CAS 1097263-60-9

Bosentan Related Compound C (1,2-bis({6-[4-(tert-butyl)phenylsulfonamido]-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl}oxy)ethane)

CAS: 1097263-60-9

Sulfonamides, nesoi

Formula: C₅₂H₅₂N₁₀O₁₀S₂

Colore e forma: Off-White Powder

Peso molecolare: 1040.33093

Ref: 45-1076148

Bosentan USP Related Compound C

CAS: 1097263-60-9

Formula: C₅₂H₅₂N₁₀O₁₀S₂

Colore e forma: Pale Yellow Solid

Peso molecolare: 1041.17

Ref: 4Z-B-1210

N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide

Prodotto controllato

CAS: 1097263-60-9

Impurity Bosentan USP Related Compound C
Applications N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide is an impurity of Bosentan (B675900), a mixed endothelin receptor antagonist. Bosentan USP Related Compound C.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Formula: C₅₂H₅₂N₁₀O₁₀S₂

Colore e forma: Neat

Peso molecolare: 1041.16

Ref: TR-E676300

N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide-d4

Prodotto controllato

CAS: 1097263-60-9

Applications N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide-d4 is labelled N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide (E676300) which is an impurity of Bosentan (B675900), a mixed endothelin receptor antagonist.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Formula: C₅₂D₄H₄₈N₁₀O₁₀S₂

Colore e forma: Neat

Peso molecolare: 1045.185

Ref: TR-E676302

Bosentan impurity C

CAS: 1097263-60-9

Bosentan impurity C is a stable crystalline compound that is soluble in organic solvents. It has been identified as an impurity of the drug bosentan, and has been found to be present in the drug at concentrations of up to 0.2%. Bosentan impurity C can be prepared by crystallization from an alkaline solution and can also be obtained as a salt form. The salt form is a dimer that consists of two bosentan molecules linked together by one oxygen atom. Bosentan impurity C is stable under normal conditions and does not undergo any changes when exposed to light or heat. This compound has shown no significant adverse effects on humans who have taken it, with no adverse effects on the kidney, liver, or lungs reported.

Formula: C₅₂H₅₂N₁₀O₁₀S₂

Purezza: Min. 95%

Peso molecolare: 1,041.16 g/mol

Ref: 3D-IB64076

Bosentan USP Related Compound C

CAS: 1097263-60-9

Formula: C₅₂H₅₂N₁₀O₁₀S₂

Peso molecolare: 1041.17

Ref: ST-EA-CP-B59004