CAS 11006-33-0

fleomicina da Streptomyces verticillus

Descrizione:

La pleomicina è un antibiotico antitumorale derivato dal batterio Streptomyces verticillus. È caratterizzata dalla sua capacità di indurre rotture nei filamenti di DNA, il che contribuisce alla sua efficacia nel trattamento del cancro. La pleomicina è un glicopeptide, costituito da una struttura complessa che include uno scheletro peptidico e una parte zuccherina, che ne migliora la solubilità e l'attività biologica. Il composto mostra un ampio spettro di attività contro vari tipi di tumori, in particolare tumori delle cellule germinali e linfomi. Il suo meccanismo d'azione implica il legame al DNA e la generazione di radicali liberi, portando a danni ossidativi. La pleomicina viene tipicamente somministrata per iniezione ed è nota per i suoi potenziali effetti collaterali, tra cui tossicità polmonare e reazioni cutanee. Grazie alle sue proprietà uniche, è spesso utilizzata in combinazione con altri agenti chemioterapici per migliorare i risultati terapeutici. Il numero CAS 11006-33-0 identifica in modo univoco la pleomicina nelle banche dati chimiche, facilitando la ricerca e le applicazioni cliniche.

Formula: C₅₅H₈₆N₂₀O₂₁S₂

InChI: InChI=1/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

Sinonimi:

• 2'-{5-acetyl-15-(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)-13-[{[(2R,3S,4S,5S,6S)-3-{[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-4',5'-dihydro-2,4'-bi-1,3-thiazole-4-carboxamide (non-preferred name)
• Phleomycin
• Phleomycin Streptomyces verticillus
• phleomycin from streptomyces*verticillus
• PHLEOMYCIN USP/EP/BP
• phleomycincomplex
• ZEOCIN(TM)
• CL990-cin
• PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
• nsc616586
• hleoMycin froM streptoMyces verticillus

Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered

CAS: 11006-33-0

Phleomycin, 20mg/mL in 5mM HEPES buffer, sterile-filtered

Ref: 02-J67027

Phleomycin

CAS: 11006-33-0

Formula: C₅₅H₈₅ClCuN₂₀O₂₁S₂

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 1525.5138

Ref: IN-DA00HBO1

Phleomycin

CAS: 11006-33-0

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.

Formula: C₄₈H₆₉N₁₇O₂₀S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1268.29

Ref: TM-T21498

Phleomycin, 1 pack = 1 vial

CAS: 11006-33-0

Phleomycin, 1 pack = 1 vial

Ref: 54-BI3852A

Phleomycin

CAS: 11006-33-0

Formula: C₅₅H₈₅O₂₁N₂₀S₂Cu·HCl

Purezza: ≥ 90% (HPLC)

Colore e forma: Blue, hygroscopic powder

Peso molecolare: 1525

Ref: 7W-GA6020

Phleomycin

CAS: 11006-33-0

Phleomycin

Colore e forma: Powder

Peso molecolare: 1,425.51g/mol

Ref: 54-BI3852

Phleomycin (PLM) ex. Streptomyces verticillus for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 11006-33-0

Formula: C₅₁H₇₅N₁₇O₂₁S₂

Purezza: 80-120%

Colore e forma: Blue, Powder

Peso molecolare: 1326.37

Ref: SR-62374

Phleomycin HCl

CAS: 11006-33-0

Phleomycin HCl is an antibiotic compound derived from *Streptomyces verticillus*, which is known for its robust DNA-cleaving activity. As an antibiotic, it functions primarily by inducing breaks in DNA strands, thereby inhibiting DNA replication and transcription processes. This mechanism of action is particularly effective in targeting rapidly dividing cells, making Phleomycin a valuable tool in molecular biology.

Formula: C₅₅H₈₅O₂₁N₂₀S₂Cu•HCl

Colore e forma: Blue Powder

Peso molecolare: 1,525 g/mol

Ref: 3D-AP156948

Phleomycin

CAS: 11006-33-0

Phleomycin is an antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing breaks by generating free radicals in the presence of oxygen and ferrous ions, leading to cell death. Phleomycin is prominently used in molecular biology applications as a selective agent in the generation of stable transfectants. It is particularly effective in selecting for cells that have integrated vectors conferring resistance, such as the Sh ble gene used in yeast, plant, and mammalian cell systems. Due to its potent DNA-cleaving ability, Phleomycin is valuable in studies requiring stringent selection pressure. Researchers commonly utilize it in experiments focusing on genetic modification and cellular resistance development.

Formula: C₅₁H₇₅N₁₇O₂₁S₂

Purezza: Min. 95%

Peso molecolare: 1,326.38 g/mol

Ref: 3D-AP106412