CAS 1093861-60-9

Afoxolaner

Descrizione:

Afoxolaner è un insetticida e acaricida appartenente alla classe dei composti isoxazoline, utilizzato principalmente in medicina veterinaria per il trattamento e la prevenzione delle infestazioni da pulci e zecche in cani e gatti. Il suo meccanismo d'azione implica l'inibizione dei canali del cloruro attivati dall'acido gamma-aminobutirrico (GABA) e dal glutammato, portando alla paralisi e alla morte dei parassiti target. Afoxolaner è caratterizzato dalla sua alta efficacia contro un ampio spettro di ectoparassiti, comprese pulci, zecche e acari, ed è tipicamente somministrato per via orale sotto forma di compresse masticabili. Il composto è noto per i suoi effetti duraturi, fornendo protezione per diverse settimane dopo la somministrazione. Afoxolaner è generalmente ben tollerato negli animali domestici, con una bassa incidenza di effetti avversi. Il suo profilo di sicurezza, combinato con la sua efficacia, lo ha reso una scelta popolare tra i veterinari per la gestione delle infestazioni parassitarie. Come per qualsiasi farmaco, è importante seguire le linee guida per il dosaggio e consultare un veterinario per un uso appropriato.

Formula: C₂₆H₁₇ClF₉N₃O₃

InChI: InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)

InChI key: InChIKey=OXDDDHGGRFRLEE-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1(CC(=NO1)C=2C3=C(C(C(NCC(NCC(F)(F)F)=O)=O)=CC2)C=CC=C3)C4=CC(C(F)(F)F)=CC(Cl)=C4

Sinonimi:

• 4-[5-(3-chloro-5-trifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid [(2,2,2-trifluoroethylcarbamoyl)-methyl]-amide
• 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
• 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
• 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
• Afoxolaner
• Nexgard
• Avrana
• China biggest manufacturer,Afoxolaner,1093861-60-9
• 4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide
• afoxolaner-007

4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 625.8701

Ref: IN-DA0096RY

Afoxolaner

CAS: 1093861-60-9

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.

Formula: C₂₆H₁₇ClF₉N₃O₃

Purezza: 99.1% - 99.38%

Colore e forma: Solid

Peso molecolare: 625.87

Ref: TM-T13536

Afoxolaner

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 625.88

Ref: 4Z-A-263001

Afoxolaner

CAS: 1093861-60-9

Afoxolaner

Purezza: ≥98%

Peso molecolare: 625.87g/mol

Ref: 54-BUP13244

Afoxolaner-d6

CAS: 1093861-60-9

Formula: C₂₆H₁₁D₆ClF₉N₃O₃

Peso molecolare: 631.91

Ref: 4Z-A-263002

Afoxolaner

Prodotto controllato

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Colore e forma: Neat

Peso molecolare: 625.87

Ref: 04-C10047600

Afoxolaner (Standard)

CAS: 1093861-60-9

Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

Formula: C₂₆H₁₇ClF₉N₃O₃

Peso molecolare: 625.87

Ref: TM-TMSM-0384

Afoxolaner

CAS: 1093861-60-9

Colore e forma: Neat

Ref: 86-MM3935.00

Afoxolaner 100 µg/mL in Acetonitrile

Prodotto controllato

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Colore e forma: Single Solution

Peso molecolare: 625.87

Ref: 04-A10047600AL-100

Afoxolaner

CAS: 1093861-60-9

Afoxolaner is a bicyclic heterocycle that belongs to the class of insecticides. It is administered orally and has a high bioavailability in rats and dogs. Afoxolaner has been shown to have a pharmacokinetic profile similar to that of the reference drug, deltamethrin, with an effective dose range from 0.1-0.5 mg/kg in rats and dogs. The terminal half-life of afoxolaner is 7 days after oral administration. Afoxolaner is also effective against fleas, ticks, lice, mites, and mosquitoes in animal models and has been shown to be safe for use in cats and dogs at doses up to 1mg/kg (1mg/kg). There are no reports of allergic reactions or cutaneous lesions related to afoxolaner treatment.

Formula: C₂₆H₁₇ClF₉N₃O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 625.87 g/mol

Ref: 3D-FA104290

Afoxolaner

Prodotto controllato

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Colore e forma: Neat

Peso molecolare: 625.87

Ref: TR-A357710

Afoxolaner

CAS: 1093861-60-9

Formula: C₂₆H₁₇ClF₉N₃O₃

Peso molecolare: 625.88

Ref: ST-EA-CP-A291000