CAS 106128-98-7

AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH

Descrizione:

La sostanza chimica con il nome "AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH" e numero CAS "106128-98-7" è un peptide sintetico composto da una sequenza di amminoacidi. Questo peptide presenta una varietà di gruppi funzionali caratteristici degli amminoacidi, inclusi gruppi amminici, acidi carbossilici e idrossilici, che contribuiscono alle sue proprietà biochimiche. La presenza di più catene laterali polari e cariche suggerisce che questo peptide possa mostrare caratteristiche idrofili, influenzando potenzialmente la sua solubilità in ambienti acquosi. La sequenza include amminoacidi essenziali come lisina e arginina, noti per il loro ruolo nelle interazioni proteiche e nella segnalazione cellulare. Inoltre, l'acetilazione all'estremità N-terminale (indicata da "AC") può migliorare la sua stabilità e biodisponibilità. Peptidi come questo sono spesso studiati per le loro potenziali applicazioni in farmacologia, biotecnologia e come strumenti di ricerca per comprendere le interazioni e le funzioni proteiche. In generale, le caratteristiche specifiche e il comportamento di questo peptide dipenderebbero dalla sua conformazione strutturale e dal contesto del suo utilizzo.

Formula: C₅₂H₈₈N₂₂O₁₇

Sinonimi:

• Myelin Basic Protein (1-11) (Guinea Pig, Horse, Porcine, Rabbit, Rat)
• Myelin Basic Protein (135-145), Human
• Ac-Mbp (Human, Porcine, Rat 1-11)
• Ac-Asqkrpsqrhg
• Acetyl-Golli-Mbp1 Hog7 (135-145) (Human)
• Acetyl-Myelin A1 Protein (135-145) (Human)
• Acetyl-Myelin Basic Protein (135-145) (Human)
• MBP (1-11), guinea pig, porcine, rabbit, rat, Myelin Basic Protein (135-145), human
• Acetyl-Golli-MBP1 HOG7 (135-145) (huMan), Acetyl-MBP (135-145) (huMan), Acetyl-Myelin A1 Protein (135-145) (huMan), Myelin Basic Protein (1-11) (guinea pig, horse, porcine, rabbit, rat)
• Glycine, N-acetyl-L-alanyl-L-seryl-L-glutaminyl-L-lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-histidyl-
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH
• MBP (1-11), GUINEA PIG, PORCINE, RABBIT, RAT
• Acetyl-Myelin Basic Protein (135-145)) (hu
• 235:PN:WO2010033207 SEQID:291 claimed protein
• ACETYL-MBP (135-145) (HUMAN)
• MBP (1-11) HUMAN

Acetyl-Myelin Basic Protein (Human, Porcine, Rat, 1-11)

CAS: 106128-98-7

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.
Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.
Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Formula: C₅₂H₈₈N₂₂O₁₇

Purezza: Min. 95%

Peso molecolare: 1,293.42 g/mol

Ref: 3D-PMB-3658-PI

MBP (1-11), human

CAS: 106128-98-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₅₂H₈₈N₂₂O₁₇

Peso molecolare: 1,293.42 g/mol

Ref: 3D-PP50289