CAS 110417-88-4

dolastatina 10

Descrizione:

dolastatina 10 è un potente peptide derivato dal mollusco marino Dolabella auricularia, noto per le sue significative proprietà antitumorali. È caratterizzato da una struttura complessa che include un telaio ciclico e una sequenza unica di amminoacidi, che contribuisce alla sua attività biologica. dolastatina 10 mostra forti effetti citotossici contro diverse linee cellulari tumorali, rendendolo un argomento di interesse nella ricerca sul cancro e nello sviluppo di farmaci. Il suo meccanismo d'azione coinvolge principalmente l'interruzione della dinamica dei microtubuli, portando all'arresto del ciclo cellulare e all'apoptosi nelle cellule maligne. Il composto è anche noto per la sua bassa tossicità nelle cellule normali, il che ne aumenta il potenziale terapeutico. Tuttavia, la sua applicazione clinica è stata limitata a causa di sfide nella sintesi e stabilità. Gli studi in corso mirano a esplorare i suoi derivati e analoghi per migliorare l'efficacia e ridurre gli effetti collaterali. In generale, dolastatina 10 rappresenta un composto promettente nella ricerca di nuovi agenti anticancro.

Formula: C₄₂H₆₈N₆O₆S

InChI: InChI=1/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32?,33?,35-,36-,37-,38+/m1/s1

InChI key: InChIKey=OFDNQWIFNXBECV-VFSYNPLYSA-N

SMILES: [C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C2=NC=CS2)=O)C)(OC)[C@]3(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)N(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC3)[H]

Sinonimi:

• <span class="text-smallcaps">L</smallcap>-Valinamide, N,N-dimethyl-<smallcap>L</span>-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
• <span class="text-smallcaps">L</smallcap>-Valinamide, N,N-dimethyl-<smallcap>L</span>-valyl-N-[2-methoxy-4-[2-[1-methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-
• Ccris 7310
• Dls 10
• Dolostatin
• L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-
• N,N-Dimethyl-<span class="text-smallcaps">L</smallcap>-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-<smallcap>L</span>-valinamide
• N,N-dimethyl-D-valyl-N-[(4R,5R)-3-methoxy-1-{2-[(1S,2S)-1-methoxy-2-methyl-3-oxo-3-{[(1R)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-D-valinamide
• N,N-dimethylvalyl-N-{3-methoxy-1-[2-(1-methoxy-2-methyl-3-oxo-3-{[2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl)pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl}-N-methylvalinamide
• Nsc 376128
• N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
• Dolastatin-10
• L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
• Dolastatin 10
• Dolastain10
• Dolastatin 10,DLS 10,NSC 376128, >99%
• From dolabella auricularia (sea hare)
• CS-1367
• Nsc376128
• B720389K560
• 6-[bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]
• Dolastatin 10 (NSC-376128)
• (2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
• amino]-6-oxohexanoic acid

Dolastatin 10

CAS: 110417-88-4

Formula: C₄₂H₆₈N₆O₆S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 785.0909

Ref: IN-DA003PVY

Dolastatin 10

CAS: 110417-88-4

Dolastatin 10

Purezza: ≥98%

Peso molecolare: 785.09g/mol

Ref: 54-BUP00284

Dolastatin 10

CAS: 110417-88-4

Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Formula: C₄₂H₆₈N₆O₆S

Purezza: 99.00%

Colore e forma: Solid

Peso molecolare: 785.09

Ref: TM-TP1180

Dolastatin 10

CAS: 110417-88-4

Purezza: ≥98%

Peso molecolare: 785.0999756

Ref: 10-F862797