CAS 104344-23-2

Fumarato di bisoprololo

Descrizione:

Fumarato di bisoprololo è un bloccante selettivo del recettore adrenergico beta-1 utilizzato principalmente nella gestione dell'ipertensione e dell'insufficienza cardiaca. È una polvere cristallina bianca o bianco-giallastra che è solubile in acqua e metanolo, ma meno solubile in solventi organici come cloroformio ed etere. La sostanza è caratterizzata dalla sua capacità di ridurre la frequenza cardiaca e la contrattilità miocardica, rendendola efficace nella riduzione della pressione sanguigna e nel miglioramento della funzione cardiaca. Fumarato di bisoprololo è tipicamente somministrato per via orale ed è noto per la sua emivita relativamente lunga, che consente una somministrazione una volta al giorno. La forma di sale fumarato ne migliora la stabilità e la solubilità, facilitando una migliore assorbimento nel tratto gastrointestinale. Come altri beta-bloccanti, può avere effetti collaterali come affaticamento, vertigini e bradicardia, e deve essere usato con cautela in pazienti con asma o determinate condizioni cardiovascolari. In generale, Fumarato di bisoprololo è un importante agente terapeutico nella medicina cardiovascolare, contribuendo a migliorare i risultati dei pazienti in varie condizioni legate al cuore.

Formula: C₁₈H₃₁NO₄C₄H₄O₄

InChI: InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=RZPZLFIUFMNCLY-WLHGVMLRSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(COCCOC(C)C)C=C1.C(=C/C(O)=O)\C(O)=O

Sinonimi:

• (2R)-1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
• 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (salt)
• 1-(Propan-2-Ylamino)-3-(4-{[2-(Propan-2-Yloxy)Ethoxy]Methyl}Phenoxy)Propan-2-Ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt)
• Bisoprolol Fumarate
• Bisoprolol fumerate
• Concor
• Detensiel
• Emcor
• Emd 33512
• Emvoncor
• Eurtadal
• Isoten
• Maintate
• Monocor
• Soprol

Bisoprolol Hemifumarate

CAS: 104344-23-2, 66722-44-9

Formula: C₁₈H₃₁NO₄C₄H₄O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 383.49

Ref: 3B-B3994

Bisoprolol Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 104344-23-2

Colore e forma: Single Solution

Ref: 61-AMP0460.08-01

Bisoprolol Fumarate

CAS: 104344-23-2

Colore e forma: Neat

Ref: 61-FOR0460.08

BISOPROLOL FOR SYSTEM SUITABILITY CRS

CAS: 104344-23-2

BISOPROLOL FOR SYSTEM SUITABILITY CRS

Formula: C₄₀H₆₆N₂O₁₂

Colore e forma: Added Added

Peso molecolare: 766.9582

Ref: 41-Y0000813

Bisoprolol fumarate

CAS: 104344-23-2

Bisoprolol fumarate

Formula: (C₁₈H₃₁NO₄)₂C₄H₄O₄

Purezza: 99.7%

Colore e forma: White

Peso molecolare: 766.46158

Ref: 47-1058

BISOPROLOL FUMARATE CRS

CAS: 104344-23-2

BISOPROLOL FUMARATE CRS

Formula: C₄₀H₆₆N₂O₁₂

Colore e forma: Added Added

Peso molecolare: 766.9582

Ref: 41-Y0000812

BISOPROLOL FOR PEAK IDENTIFICATION CRS

CAS: 104344-23-2

BISOPROLOL FOR PEAK IDENTIFICATION CRS

Colore e forma: Added Added

Ref: 41-Y0000877

Bisoprolol Fumarate

CAS: 104344-23-2

Aromatic drugs of amino-alcohols, other than those contg more than one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Formula: (C₁₈H₃₁NO₄)₂·C₄H₄O₄

Colore e forma: White Powder

Peso molecolare: 766.96

Ref: 45-1075757

Bisoprolol (hemifumarate)

CAS: 104344-23-2

Formula: C₄₀H₆₆N₂O₁₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 766.9582

Ref: IN-DA003271

Bisoprolol hemifumarate

CAS: 104344-23-2

Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart,

Formula: C₂₀H₃₃NO₆

Purezza: 98.69% - 99.84%

Colore e forma: White To Offf-White Powder

Peso molecolare: 383.49

Ref: TM-T0143

Bisoprolol hemifumarate salt

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄₀·5C₄H₄O₄

Purezza: 98.0 - 102.0 %

Colore e forma: White to almost white powder

Peso molecolare: 383.49

Ref: 7W-GP0667

Bisoprolol Hemifumarate

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄·5C₄H₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 325.45 0.5*116.07

Ref: 4Z-B-092

(±)-Bisoprolol-d7 Hemifumarate(iso-propyl-d7)

CAS: 104344-23-2

Purezza: 99 atom % D

Colore e forma: White Solid

Peso molecolare: 390.5

Ref: 3U-D7507

Bisoprolol fumarate

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 766.9582

Ref: 04-C10654000

Bisoprolol Fumarate

CAS: 104344-23-2

Colore e forma: Neat

Ref: 86-MM0460.08

Bisoprolol hemifumarate

Prodotto controllato

CAS: 104344-23-2

Bisoprolol hemifumarate is a selective beta-1 receptor blocker that has been used in the treatment of high blood pressure, heart failure, and other cardiovascular diseases. It is a prodrug that undergoes enzymatic hydrolysis to bisoprolol in the liver. Bisoprolol hemifumarate has been shown to be effective as an adjunctive therapy for patients with bowel disease and cardiac effects such as lowering blood pressure levels. This drug also has a positive effect on the heart by increasing the levels of natriuretic peptides and decreasing the level of atrial fibrillation (AF). Bisoprolol hemifumarate can be detected in human serum or plasma samples through an analytical method involving liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), which can then be analyzed by multivariate logistic regression to control for confounding factors such as age, gender, ethnicity, alcohol intake, and smoking status.

Formula: C₁₈H₃₁NO₄•(C₄H₄O₄)₀

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 383.48 g/mol

Ref: 3D-FB18827

Bisoprolol hemifumarate - Bio-X ™

Prodotto controllato

CAS: 104344-23-2

Bisoprolol is a β1- adrenergic antagonist agent that is used to treat hypertension and prevent myocardial infarction. As adrenergic neurotransmitters activate β1-receptors it causes an increase in blood pressure and heart rate. By reducing contractility and the need for oxygen through competitive inhibition of β1-adrenergic receptors, bisoprolol reduces the cardiac workload.

Formula: C₁₈H₃₁NO₄C₄H₄O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 383.48 g/mol

Ref: 3D-BB164256

Bisoprolol Hemifumarate

CAS: 104344-23-2

Applications A selective β-adrenergic blocker. Used as an antihypertensive.
References Tattersfield, A.E., et al.: Brit. J. Clin. Pharmacol., 18, 343 (1984), Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985), Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993),

Formula: C₁₈H₃₁NO₄·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 766.9582

Ref: TR-B510500

Bisoprolol for peak identification CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000877

Bisoprolol for system suitability CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000813