CAS 109889-09-0

Granisetron

Descrizione:

Granisetron è un antagonista selettivo del recettore della serotonina 5-HT3 utilizzato principalmente come antiemetico per prevenire nausea e vomito associati a chemioterapia, radioterapia e chirurgia. È una polvere cristallina bianca o bianco sporco solubile in acqua e presenta un valore di pKa indicativo della sua natura debolmente basica. Granisetron ha una formula molecolare che riflette la sua struttura complessa, che include un anello di piperidina e un gruppo carbonilico, contribuendo alla sua attività farmacologica. La sostanza viene tipicamente somministrata per via orale o endovenosa, e la sua farmacocinetica dimostra una emivita relativamente lunga, consentendo una gestione efficace dell'emesi. Granisetron è ben tollerato, con un profilo di effetti collaterali che può includere mal di testa, stitichezza e vertigini. La sua efficacia nel bloccare i recettori della serotonina nel sistema nervoso centrale lo rende un prezioso agente terapeutico in oncologia e nella cura post-operatoria. Come con tutti i farmaci, è essenziale considerare le potenziali interazioni farmacologiche e controindicazioni quando si prescrive Granisetron.

Formula: C₁₈H₂₄N₄O

InChI: InChI=1/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-

InChI key: InChIKey=MFWNKCLOYSRHCJ-BTTYYORXNA-N

SMILES: C(N[C@H]1C[C@@]2(N(C)[C@](C1)(CCC2)[H])[H])(=O)C=3C=4C(N(C)N3)=CC=CC4

Sinonimi:

• 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
• 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo-
• 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-
• 9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.
• Apf 530
• Brl 43694
• Brl 43964
• Granisetron free base
• Kevatril
• Sancuso
• Sustol
• endo-Granisetron

Granisetron

CAS: 109889-09-0

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₁₈H₂₄N₄O

Colore e forma: Off-White Light Yellow Powder

Peso molecolare: 312.19501

Ref: 45-1298092

1-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide

CAS: 109889-09-0

Formula: C₁₈H₂₄N₄O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 312.4094

Ref: IN-DA007EID

Granisetron

CAS: 109889-09-0

Formula: C₁₈H₂₄N₄O

Peso molecolare: 312.42

Ref: 4Z-G-0725

Granisetron Hydrochloride

CAS: 107007-99-8, 109889-09-0

Formula: C₁₈H₂₄N₄O·HCl

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 348.88

Ref: 3B-G0401

Granisetron

CAS: 109889-09-0

Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.

Formula: C₁₈H₂₄N₄O

Colore e forma: Solid

Peso molecolare: 312.41

Ref: TM-T22340

1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide

Prodotto controllato

CAS: 109889-09-0

1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide is a chemical inhibitor of the 5HT2 receptor, which is responsible for regulating nausea and vomiting. It has been shown to have antiemetic properties, and can be used in chemotherapy to control nausea and vomiting. The 5HT2 receptor is coupled to Gs proteins and inhibits adenylyl cyclase activity, while 1MMAI binds to the 5HT2A receptor and blocks serotonin from binding. This prevents serotonin from activating Gq protein receptors, which are involved in the generation of intracellular calcium concentrations that lead to neurotransmitter release. 1MMAI also inhibits the activation of phospholipase C by serotonin, resulting in decreased levels of diacylglycerol (DAG) and inositol triphosphate (IP3). These changes inhibit plate

Formula: C₁₈H₂₄N₄O

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 312.41 g/mol

Ref: 3D-FM137557

Granisetron

Prodotto controllato

CAS: 109889-09-0

Applications Granisetron is a selective 5HT-3 antagonist.

Formula: C₁₈H₂₄N₄O

Colore e forma: Neat

Peso molecolare: 312.41

Ref: TR-G780013