CAS 10106-41-9

17-α,21-diidrossi-16-α-metilpregna-1,4,9(11)-triene-3,20-dione 21-acetato

Descrizione:

17-α,21-diidrossi-16-α-metilpregna-1,4,9(11)-triene-3,20-dione 21-acetato, comunemente noto come acetato di dexametazone, è un glucocorticoide sintetico con proprietà anti-infiammatorie e immunosoppressive. È caratterizzato dalla sua struttura steroidea, che include un nucleo di ciclopentanoperidrofenantrene, modificato con gruppi idrossilici nelle posizioni 17 e 21 e un gruppo acetato nella posizione 21. Questo composto mostra alta potenza e una lunga durata d'azione, rendendolo efficace nel trattamento di varie condizioni come allergie, malattie autoimmuni e alcuni tumori. L'acetato di dexametazone è spesso somministrato tramite iniezione o formulazioni topiche, ed è noto per la sua capacità di sopprimere la risposta immunitaria e ridurre l'infiammazione. I suoi effetti farmacologici sono mediati attraverso il recettore dei glucocorticoidi, portando a modifiche nell'espressione genica. Come altri corticosteroidi, può avere effetti collaterali, inclusi potenziali impatti sul metabolismo, sulla funzione immunitaria e sull'equilibrio elettrolitico, richiedendo un attento monitoraggio durante l'uso terapeutico.

Formula: C₂₄H₃₀O₅

InChI: InChI=1/C24H30O5/c1-14-11-20-18-6-5-16-12-17(26)7-9-22(16,3)19(18)8-10-23(20,4)24(14,28)21(27)13-29-15(2)25/h7-9,12,14,18,20,28H,5-6,10-11,13H2,1-4H3/t14-,18-,20+,22+,23+,24+/m1/s1

InChI key: InChIKey=AAPZMQVULRVUEU-PYAFTSMNSA-N

SMILES: C[C@@]12[C@]([C@]3(C(=CC1)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])(C[C@@H](C)[C@@]2(C(COC(C)=O)=O)O)[H]

Sinonimi:

• (16Alpha)-17-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4,9(11)-Trien-21-Yl Acetate
• (16α)-21-(Acetyloxy)-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16α-methyl-, 21-acetate
• Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-17-hydroxy-16-methyl-, (16α)-
• "17,21-Dihydroxy-16-β-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate"
• Dexamethasone impurity H
• 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• 2-((8S,10S,13S,14S,16R,17R)-17
• Dexamethasone Acetate Impurity H
• 17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• 21-Acetoxy-17-hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione
• 17-alpha,21-dihydroxy-16-alpha-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• Dexamethasone Acetate Impurity 8（Dexamethasone Acetate EP Impurity H）
• Dexamethasone Acetate EP Impurity H
• Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16.alpha.-methyl-, 21-acetate
• Pregnatriene acetate
• Dexamethasone EP Imp H
• 17α, 21-dihydroxy-16α-methyl-1, 4 ,9(11)-pregnatriene-3, 20-dione 21-acetate
• 17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE
• 21-Acetyloxy-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• 2-((10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
• Dexamethasone impurity 2/Dexamethasone EP Impurity H
• 17-hydroxy-16α-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• Dexamethasone Impurity 8(Dexamethasone EP Impurity H)

Dexamethasone EP Impurity H

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Colore e forma: Pale Yellow Solid

Peso molecolare: 398.50

Ref: 4Z-D-3633

17-Hydroxy-16α-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl Acetate

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Colore e forma: Neat

Peso molecolare: 398.49

Ref: 86-MM0445.08

17,21-Dihydroxy-16a-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate

Prodotto controllato

CAS: 10106-41-9

Applications 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate is an intermediate in the synthesis of Mometasone Furoate (M490000), a tropical corticosteroid used as an anti-inflammatory agent.
References Spangler, M., et al.: Chromatograph., 54, 329 (2001); Reeves, E.K., et al.: Bioorg. Med. Chem., 21, 2241 (2013);

Formula: C₂₄H₃₀O₅

Colore e forma: White To Light Yellow

Peso molecolare: 398.49

Ref: TR-D453275

16α-Methyl-d3-9,11-dehydro Prednisolone 21-Acetate

Prodotto controllato

CAS: 10106-41-9

Applications Intermediate in the preparation of non-hormonal steroid modulators.

Formula: C₂₄H₂₇D₃O₅

Colore e forma: Neat

Peso molecolare: 401.51

Ref: TR-M295312

Dexamethasone Acetate EP Impurity H

CAS: 10106-41-9

Formula: C₂₄H₃₀O₅

Peso molecolare: 398.5

Ref: ST-EA-CP-D17038

17-α,21-Dihydroxy-16-a-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate

Prodotto controllato

CAS: 10106-41-9

Please enquire for more information about 17-alpha,21-Dihydroxy-16-a-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₄H₃₀O₅

Purezza: Min. 95%

Peso molecolare: 398.49 g/mol

Ref: 3D-FA46287