CAS 1033805-22-9

4-[2-Amino-6-[(1R)-1-[4-cloro-2-(3-metil-1H-pirazol-1-il)fenil]-2,2,2-trifluoroetossi]-4-pirimidinil]-L-fenilalanina etil estere

Descrizione:

La sostanza chimica nota come 4-[2-Amino-6-[(1R)-1-[4-cloro-2-(3-metil-1H-pirazol-1-il)fenil]-2,2,2-trifluoroetossi]-4-pirimidinil]-L-fenilalanina etil estere, con numero CAS 1033805-22-9, è un composto organico complesso caratterizzato dalla sua struttura multifunzionale. Presenta un anello di pirimidina, che è un eterociclo aromatico a sei membri contenente atomi di azoto, e un gruppo di amminoacido, specificamente L-fenilalanina, che contribuisce alla sua attività biologica. La presenza di un gruppo trifluoroetossido e di un anello fenilico cloro-sostituito indica un potenziale per interazioni significative nei sistemi biologici, influenzando possibilmente le sue proprietà farmacologiche. Inoltre, il composto contiene un gruppo di pirazolo, noto per le sue diverse attività biologiche, inclusi effetti anti-infiammatori e anti-cancerogeni. Il gruppo funzionale estere etilico suggerisce che il composto possa mostrare una lipofilia migliorata, influenzando potenzialmente la sua assorbimento e distribuzione nei sistemi biologici. In generale, la struttura intricata di questo composto suggerisce che potrebbe essere di interesse nella chimica medicinale e nello sviluppo di farmaci.

Formula: C₂₇H₂₆ClF₃N₆O₃

InChI: InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1

InChI key: InChIKey=MDSQOJYHHZBZKA-GBXCKJPGSA-N

SMILES: [C@H](OC=1C=C(N=C(N)N1)C2=CC=C(C[C@@H](C(OCC)=O)N)C=C2)(C(F)(F)F)C3=C(C=C(Cl)C=C3)N4C=CC(C)=N4

Sinonimi:

• (2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester
• 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-<span class="text-smallcaps">L</span>-phenylalanine ethyl ester
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester
• Lx 1032
• Lx 1606
• Lx1032
• Telotristat ethyl
• Xermelo
• 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester
• L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester

LX-1606 Hippurate

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Purezza: %

Colore e forma: Solid

Peso molecolare: 574.9819

Ref: IN-DA008THI

Telotristat ethyl

CAS: 1033805-22-9

Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Formula: C₂₇H₂₆ClF₃N₆O₃

Purezza: 98% - 99.89%

Colore e forma: White Solid

Peso molecolare: 574.98

Ref: TM-T11897

Telotristat Ethyl

CAS: 1033805-22-9

Telotristat Ethyl

Purezza: 98%

Peso molecolare: 574.98g/mol

Ref: 54-PC108553

Telotristat ethyl

CAS: 1033805-22-9

Telotristat ethyl

Purezza: ≥95%

Peso molecolare: 574.98g/mol

Ref: 54-BUP09452

Ethyl Telotristat

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Peso molecolare: 574.99

Ref: 4Z-T-135003

Telotristat Ethyl

Prodotto controllato

CAS: 1033805-22-9

Applications Telotristat Ethyl can be used in biological study of serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation.
References Welford, R. W. D., et al.: Scientific Reports, 6, 30059 (2016)

Formula: C₂₇H₂₆ClF₃N₆O₃

Colore e forma: Neat

Peso molecolare: 574.98

Ref: TR-T017098

(S)-Ethyl2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol -1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate

CAS: 1033805-22-9

Telotristat ethyl is a pharmacological treatment for carcinoid syndrome, which is caused by the release of serotonin from enterochromaffin cells in the intestine. Telotristat ethyl inhibits serotonin release by reversibly inhibiting serotonin release from enterochromaffin cells and other cell types that express 5-HT4 receptors. This drug has no effect on the release of histamine or acetylcholine and does not cross the blood-brain barrier. Telotristat ethyl has shown long-term efficacy in people with carcinoid syndrome and minimal toxicity profiles. The most common side effects are diarrhoea, nausea, vomiting, abdominal pain, headache, and dizziness.

Formula: C₂₇H₂₆ClF₃N₆O₃

Purezza: Min. 95%

Peso molecolare: 574.98 g/mol

Ref: 3D-FE157240

Ethyl Telotristat

CAS: 1033805-22-9

Formula: C₂₇H₂₆ClF₃N₆O₃

Peso molecolare: 574.99

Ref: ST-EA-CP-T258000