CAS 11056-06-7

Bleomicina

Descrizione:

Bleomicina è un antibiotico glicopeptidico che viene utilizzato principalmente nella chemioterapia per il cancro. È derivato dal batterio Streptomyces verticillus ed è noto per la sua capacità di indurre rotture nei filamenti di DNA, il che porta all'inibizione della crescita delle cellule tumorali. Il composto presenta un meccanismo d'azione unico legandosi al DNA e generando radicali liberi in presenza di ossigeno, causando danni ossidativi. Bleomicina è particolarmente efficace contro alcuni tipi di tumori, tra cui il cancro testicolare e il linfoma di Hodgkin. Viene somministrato per iniezione e può causare effetti collaterali come tossicità polmonare, reazioni cutanee e febbre. La sostanza è caratterizzata dal suo peso molecolare relativamente basso e da una struttura complessa che include un sito di legame per metalli, cruciale per la sua attività. A causa della sua azione specifica sulle cellule in rapida divisione, Bleomicina è spesso utilizzato in combinazione con altri agenti chemioterapici per migliorare l'efficacia del trattamento riducendo al minimo la resistenza. Il suo utilizzo richiede un attento monitoraggio a causa dei potenziali effetti avversi, in particolare sulla funzione polmonare.

Formula: Unspecified

InChI: InChI=1/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1

Sinonimi:

• Blenamax
• Bleo
• Bleo-Kyowa
• Bleocin
• Bleomycins
• Nsc 125066
• [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[[4-[[1-[2-[4-[4-(4-guanidinobutylcarbamoyl)thiazol-2-yl]thiazol-2-yl]ethylcarbamoyl]-2-hydroxy-propyl]amino]-2-hydroxy-1,3-dimethyl-4-oxo-butyl]amino]-1-(3H-imidazol-4-yl)-3-oxo-propoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl] carbamate
• (3-{[(2'-{(5S,8S,9S,10R,13S)-15-{6-amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methylpyrimidin-4-yl}-13-[(R)-{[3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-5-[(1R)-1-hydroxyethyl]-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-2,4'-bi-1,3-thiazol-4-yl)carbonyl]amino}propyl)(dimethyl)sulfonium (non-preferred name)
• N1-(3-(dimethylsulfonio)propyl)bleomycinamide) (Bleomycin A2)
• BLM
• Blenoxane
• (2R,3S,4S,5R,6R)-2-({(3S,4S,5S,6S)-2-[2-{[(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)carbonyl]amino}-3-[(4-{[1-({2-[4-({4-[(diaminomethylidene)amino]butyl}carbamoyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}carbamoyl)-2-hydroxypropyl]amino}-2-hydroxy-1,3-dimethyl-4-oxobutyl)amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-6-ethyl-4,5-dimethyltetrahydro-2H-pyran-3-yl}oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate
• 3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxo-propyl)amino]-3-oxo-propyl]-5-methyl-pyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino]-3-hydroxy-2-methyl-pentanoyl]amino]-3-hydroxy-butanoyl]amino]ethyl]thiazol-4-yl]thiazole-4-carbonyl]amino]propyl-dimethyl-sulfonium
• Bleomycin

Bleomycin Sulfate (mixture)

CAS: 11056-06-7, 9041-93-4

Purezza: >85.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Ref: 3B-B3972

Bleomycin

CAS: 11056-06-7

Bleomycin is an antineoplastic antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing strand breaks through the generation of free radicals, particularly in regions rich in guanine and cytosine. This leads to inhibition of DNA synthesis and, consequently, cellular replication, making it effective in targeting rapidly dividing cancer cells.

Formula: C₅₅H₈₄N₁₇O₂₁S₃

Purezza: Min. 95%

Peso molecolare: 1,415.56 g/mol

Ref: 3D-AB30158

Bleomycin Free Base

CAS: 11056-06-7

Bleomycin Free Base, a glycopeptide antibiotic, halts DNA function and treats solid tumors.

Formula: C₅₅H₈₄N₁₇O₂₁S₃

Colore e forma: Solid

Peso molecolare: 1415.55

Ref: TM-T71445