CAS :Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.Formule :C31H49FN10O6Couleur et forme :SolidMasse moléculaire :676.78Adhesamine
CAS :Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Formule :C24H32Cl4N8O2S2Couleur et forme :SolidMasse moléculaire :670.51PNU-101603
CAS :<p>PNU-101603, a Sutezolid metabolite, effective against TB including drug-resistant strains, works solo or with SQ109.</p>Formule :C16H20FN3O4SCouleur et forme :SolidMasse moléculaire :369.41Z-LEVD-FMK
CAS :Z-LEVD-FMK is a caspase-4 inhibitor with anti-cancer activity, capable of eliminating LPS-induced GCLC protein degradation.Formule :C31H45FN4O10Couleur et forme :SolidMasse moléculaire :652.71SID-852843
CAS :SID-852843, WNV NS2B-NS3 protease inhibitor, IC50: 0.105 μM, useful in viral infection studies.Formule :C17H15N3O5SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :373.38BACE2-IN-1
CAS :<p>BACE2-IN-1, a potent BACE2 inhibitor characterized by its exceptional selectivity and a Ki value of 1.6 nM, is utilized in the investigation of Type 2 Diabetes.</p>Formule :C36H38F3N3O3Couleur et forme :SolidMasse moléculaire :617.7Etbicyphat
CAS :Etbicyphat: potent GABA(A) antagonist, induces epileptiform activity, binds to GABA/benzodiazepine receptors.Formule :C6H11O4PCouleur et forme :SolidMasse moléculaire :178.12Paquinimod
CAS :Paquinimod (ABR 25757) is a S100A9 inhibitor preventing S100A9 binding to TLR-4.Formule :C21H22N2O3Degré de pureté :98.04% - 99.79%Couleur et forme :SolidMasse moléculaire :350.41ACT-606559
ACT-606559, a metabolite of ACT451840, is a novel chemical compound exhibiting antimalarial properties. It is utilized in malaria research.Formule :C47H52N6O3Couleur et forme :SolidMasse moléculaire :748.95EGFR-IN-25
CAS :EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.Formule :C34H43N9O2Couleur et forme :SolidMasse moléculaire :609.76EGFR-IN-21
CAS :EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formule :C36H44BrN10O2PCouleur et forme :SolidMasse moléculaire :759.68EGFR-IN-23
CAS :EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.Formule :C36H44BrN10O3PCouleur et forme :SolidMasse moléculaire :775.68EGFR-IN-28
CAS :EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .Formule :C31H39BrN10O3SCouleur et forme :SolidMasse moléculaire :711.68EGFR-IN-29
CAS :EGFR-IN-29 is a potent EGFR inhibitor.Formule :C36H46BrN8O2PCouleur et forme :SolidMasse moléculaire :733.68RAD51-IN-4
CAS :RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formule :C31H34FN5O5S2Couleur et forme :SolidMasse moléculaire :639.76EGFR-IN-30
CAS :EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, <1 nM WT/mutants) with potential in cancer research.Formule :C28H33BrN7O2PCouleur et forme :SolidMasse moléculaire :610.49JNK-1-IN-1
CAS :JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formule :C24H22N6SCouleur et forme :SolidMasse moléculaire :426.54Oxyphenisatin acetate
CAS :<p>Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.</p>Formule :C24H19NO5Degré de pureté :98% - 99.35%Couleur et forme :SolidMasse moléculaire :401.41PI3Ka-IN-5
CAS :PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Formule :C30H35N9O5Couleur et forme :SolidMasse moléculaire :601.66IDO1-IN-17
CAS :IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Formule :C28H32BrClFN5O2Couleur et forme :SolidMasse moléculaire :604.94STAT3-IN-7
CAS :STAT3-IN-7, an orally active aryl sulfonamido azetidine compound, serves as a STAT3 inhibitor with anticancer activities.Formule :C30H26F5N5O4SCouleur et forme :SolidMasse moléculaire :647.62(S)-HH2853
CAS :(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Formule :C31H36F3N7O3Degré de pureté :97.18% - 99.74%Couleur et forme :SolidMasse moléculaire :611.66(R)-HH2853
CAS :(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Formule :C31H36F3N7O3Degré de pureté :97.53% - 98.85%Couleur et forme :SolidMasse moléculaire :611.66ROCK2-IN-5
ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.Formule :C23H25N3O5SCouleur et forme :SolidMasse moléculaire :455.53PI3K-IN-28
CAS :PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.Formule :C26H16F9N3O3S2Couleur et forme :SolidMasse moléculaire :653.54AX20017
CAS :<p>AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.</p>Formule :C13H16N2O2SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :264.34MptpB-IN-1
CAS :MptpB-IN-1: orally active, potent MptpB inhibitor; reduces drug-resistant tuberculosis.Formule :C17H11Cl2NO4Couleur et forme :SolidMasse moléculaire :364.18FGFR4-IN-8
CAS :FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Formule :C32H34Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.56ThrRS-IN-3
ThrRS-IN-3: Potent inhibitor of Salmonella enterica ThrRS, IC50 = 19 nM, Kd = 34 nM, with antibacterial effects.Formule :C31H30Cl2N6O5Couleur et forme :SolidMasse moléculaire :637.51SMTIN-T140
CAS :SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02C16-K-cBB1
C16-K-cBB1: potent, selective MRSA killer; MIC 1µg/mL, low hemolysis, works in 120 min at 12.5µg/mL.Formule :C33H58ClN5O5SCouleur et forme :SolidMasse moléculaire :672.36EGFR-IN-61
CAS :EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 & H1975 cell growth (IC50: 2.14 & 1.82 μM).Formule :C33H37ClN8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.15STAT6-IN-1
CAS :STAT6-IN-1: STAT6 inhibitor, IC50=0.028 µM, targets SH2 domain, for allergy and cancer research.Formule :C33H37IN3O7PCouleur et forme :SolidMasse moléculaire :745.54Enclomiphene citrate
CAS :Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic propertyFormule :C32H36ClNO8Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :598.08Mebanazine
CAS :<p>Mebanazine, a potent monoamine oxidase (MAO) inhibitor, is utilized in depression research.</p>Formule :C8H12N2Couleur et forme :SolidMasse moléculaire :136.19DS69910557
DS69910557: potent hPTHR1 antagonist, IC50 0.08 μM, oral, for hyperparathyroidism & osteoporosis research.Formule :C32H33Cl2FN4O3Couleur et forme :SolidMasse moléculaire :611.53FGF22-IN-1
CAS :<p>FGF22-IN-1 is a CD4 N-terminal immunoglobulin variable region-like structural domain (CD4 D1) inhibitor that suppresses the immune response.</p>Formule :C14H11N3OSDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :269.32EZH2-IN-14
CAS :<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69USP7-IN-10
CAS :<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05MAT2A-IN-9
CAS :<p>MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.</p>Formule :C14H8ClF3N4ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :340.69GSK1790627
CAS :GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Formule :C24H21FIN5O3Couleur et forme :SolidMasse moléculaire :573.36FLT3-IN-18
CAS :FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.Formule :C26H36N8OCouleur et forme :SolidMasse moléculaire :476.62PHGDH-IN-3
CAS :PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.Formule :C24H18FN3O4S2Degré de pureté :97.24% - 99.1%Couleur et forme :SolidMasse moléculaire :495.55FGFR3-IN-4
CAS :FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.Formule :C26H24ClN7OCouleur et forme :SolidMasse moléculaire :485.97FGFR3-IN-5
CAS :<p>FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.</p>Formule :C24H24FN7O3Couleur et forme :SolidMasse moléculaire :477.49ACT-777991
CAS :ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48HPK1-IN-33
CAS :HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.Formule :C18H16ClFN6Couleur et forme :SolidMasse moléculaire :370.81
