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Se termine le 31 déc.( plus que 8 jours )
HPK1-IN-33
CAS :HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.Formule :C18H16ClFN6Couleur et forme :SolidMasse moléculaire :370.81BAY1125976
CAS :<p>BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)</p>Formule :C23H21N5ODegré de pureté :99.28% - ≥98%Couleur et forme :SolidMasse moléculaire :383.45PI3K-IN-36
CAS :PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).Formule :C30H36F2N8OCouleur et forme :SolidMasse moléculaire :562.66USP22-IN-1
CAS :<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Formule :C22H18N4Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :338.41SLU-PP-915
CAS :SLU-PP-915, ERR agonist, EC50 ~400 nM for ERRα/β/γ, may aid oxidative metabolism & heart health.Formule :C17H13BFNO3SCouleur et forme :SolidMasse moléculaire :341.16EGFR-IN-69
CAS :EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formule :C31H37Cl2N7O3SCouleur et forme :SolidMasse moléculaire :658.64EGFR-IN-70
EGFR-IN-70: potent EGFR inhibitor, IC50 of 23.6 nM (LR/TM/CS), 307.5 nM (WT), anti-proliferative, inhibits EGFR phosphorylation, for cancer research.Formule :C31H36ClN5O5SCouleur et forme :SolidMasse moléculaire :626.17BMS-986339
CAS :BMS-986339: oral, potent FXR agonist; binds to His298/ASN287; for PBC, PSC, NASH, anti-fibrosis research.Formule :C35H41F4N3O4Couleur et forme :SolidMasse moléculaire :643.71LabMol-301
CAS :LabMol-301 blocks NS5 RdRp/NS2B-NS3pro (IC50: 0.8/7.4µM), protects cells from ZIKV death.Formule :C18H16N6Couleur et forme :SolidMasse moléculaire :316.36LY2828360
CAS :LY2828360: CB2 agonist, Ki=40.3 nM; biases CB2 over CB1 with EC50s of 20.1 nM and >100 μM.Formule :C22H27ClN6ODegré de pureté :98.45% - 99.51%Couleur et forme :SolidMasse moléculaire :426.94HadAB-IN-1
CAS :HadAB-IN-1: potent TB research chemical; IC50 = 0.03μM; inhibits HadAB, affecting Mtb mycolic acid synthesis.Formule :C19H17BrClN3O3SCouleur et forme :SolidMasse moléculaire :482.78CDK7-IN-20
CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.Formule :C30H26N6O3Couleur et forme :SolidMasse moléculaire :518.57SOS1-IN-15
CAS :<p>SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.</p>Formule :C28H27F3N6O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :536.548EGFR-IN-73
CAS :EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].Formule :C19H17ClFN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.81FUBP1-IN-2
CAS :FUBP1-IN-2 hinders FUBP1, affects c-Myc and p21 expression, and depletes polyamines.Formule :C26H26ClN3O4Couleur et forme :SolidMasse moléculaire :479.96HDAC-IN-49
<p>HDAC-IN-49: potent, broad HDAC inhibitor; IC50s: 10-1880 nM for HDAC1-6; strong anti-leukemic, low toxicity to healthy cells.</p>Formule :C26H27FN4O4Couleur et forme :SolidMasse moléculaire :478.52CU-CPT-9a
CAS :<p>CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-</p>Formule :C17H15NO2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :265.31EGFR-IN-74
EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.Formule :C32H28BrF3N6O4SCouleur et forme :SolidMasse moléculaire :729.57FOXM1-IN-1
FOXM1-IN-1: Potent inhibitor of FOXM1, IC50=2.65µM, hinders cell growth & lowers FOXM1, PLK1, CDC25B levels.Formule :C23H30ClNO3Couleur et forme :SolidMasse moléculaire :403.94MMP-1-IN-1
MMP-1-IN-1 is a highly potent MMP-1 inhibitor with an IC 50 of 0.034 μM .Formule :C14H17ClN2O3Couleur et forme :SolidMasse moléculaire :296.75LRRK2-IN-7
CAS :LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formule :C24H26N6ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :414.5hCAII-IN-9
CAS :<p>hCAII-IN-9 inhibits hCA II/IX/XII with IC50s of 1.18, 0.17, 2.99 μM; not BBB permeable.</p>Formule :C15H16ClN3O5S2Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :417.89EGFR-IN-75
EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.Formule :C10H6N6S2Couleur et forme :SolidMasse moléculaire :274.32HDAC-IN-50
CAS :HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.Formule :C31H41N7O4Couleur et forme :SolidMasse moléculaire :575.7Elimusertib
CAS :Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormule :C20H21N7ODegré de pureté :98.72% - 99.84%Couleur et forme :SolidMasse moléculaire :375.43NSC 295642
CAS :<p>NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.</p>Formule :C15H14ClCuN3S2Couleur et forme :SolidMasse moléculaire :399.42HDAC-IN-51
HDAC-IN-51 is an HDAC inhibitor.Formule :C27H24N4O2Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :436.51BSJ-04-122
CAS :BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formule :C15H12ClN5ODegré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :313.74SMYD3-IN-2
SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.Formule :C26H21BrN2O4Couleur et forme :SolidMasse moléculaire :505.36BChE-IN-15
<p>BChE-IN-15 is a compound characterized as a pseudo-irreversible, covalent inhibitor of butyrylcholinesterase (BChE), demonstrating potent activity with an</p>Formule :C22H33N3O2Couleur et forme :SolidMasse moléculaire :371.52PRMT6-IN-3
CAS :PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.Formule :C19H26N4O2SDegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :374.5HPK1-IN-31
HPK1-IN-31 inhibitor with an IC 50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy .Formule :C30H33N7O3Couleur et forme :SolidMasse moléculaire :539.63BuChE-IN-7
<p>BuChE-IN-7: selective hBuChe & eqBuChe inhibitor, IC50s 40/80 nM, boosts cognition & memory, and penetrates blood-brain barrier.</p>Formule :C25H34N2O2Couleur et forme :SolidMasse moléculaire :394.55RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54Ficonalkib
CAS :Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formule :C29H39N7O3SCouleur et forme :SolidMasse moléculaire :565.737-Methylguanosine
CAS :7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Formule :C11H16N5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :298.28Fulzerasib
CAS :<p>Fulzerasib is an orally active KRAS G12C inhibitor that covalently binds to cysteine residue on the protein, thereby inhibiting the growth of KRAS G12C mutant</p>Formule :C32H30ClFN6O4Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :617.07LONP1-IN-2
CAS :LONP1-IN-2: Potent LONP1 inhibitor, IC50=0.187μM; weak on 20S proteasome (>10μM); for cancer research.Formule :C16H27BN4O4Couleur et forme :SolidMasse moléculaire :350.22DOCK2-IN-1
CAS :<p>DOCK2-IN-1, a CPYPP analogue, inhibits DOCK2 (IC50=19.1μM), reversibly binds DHR-2, and suppresses lymphocyte chemotaxis and T cell activation.</p>Formule :C16H11ClN2O2Couleur et forme :SolidMasse moléculaire :298.72EAPB 02303
CAS :<p>EAPB 02303, a microtubule inhibitor, induces mitotic arrest, spindle impairment, apoptosis, and has antitumor effects, enhancing Paclitaxel.</p>Formule :C17H14N4O2Couleur et forme :SolidMasse moléculaire :306.32RGB-286638
CAS :RGB-286638 inhibits multiple CDKs and GSK-3β, TAK1, Jak2, MEK1 with IC50s as low as 1-54 nM.Formule :C29H37Cl2N7O4Couleur et forme :SolidMasse moléculaire :618.55Piperazine
CAS :<p>Piperazine (1,4-Diazacyclohexane), a gamma-aminobutyric acid (GABA) agonist, serves as a crucial building block and core component in a wide range of marketed drugs known for their varied pharmacological activities.</p>Formule :C4H10N2Couleur et forme :SolidMasse moléculaire :86.14Nifuroxime
CAS :Nifuroxime, an anti-infective agent, is utilized in researching fungal infections.Formule :C5H4N2O4Couleur et forme :SolidMasse moléculaire :156.1Yadanzigan
CAS :<p>Yadanzigan(YDZG),a specific NLRP3 inhibitor, attenuates the NF-κB pathway and reactive oxygen species generation, while enhancing TRIM31, anti-inflammatory.</p>Formule :C26H38O14Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :574.57Tozadenant
CAS :Tozadenant (SYN115) is an adenosine A2A receptor antagonist(Ki of 11.5 nM and 6 nM on human and rhesus,respectively)Formule :C19H26N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.5Stigmane B
<p>Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.</p>Formule :C21H30O4Couleur et forme :SolidMasse moléculaire :346.46BChE-IN-11
CAS :BChE-IN-11: potent, selective, non-competitive BChE inhibitor; IC50=2.1μM; used in AD research.Formule :C22H18O4Couleur et forme :SolidMasse moléculaire :346.38Praelolide
Praelolide activates Nrf2, hinders osteoclastogenesis/ROS, binds Keap1 noncovalently, may aid bone disease research.Formule :C28H35ClO12Couleur et forme :SolidMasse moléculaire :599.02Wikstrol A
CAS :Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.Formule :C30H22O10Couleur et forme :SolidMasse moléculaire :542.49Laburnetin
CAS :Laburnetin: an isoflavone antibacterial, combats fungi/S. vesicarium, boosts MRSA methicillin susceptibility, used in pest control.Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.35
