CAS 109581-93-3

Idrato di tacrolimus

Descrizione:

Idrato di tacrolimus, con il numero CAS 109581-93-3, è un agente immunosoppressore utilizzato principalmente nel trapianto di organi e nelle malattie autoimmuni. È derivato dal batterio Streptomyces tsukubaensis e funziona inibendo l'attivazione dei linfociti T, riducendo così la risposta immunitaria. La sostanza appare come una polvere bianca o bianco sporco ed è solubile in solventi organici come il metanolo e il dimetilsolfossido, ma ha una solubilità limitata in acqua. Idrato di tacrolimus è spesso formulato come un unguento topico o un farmaco orale, a seconda della sua applicazione. I suoi effetti farmacologici sono attribuiti alla sua capacità di legarsi a FKBP-12, una proteina che inibisce successivamente la calcineurina, un enzima critico nell'attivazione delle cellule T. Sebbene efficace, il tacrolimus può avere effetti collaterali, tra cui nefrotossicità e maggiore suscettibilità alle infezioni, richiedendo un attento monitoraggio durante il trattamento. In generale, Idrato di tacrolimus è un agente terapeutico vitale nella gestione di condizioni che richiedono soppressione immunitaria.

Formula: C₄₄H₆₉NO₁₂·H₂O

InChI: InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

InChI key: InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O

Sinonimi:

• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
• 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
• FK-506 Monohydrate
• Tacforius
• Tacrolimus hydrate
• Tacrolimushydrate
• Tsukubaenolide hydrate

TACROLIMUS FOR SYSTEM SUITABILITY CRS

CAS: 109581-93-3

TACROLIMUS FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001933

TACROLIMUS MONOHYDRATE CRS

CAS: 109581-93-3

TACROLIMUS MONOHYDRATE CRS

Formula: C₄₀H₃₃N₃O₄

Colore e forma: Added Modified

Peso molecolare: 619.7077

Ref: 41-Y0001926

Tacrolimus

CAS: 109581-93-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₄₄H₆₉NO₁₂·H₂O

Colore e forma: White Powder

Peso molecolare: 803.48198

Ref: 45-1642802

Tacrolimus monohydrate

CAS: 109581-93-3

Formula: C₄₄H₇₁NO₁₃

Purezza: 80%

Colore e forma: Solid

Peso molecolare: 822.0334

Ref: IN-DA0035MN

FK-506 monohydrate

CAS: 109581-93-3

Formula: C₄₄H₆₉NO₁₂·H₂O

Purezza: ≥ 98.0%

Colore e forma: White to off-white solid or powder

Peso molecolare: 822.03

Ref: 7W-GK6971

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate

Purezza: ≥95%

Peso molecolare: 822.05g/mol

Ref: 54-BUP14489

Tacrolimus Monohydrate

CAS: 109581-93-3

Tacrolimus Monohydrate

Purezza: 98%

Peso molecolare: 822.03g/mol

Ref: 54-OR1025734

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Formula: C₄₄H₆₉NO₁₂·H₂O

Purezza: >80.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 822.05

Ref: 3B-M2258

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.

Formula: C₄₄H₇₁NO₁₃

Purezza: 97.07% - 98.05%

Colore e forma: Solid

Peso molecolare: 822.05

Ref: TM-T20879

Tacrolimus RS

CAS: 109581-93-3

Colore e forma: White

Ref: 2K-1078400021

Tacrolimus Monohydrate

CAS: 109581-93-3

Formula: C₄₄H₆₉NO₁₂H₂O

Peso molecolare: 804.0 : 18.0

Ref: ST-EA-CP-T39005

Tacrolimus Hydrate

CAS: 109581-93-3

Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)

Formula: C₄₄H₆₉NO₁₂·H₂O

Colore e forma: Neat

Peso molecolare: 822.03

Ref: TR-T004130

Tacrolimus monohydrate

CAS: 109581-93-3

Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerative

Formula: C₄₄H₆₉NO₁₂·H₂O

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 822.03 g/mol

Ref: 3D-FT33601

Tacrolimus monohydrate - Bio-X ™

CAS: 109581-93-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Formula: C₄₄H₆₉NO₁₂·H₂O

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 822.03 g/mol

Ref: 3D-BT164433