CAS 1069-79-0

1,2-Distearoil-sn-glicero-3-fosfoetanolamina

Descrizione:

1,2-Distearoil-sn-glicero-3-fosfoetanolamina (DSPE) è un fosfolipide comunemente usato in biochimica e applicazioni farmaceutiche. Presenta due catene di acido stearico, che contribuiscono alle sue proprietà idrofobiche, e un gruppo testa di fosfoetanolamina che conferisce idrofobicità. Questa natura anfifilica consente al DSPE di formare doppie membrane lipidiche e micelle, rendendolo prezioso nei sistemi di somministrazione dei farmaci, in particolare per l'incapsulamento di farmaci idrofobici. Il DSPE è noto per la sua stabilità e capacità di formare liposomi, che sono vescicole sferiche in grado di incapsulare varie sostanze. Il composto è spesso utilizzato nella formulazione di farmaci e vaccini liposomali, migliorando la biodisponibilità e il targeting degli agenti terapeutici. Inoltre, il DSPE può essere modificato per includere catene di polietilene glicole (PEG), migliorando il tempo di circolazione e riducendo l'immunogenicità. La sua biocompatibilità e versatilità lo rendono un componente cruciale nello sviluppo di nanocarrier per la somministrazione mirata di farmaci e applicazioni di terapia genica.

Formula: C₄₁H₈₂NO₈P

InChI: InChI=1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1

InChI key: InChIKey=LVNGJLRDBYCPGB-LDLOPFEMSA-N

SMILES: [C@@H](OC(CCCCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O

Sinonimi:

• (2R)-3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(octadecanoyloxy)propyl octadecanoate
• (R)-Distearoylphosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphatidylethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
• 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
• 3-{[(2-Aminoethoxy)(Hydroxy)Phosphoryl]Oxy}-2-(Octadecanoyloxy)Propyl Octadecanoate
• 64: PN: WO2017201317 SEQID: 137 claimed RNA
• <span class="text-smallcaps">L</span>-α-Distearoylphosphatidylethanolamine
• <span class="text-smallcaps">L</span>-β,γ-Distearoyl-α-phosphatidylethanolamine
• Coatsome ME 8080
• Distearoyl-<span class="text-smallcaps">L</span>-α-phosphatidylethanolamine
• L-A-phosphatidylethanolamine,distearoyl
• Octadecanoic acid, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• Octadecanoic acid, 1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• Octadecanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, (R)-
• Stearin, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">L</span>-
• L-β,γ-Distearoyl-α-phosphatidylethanolamine

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Purezza: >97.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 748.08

Ref: 3B-D4214

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 748.0654

Ref: IN-DA007BD0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Purezza: ≥95%

Peso molecolare: 748.07g/mol

Ref: 54-BUP18008

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

CAS: 1069-79-0

(2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Distearate

Purezza: 95%

Peso molecolare: 748.07g/mol

Ref: 54-OR1007966

1,2-Distearoyl-sn-Glycero-3-Phosphatidylethanolamine

CAS: 1069-79-0

Formula: C41H82NO8P

Purezza: >98%

Colore e forma: Solid

Peso molecolare: 748.07

Ref: 48-37-1820

1,2-Distearoyl-SN-Glycero-3-Phosphoethanolamine

CAS: 1069-79-0

Formula: C₄₁H₈₂NO₈P

Peso molecolare: 748.08

Ref: 4Z-P-312003

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphatidylethanolamine (PE or GPEtn) capable of being used in the synthesis of liposomes.

Formula: C₄₁H₈₂NO₈P

Purezza: ≥95%

Colore e forma: Solid

Peso molecolare: 748.07

Ref: TM-T5249

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

CAS: 1069-79-0

Purezza: 98%

Peso molecolare: 748.08

Ref: 10-F986827

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

Prodotto controllato

CAS: 1069-79-0

Applications 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is used in the generation of micelles and liposomes.
References Høyrup, P., et al.: Biochim. Biophys. Acta, 1515, 133 (2001); Heberle, F., et al.: Cold Spring Harb Perspect Biol., 3, 1 (2011)

Formula: C₄₁H₈₂NO₈P

Colore e forma: Neat

Peso molecolare: 748.07

Ref: TR-D493610

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

CAS: 1069-79-0

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine is an effector protein that functions to stabilize the extracellular matrix. It has been shown to be effective in the stabilization of lipid bilayers. This compound is a biocompatible polymer that can be used as a model system for studying dispersive solid phase extraction (DSPE). The phase transition temperature of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine is approximately -10°C. This property makes it suitable for use in applications where freeze/thaw cycles are required. The nitrogen atoms in this compound can react with alkanoic acids and liposomes to form stable complexes. These interactions are important pharmacokinetic properties of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine because they allow for the delivery of drugs into cells through

Formula: C₄₁H₈₂NO₈P

Purezza: Min. 95%

Peso molecolare: 748.07 g/mol

Ref: 3D-FD178397