CAS 105454-04-4

7-Epitaxol

Descrizione:

7-Epitaxol, con il numero CAS 105454-04-4, è un derivato sintetico del composto naturale paclitaxel, noto per le sue proprietà anticancro. Questo composto è caratterizzato dalla sua complessa struttura policiclica, che include un nucleo di taxano essenziale per la sua attività biologica. 7-Epitaxol presenta un meccanismo d'azione simile a quello del paclitaxel, funzionando principalmente come stabilizzatore dei microtubuli, inibendo così la divisione cellulare e promuovendo l'apoptosi nelle cellule tumorali. La sua efficacia viene spesso valutata in vari tipi di cancro, inclusi il cancro al seno e quello ovarico. Il composto viene tipicamente somministrato in una formulazione che ne migliora la solubilità e la biodisponibilità, poiché è poco solubile in acqua. Inoltre, 7-Epitaxol potrebbe avere diverse proprietà farmacocinetiche rispetto al paclitaxel, portando potenzialmente a variazioni nei risultati terapeutici e negli effetti collaterali. La ricerca in corso mira a comprendere meglio il suo ampio spettro di attività biologiche e le potenziali applicazioni nella terapia del cancro.

Formula: C₄₇H₅₁NO₁₄

InChI: InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32+,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key: InChIKey=RCINICONZNJXQF-LYTKHFMESA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinonimi:

• (2alpha,5beta,7alpha,10beta,13alpha)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Epipaclitaxel
• 7-epi-Paclitaxel
• 7-epi-Taxol
• Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
• Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR- (2aalpha,4alpha,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4α,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Epitaxol
• 7-Epitaxol
• Paclitaxel EP impurity E
• 7-EpipaclitaxelQ: What is
• 7-EPIPACLITAXEL; 7-EPITAXOL; 7-EPI-PACLITAXEL; EPITAXOL
• 7-Epi Paclitaxel (Paclitaxel EP Impurity E)
• Paclitaxel Impurity 5（Paclitaxel EP Impurity E）
• Paclitaxel Impurity E (7-epi Paclitaxel)
• 7-Epipaclitaxel Q: What is the storage condition of
• 7-Epipaclitaxel, 98%, from Taxus chinensis (Pilg.) Rehder
• Propanedioicacid,2-(2-propyn-6-yl)-,diethylester
• Paclitaxel Impurity E
• Paclitaxel 7-Epi-Impurity
• 7-Epipaclitaxel(crude)
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid derivative
• 7-Epipaclitaxel Q: What is the CAS Number of
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4α,4aβ,6β
• Paclitaxel EP Impurity E (7-epi Paclitaxel)
• EPITAXOL, 7-
• 7-epi-Paclitaxel(7-Epitaxol)
• Paclitaxel Impurity Ⅲ:(7-Epi-Paclitaxel)
• Benzenepropanoicacid,beta-(benzoylaMino)-alpha-hydroxy-,6,12B-bis(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,11-dihydroxy-4A,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-ylester,(2ar-(
• 7-Epipaclitaxel, froM Taxus chinensis
• Paclitaxel Impurity E (7-Diverse Taxol)
• inhibit,Microtubule/Tubulin,7 epi Taxol,7epiTaxol,Inhibitor

7-epi-Taxol

CAS: 105454-04-4

7-epi-Taxol

Purezza: ≥98%

Peso molecolare: 853.91g/mol

Ref: 54-BUP06028

Paclitaxel EP Impurity E (7-epi Paclitaxel)

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Pale Pink Solid

Peso molecolare: 853.92

Ref: 4Z-P-2815

7-Epitaxol

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 853.92

Ref: 7W-GY8649

7-Epitaxol

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Purezza: 95%~99%

Peso molecolare: 853.918

Ref: BP-BP0098

7-epi-Paclitaxel

Prodotto controllato

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Neat

Peso molecolare: 853.91

Ref: 86-MM1489.08

7-epi-Taxol

CAS: 105454-04-4

Peso molecolare: 853.918

Ref: 10-F986733

7-epi-Taxol

CAS: 105454-04-4

1.

Formula: C₄₇H₅₁NO₁₄

Purezza: 99.32% - 99.93%

Colore e forma: Solid

Peso molecolare: 853.91

Ref: TM-T3S2372

7-Epi Paclitaxel

Prodotto controllato

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Colore e forma: Off-White

Peso molecolare: 853.91

Ref: TR-E588630

7-epi-Taxol

CAS: 105454-04-4

Paclitaxel is an anticancer drug that belongs to the class of taxanes. Paclitaxel binds to cell membranes and interferes with cell division by preventing the polymerization of microtubule proteins. This drug can be prepared by high-performance liquid chromatography (HPLC) and has minimal toxicity in humans, but is highly toxic in rats. Paclitaxel also inhibits glucose uptake in breast cancer cells, leading to significant cytotoxicity. It has inhibitory properties against toll-like receptor 4, which may contribute to its anti-inflammatory effects.

Formula: C₄₇H₅₁NO₁₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 853.91 g/mol

Ref: 3D-IM22711

Paclitaxel EP Impurity E

CAS: 105454-04-4

Formula: C₄₇H₅₁NO₁₄

Peso molecolare: 853.92

Ref: ST-EA-CP-P36005