CAS 1009298-09-2

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metossibenzenometanolo

Descrizione:

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metossibenzenometanolo, con numero CAS 1009298-09-2, è un composto organico complesso caratterizzato dalla sua struttura a più anelli, che include un nucleo di pirido-pirimidina e un gruppo benzene sostituito da metossi. Questo composto presenta un gruppo morfolina, contribuendo alla sua potenziale attività biologica, in particolare in chimica medicinale. La presenza di più gruppi funzionali suggerisce che potrebbe mostrare diverse reattività chimiche e proprietà di solubilità. La sua estereoquimica, indicata dalla configurazione (3S), implica disposizioni spaziali specifiche che potrebbero influenzare la sua interazione con obiettivi biologici. Le potenziali applicazioni del composto possono includere ruoli come agente farmaceutico, date le sue caratteristiche strutturali che sono spesso associate a molecole bioattive. Tuttavia, sarebbero necessari studi dettagliati sulla sua farmacocinetica, tossicità ed efficacia per comprendere appieno le sue caratteristiche e i potenziali usi in contesti terapeutici.

Formula: C₂₅H₃₁N₅O₄

InChI: InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1

InChI key: InChIKey=KVLFRAWTRWDEDF-IRXDYDNUSA-N

SMILES: C[C@@H]1N(C=2C3=C(N=C(N2)N4[C@@H](C)COCC4)N=C(C=C3)C5=CC(CO)=C(OC)C=C5)CCOC1

Sinonimi:

• 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
• Azd 8055
• Azd8055
• Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-
• Ccg 168
• Lm1148
• Nvp-Ccg 168
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD 8055
• AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• (5-{2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
• AZD8055,AZD-8055
• AZD8055, >=98%
• {5-[2,4-Bis-(3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol
• AZD-8055 USP/EP/BP
• [5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[
• (5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate
• AZD-8055; AZD8055; AZD 8055.
• Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester
• CS-1935

Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-

CAS: 1009298-09-2

Formula: C₂₅H₃₁N₅O₄

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 465.5447

Ref: IN-DA000383

AZD-8055

CAS: 1009298-09-2

AZD-8055

Purezza: ≥95%

Peso molecolare: 465.54g/mol

Ref: 54-BUP13178

Azd-8055

CAS: 1009298-09-2

Azd-8055

Purezza: 97%

Peso molecolare: 465.54g/mol

Ref: 54-OR1024083

AZD-8055

CAS: 1009298-09-2

AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.

Formula: C₂₅H₃₁N₅O₄

Purezza: 98% - 99.69%

Colore e forma: Solid

Peso molecolare: 465.54

Ref: TM-T1859

AZD-8055

CAS: 1009298-09-2

Purezza: ≥ 95.0%

Colore e forma: Yellow powder or solid

Ref: 7W-GW4102

AZD8055

Prodotto controllato

CAS: 1009298-09-2

Applications A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Dual mTORC1/C2 inhibitor
References Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);

Formula: C₂₅H₃₁N₅O₄

Colore e forma: Neat

Peso molecolare: 465.54

Ref: TR-A808130

AZD 8055

CAS: 1009298-09-2

A selective and ATP-competitive inhibitor of mTOR kinase with an IC50 value of 0.8 nM. Inhibits growth of a range of tumor types in vivo and in vitro. Effective in preventing and treating endocrine-resistant breast cancer. Causes autophagy in H838 and A549 cells.

Formula: C₂₅H₃₁N₅O₄

Purezza: Min. 95%

Peso molecolare: 465.54 g/mol

Ref: 3D-FA18068