CAS 1004316-88-4

Cobicistat

Descrizione:

Cobicistat è un composto farmaceutico utilizzato principalmente come potenziatore dei farmaci antiretrovirali nel trattamento dell'HIV. È classificato come un inibitore selettivo del citocromo P450 3A (CYP3A), che aumenta l'efficacia di altri farmaci inibendo il loro metabolismo, aumentando così le loro concentrazioni plasmatiche. Cobicistat è un solido cristallino bianco a bianco sporco ed è solubile in solventi organici come metanolo e dimetilsolfossido, ma ha una solubilità limitata in acqua. La sua formula molecolare è C13H18N4O2S e ha un peso molecolare di circa 278,37 g/mol. Il composto viene tipicamente somministrato per via orale ed è spesso incluso in terapie combinate per migliorare la farmacocinetica di altri agenti antiretrovirali. Cobicistat non è un antivirale di per sé, ma gioca un ruolo cruciale nell'ottimizzazione dei regimi terapeutici per i pazienti infetti da HIV. Come per qualsiasi farmaco, è essenziale considerare i potenziali effetti collaterali e le interazioni farmacologiche quando utilizzato in concomitanza con altre terapie.

Formula: C₄₀H₅₃N₇O₅S₂

InChI: InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1

InChI key: InChIKey=ZCIGNRJZKPOIKD-CQXVEOKZSA-N

SMILES: [C@@H](CC1=CC=CC=C1)(NC([C@H](CCN2CCOCC2)NC(N(CC=3N=C(C(C)C)SC3)C)=O)=O)CC[C@H](CC4=CC=CC=C4)NC(OCC5=CN=CS5)=O

Sinonimi:

• Cobicistat
• Tybost
• GS 9350
• 2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)-
• (3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester
• Cobicistat (GS-9350)
• thiazol-5-ylMethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)Methyl)-3-Methylureido)-4-MorpholinobutanaMido)-1,6-diphenylhexan-2-ylcarbaMate
• Thiazol-5-ylmethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-mor
• GS9350
• Cobiclstat
• Cobicistat D8

1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[(2S)-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}-4-(morpholin-4-yl)butanamido]-1,6-diphenylhexan-2-yl]carbamate

CAS: 1004316-88-4

Formula: C₄₀H₅₃N₇O₅S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 776.0227

Ref: IN-DA0001ZB

Cobicistat

CAS: 1004316-88-4

Cobicistat

Purezza: ≥95%

Peso molecolare: 776.02g/mol

Ref: 54-BUP09602

cis-Capsaicin-d3

CAS: 1004316-88-4

Formula: C₁₈H₂₄NO₃D₃

Colore e forma: White To Off-White Solid

Peso molecolare: 308.44

Ref: 4Z-C-875

Cobicistat-d8

CAS: 1004316-88-4

Formula: C₄₀H₄₅D₈N₇O₅S₂

Colore e forma: White To Off-White Solid

Peso molecolare: 784.08

Ref: 4Z-C-122002

Cobicistat

CAS: 1004316-88-4

Formula: C₄₀H₅₃N₇O₅S₂

Colore e forma: Off-White Solid

Peso molecolare: 776.03

Ref: 4Z-C-122001

Cobicistat

CAS: 1004316-88-4

Cobicistat (GS-9350): A carbamate, thiazole derivative, and CYP3A inhibitor used to boost anti-HIV drugs for treating HIV.

Formula: C₄₀H₅₃N₇O₅S₂

Purezza: 97.36% - 99.62%

Colore e forma: Solid

Peso molecolare: 776.02

Ref: TM-T6246

Cobicistat

Prodotto controllato

CAS: 1004316-88-4

Stability Hygroscopic
Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

Formula: C₄₀H₅₃N₇O₅S₂

Colore e forma: Neat

Peso molecolare: 776.02

Ref: TR-C633150

Cobicistat

CAS: 1004316-88-4

Cobicistat is an inhibitor of human cytochrome P450 3A enzymes (CYP) with no antiviral activity. Cobicistat is used in the treatment of HIV-1 infection, as an alternative to ritonavir, to increase the half-life of antiviral medications (von Hentig, 2016). Cobicistat acts as a booster by selectively inhibiting the hepatic degradation of the drugs, for example, in the pharmacological regime against HIV-1, which often includes protease inhibitors, such as, darunavir, atazanavir, and lopinavir, or the integrase inhibitor elvitegravir (Deeks, 2014).

Formula: C₄₀H₅₃N₇O₅S₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 776.03 g/mol

Ref: 3D-FM40808

Cobicistat-d8

Prodotto controllato

CAS: 1004316-88-4

Applications Isotope labelled analogue of Cobicistat (C633150), a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

Formula: C₄₀D₈H₄₅N₇O₅S₂

Colore e forma: Neat

Peso molecolare: 784.072

Ref: TR-C633152