CAS 11024-24-1

Digitonina

Descrizione:

Digitonina è un glicoside derivato dalla pianta Digitalis purpurea, comunemente nota come digitale. Viene utilizzato principalmente in biochimica e farmacologia per la sua capacità di solubilizzare selettivamente le proteine di membrana, rendendolo prezioso nello studio delle membrane cellulari e dei loro componenti. Digitonina ha una struttura complessa, caratterizzata da uno scheletro steroideo legato a una porzione di zucchero, che contribuisce alla sua natura anfipatica. Questa proprietà gli consente di interagire con le doppie membrane lipidiche, facilitando l'estrazione delle proteine di membrana mantenendo la loro integrità funzionale. Oltre alle sue applicazioni biochimiche, Digitonina mostra effetti citotossici su alcuni tipi di cellule, il che ha implicazioni per il suo utilizzo nella ricerca e in contesti terapeutici potenziali. È importante maneggiare Digitonina con cura, poiché può essere tossico a concentrazioni più elevate. In generale, Digitonina funge da strumento cruciale nello studio della biologia delle membrane e nell'isolamento delle proteine associate alle membrane.

Formula: C₅₆H₉₂O₂₉

InChI: InChI=1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36-,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1

InChI key: InChIKey=UVYVLBIGDKGWPX-KUAJCENISA-N

SMILES: C[C@@]12[C@@]3([C@]([C@@H](O)[C@]1([C@]4([C@](CC2)([C@]5(C)[C@@](CC4)(C[C@@H](O[C@@H]6O[C@H](CO)[C@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@@H](CO)O8)[C@@H](O[C@H]%10[C@H](O)[C@@H](O)[C@H](O)CO%10)[C@H](O)[C@@H](CO)O7)[C@H](O)[C@H]6O)[C@H](O)C5)[H])[H])[H])[H])(O[C@@]%11([C@H]3C)CC[C@@H](C)CO%11)[H])[H]

Sinonimi:

• (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-(4xi)-beta-D-xylo-hexopyranosyl-(1->4)-beta-D-galactopyranoside
• (2alpha,3beta,5alpha,15beta,25R)-spirostan-2,3,15-triol
• (2α,3β,5α,15β,25R)-2,15-Dihydroxyspirostan-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-β-<smallcap>D</span>-galactopyranoside
• Ai3-44893
• Brn 0078654
• Digitin
• Digitogenin, 3-[O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-β-<smallcap>D</span>-galactopyranoside]
• Digitogenin, 3-[O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside]
• Digitogenin, glycoside
• Digitonina
• Digitonine
• Nsc 23471
• Nsc 237417
• Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Spirostan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-2)-O-(beta-D-xylopyranosyl-(1-3))-O-beta-D-glucopyranosyl-(1-4)-
• beta-D-Galactopyranoside, (2alpha,3beta,5alpha,15beta,25R)-2,15-dihydroxyspirostan-3-yl O-beta-D-glucopyranosyl-(1.fwdarw.3)-O-beta-D-galactopyranosyl-(1.fwdarw.2)-O-(beta-D-xylopyranosyl-(1.fwdarw.3))-O-beta-D-glucopyranosyl-(1.fwdarw.4)-
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-xylopyranosyl-(1→3)]-O-β-<smallcap>D</span>-glucopyranosyl-(1→4)-
• β-D-Galactopyranoside, (2α,3β,5α,15β,25R)-2,15-dihydroxyspirostan-3-yl O-β-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-
• Digitonin
• Spirostan, β-D-galactopyranoside deriv.

Digitonin

CAS: 11024-24-1

Formula: C₅₆H₉₂O₂₉

Colore e forma: White to Light yellow powder to crystaline

Peso molecolare: 1,229.32

Ref: 3B-D0540

Digitonin

CAS: 11024-24-1

Digitonin

Formula: C₅₆H₉₂O₂₉

Colore e forma: white to yellowish powder

Peso molecolare: 1,229.31g/mol

Ref: 54-BID3301

Digitonin

CAS: 11024-24-1

Formula: C₅₆H₉₂O₂₉

Colore e forma: White to pale yellow crystalline powder

Peso molecolare: 1229.31

Ref: 7W-GC7189

Digitonin

CAS: 11024-24-1

Formula: C₅₆H₉₂O₂₉

Purezza: 95%~99%

Peso molecolare: 1229.32

Ref: BP-BP0488

Digitonin

CAS: 11024-24-1

Digitonin is a natural product of the glycoside family and is a detergent.

Formula: C₅₆H₉₂O₂₉

Colore e forma: Physical Description Crystals Or White Powder (Ntp 1992)

Peso molecolare: 1229.31

Ref: TM-T2721

Digitonin Glycosides

Prodotto controllato

CAS: 11024-24-1

Formula: C₅₆H₉₂O₂₉

Colore e forma: White Solid

Peso molecolare: 1229.31

Ref: TR-D446305

Digitonin - water-insoluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated β-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol This Digitonin product is insoluble in water.

Formula: C₅₆H₉₂O₂₉

Colore e forma: Powder

Peso molecolare: 1,229.34 g/mol

Ref: 3D-OD09275

Digitonin, water-insoluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated &beta;-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol.

Formula: C₅₆H₉₂O₂₉

Peso molecolare: 1,229.34 g/mol

Ref: 3D-D-3100

Digitonin, stable clear, water-soluble

CAS: 11024-24-1

This Digitonin product (stable clear, water soluble) is a superior water soluble Digitonin with improved stability for aqueous solutions. Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Digitonin has hemolytic activity and is toxic to humans. Digitonin is frequently used for the solubilization of membrane proteins and for the permeabilization of cellular and nuclear membranes. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated β-hydroxysterols. This mechanism is used in procedures for the determination of cholesterol and ergosterol using Digitonin.
About this product: Aqueous solutions of conventional Digitonin will precipitate upon cooling to 4°C and will lose most of the biochemical function. Therefore, the precipitate is usually removed by filtration in many protocols. This filtration however decreases the concentration of Digitonin and alters the solubilizing power of the original product. In addition, precipitation and subsequent filtration result in an unknown Digitonin concentration in the final solutions and may negatively affect the reproducibility of any experiment with such solutions. In contrast to conventional Digitonin, our product Digitonin, stable clear, water soluble is a special grade that will not precipitate for at least one week.

Formula: C₅₆H₉₂O₂₉

Peso molecolare: 1,229.34 g/mol

Ref: 3D-D-3203

Digitonin, water-soluble

CAS: 11024-24-1

Digitonin is produced from seeds of Digitalis pupurea and other Digitalis species. It is a steroid glycoside consisting of the aglycone digitogenin linked to five sugar residues. Reaction of naturally occurring steroids carrying a 3b-hydroxyl group with digitonin results in an insoluble precipitate. Digitonin has hemolytic activity and is toxic to humans. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated beta-hydroxysterols. Digitonin is frequently used for solubilization of membrane proteins and permeabilization of cellular and nuclear membranes. Due to the complexing interactions it can be used for the determination of cholesterol and ergosterol.

Formula: C₅₆H₉₂O₂₉

Peso molecolare: 1,229.34 g/mol

Ref: 3D-D-3200

Digitonin (Digitin) extrapure, 50%

CAS: 11024-24-1

Formula: C₅₆H₉₂O₂₉

Colore e forma: White, Crystalline powder, Clear, Colourless

Peso molecolare: 1229.30

Ref: SR-53755