CAS 107724-20-9

(+)-Eplerenone

Descrizione:

(+)-Eplerenone è uno steroide sintetico e un antagonista selettivo dell'aldosterone, utilizzato principalmente nel trattamento dell'ipertensione e dell'insufficienza cardiaca. È caratterizzato dalla sua capacità di bloccare gli effetti dell'aldosterone, un ormone che regola i livelli di sodio e potassio nel corpo, promuovendo così la diuresi e riducendo la pressione sanguigna. Il composto ha una struttura molecolare unica che include un anello di lattone e una struttura spiro, contribuendo alla sua specificità e potenza. (+)-Eplerenone mostra una buona biodisponibilità orale ed è metabolizzato principalmente nel fegato, con una emivita che consente una somministrazione una volta al giorno. Il suo profilo farmacologico include un profilo di effetti collaterali favorevole rispetto ad altri diuretici, con una minore incidenza di iperkaliemia. Inoltre, è stato dimostrato che migliora i risultati nei pazienti con insufficienza cardiaca post-infarto miocardico. In generale, (+)-Eplerenone rappresenta un'importante opzione terapeutica nella medicina cardiovascolare, in particolare per i pazienti con condizioni legate all'eccesso di aldosterone.

Formula: C₂₄H₃₀O₆

InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key: InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N

SMILES: C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]

Sinonimi:

• Cgp 30083
• Epoxymexrenone
• Inspra
• Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
• Sc 6110
• Sc 66110
• Selara
• Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
• The Intermediates
• methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 414.50

Ref: 3B-E0905

EPLERENONE FOR PEAK IDENTIFICATION CRS

CAS: 107724-20-9

EPLERENONE FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₃₀O₆

Colore e forma: Powder

Peso molecolare: 414.4914

Ref: 41-Y0001706

EPLERENONE FOR SYSTEM SUITABILITY CRS

CAS: 107724-20-9

EPLERENONE FOR SYSTEM SUITABILITY CRS

Formula: C₂₄H₃₀O₆

Colore e forma: Powder

Peso molecolare: 414.4914

Ref: 41-Y0001705

EPLERENONE CRS

CAS: 107724-20-9

EPLERENONE CRS

Ref: 41-Y0001704

Eplerenone

CAS: 107724-20-9

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₀O₆

Colore e forma: White Off-White Crystalline Powder

Peso molecolare: 414.20424

Ref: 45-1237553

Eplerenone

CAS: 107724-20-9

Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension.

Formula: C₂₄H₃₀O₆

Purezza: 99.75% - ≥98%

Colore e forma: White Solid

Peso molecolare: 414.49

Ref: TM-T0083

Eplerenone

CAS: 107724-20-9

Eplerenone

Purezza: 99%

Peso molecolare: 414.49g/mol

Ref: 54-OR1027366

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 414.49

Ref: 7W-GP0150

Eplerenone-d3

CAS: 107724-20-9

Formula: C₂₄H₂₇D₃O₆

Colore e forma: White To Off-White Solid

Peso molecolare: 417.52

Ref: 4Z-E-132

Eplerenone

CAS: 107724-20-9

Eplerenone

Purezza: ≥98%

Peso molecolare: 414.49g/mol

Ref: 54-BUP11927

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Colore e forma: White To Off-White Solid

Peso molecolare: 414.50

Ref: 4Z-E-133

Eplerenone

Prodotto controllato

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Colore e forma: White

Peso molecolare: 414.49

Ref: 04-C13179750

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 414.498

Ref: 10-F093379

Eplerenone

Prodotto controllato

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Colore e forma: Neat

Peso molecolare: 414.49

Ref: 86-MM3530.00

Eplerenone-13C-d3

CAS: 107724-20-9

Formula: C₂₄H₂₇O₆D₃

Peso molecolare: 418.51

Ref: 4Z-E-134

PEG (n=25)

CAS: 107724-20-9

Formula: C₅₀H₁₀₂O₂₆

Peso molecolare: 1119.34

Ref: 4Z-E-134027

Eplerenone RS

CAS: 107724-20-9

Colore e forma: White Solid Crystalline Powder

Ref: 2K-1028100021

Eplerenone-d3

Prodotto controllato

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Formula: C₂₄H₂₇D₃O₆

Colore e forma: Neat

Peso molecolare: 417.51

Ref: TR-E588777

Eplerenone

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Formula: C₂₄H₃₀O₆

Colore e forma: Neat

Peso molecolare: 414.49

Ref: TR-E588775

Eplerenone - Bio-X ™

CAS: 107724-20-9

Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.

Formula: C₂₄H₃₀O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 414.49 g/mol

Ref: 3D-BE164415

Eplerenone

CAS: 107724-20-9

Aldosterone blocker

Formula: C₂₄H₃₀O₆

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 414.49 g/mol

Ref: 3D-FP22747