CAS 1092939-16-6

Ruxolitinib sulfate

CAS: 1092939-16-6

Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.

Formula: C₁₇H₂₀N₆O₄S

Colore e forma: Solid

Peso molecolare: 404.45

Ref: TM-T61988

Ruxolitinib sulfate

CAS: 1092939-16-6

Ruxolitinib is a small molecule that inhibits the activity of PD-1, which is a protein that regulates immune responses. Ruxolitinib has been shown to be effective against myelofibrosis and other diseases that are characterized by cellular dedifferentiation, such as chronic graft versus host disease. It also inhibits the production of proteins involved in tumor growth and progression. Ruxolitinib binds to PD-L1, an inhibitory receptor on T cells, and blocks the interaction between PD-L1 and its ligands, preventing T cell activation. The binding of ruxolitinib with PD-L1 can induce receptor internalization or activate downstream signalling pathways for apoptosis.

Formula: C₁₇H₂₀N₆O₄S

Purezza: Min. 95%

Peso molecolare: 404.4 g/mol

Ref: 3D-STB93916