CAS 105979-17-7

Benidipina

Descrizione:

Benidipina è un bloccante dei canali del calcio utilizzato principalmente nel trattamento dell'ipertensione e dell'angina pectoris. Appartiene alla classe degli antagonisti del calcio diidropiridinici, che funzionano inibendo l'ingresso di ioni calcio attraverso i canali del calcio di tipo L nel muscolo liscio vascolare e nel tessuto cardiaco, portando a vasodilatazione e riduzione del carico cardiaco. Benidipina presenta un meccanismo d'azione duale unico, poiché blocca sia i canali del calcio di tipo L che quelli di tipo T, migliorando la sua efficacia nella riduzione della pressione sanguigna. La sostanza è caratterizzata dalla sua lipofilia, che contribuisce alla sua capacità di penetrare efficacemente nelle membrane cellulari. Viene tipicamente somministrata per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. Gli effetti collaterali comuni possono includere vertigini, mal di testa e edema periferico, sebbene sia generalmente ben tollerata. Come per altri farmaci della sua classe, si consiglia cautela nei pazienti con determinate condizioni cardiovascolari o in quelli che assumono altri agenti antipertensivi. In generale, Benidipina rappresenta un'opzione preziosa nella gestione delle malattie cardiovascolari.

Formula: C₂₈H₃₂ClN₃O₆

InChI: InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1

InChI key: InChIKey=QZVNQOLPLYWLHQ-MKNUCDGGNA-N

SMILES: C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3[C@@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4

Sinonimi:

• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
• (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-
• BND
• Benidipine Hcl
• Capadipine
• Nacadipine
• (±)-Benidipine
• Benidipine
• (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester
• BENIDIPINE HYDROCHLORIDE
• (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester
• CONIEL
• (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

Benidipine

CAS: 105979-17-7

Formula: C₂₈H₃₁N₃O₆

Peso molecolare: 505.56

Ref: 7W-GP5445

Benidipine Hydrochloride

CAS: 105979-17-7, 91599-74-5

Formula: C₂₈H₃₁N₃O₆·HCl

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light yellow to Yellow to Orange powder to crystal

Peso molecolare: 542.03

Ref: 3B-B5629

Benidipine

CAS: 105979-17-7

Benidipine: potent oral calcium blocker, boosts nitric oxide synthase, enhances coronary flow, protects heart cells post-ischemia.

Formula: C₂₈H₃₁N₃O₆

Colore e forma: Solid

Peso molecolare: 505.56

Ref: TM-T63452

Benidipine

CAS: 105979-17-7

Benidipine is a calcium channel blocker that inhibits the flow of calcium ions into cardiac and smooth muscle cells, which decreases the rate of these cells' contractions. Benidipine also has been shown to have a protective effect on the heart by preventing injury from coronary artery disease and other cardiovascular diseases. In addition, benidipine is not broken down in the liver and has a low risk of drug interactions. Benidipine has been found to be effective in reducing blood pressure in patients with chronic renal failure, although it may cause tubulointerstitial injury. The effects of benidipine are thought to be due to its ability to inhibit the release of growth factor-β1 from human polymorphonuclear leukocytes (PMNLs) and inhibit the proliferation of HL-60 cells.

Purezza: Min. 95%

Ref: 3D-FB176235

Benidipine 5-(1-Benzylpiperidin-3-yl)-d10

Prodotto controllato

CAS: 105979-17-7

Formula: C₃₉D₁₀H₃₄N₄O₆

Colore e forma: Neat

Peso molecolare: 674.851

Ref: TR-B157507