CAS 110880-55-2

(SAR9,MET(O2)11)-SOSTANZA P

Descrizione:

(SAR9,MET(O2)11)-SOSTANZA P, con il numero CAS 110880-55-2, è un analogo sintetico del neuropeptide Sostanza P, coinvolto in vari processi fisiologici, tra cui la percezione del dolore, l'infiammazione e le risposte allo stress. Questo composto è caratterizzato da modifiche specifiche nella sua sequenza di amminoacidi, in particolare la sostituzione del nono amminoacido con sarcosina (SAR9) e l'incorporazione di un ossido di metionina (MET(O2)) nella undicesima posizione. Queste modifiche migliorano la sua stabilità e bioattività rispetto al peptide naturale. Il composto mostra alta affinità per i recettori della neurochinina, in particolare i recettori NK1, che sono implicati nelle vie di segnalazione del dolore. La sua struttura unica consente potenziali applicazioni terapeutiche nella gestione del dolore e nell'infiammazione neurogenica. Inoltre, la presenza del gruppo ossido di metionina può influenzare le sue proprietà farmacocinetiche, come solubilità e stabilità metabolica. In generale, (SAR9,MET(O2)11)-SOSTANZA P rappresenta un significativo progresso nello sviluppo di terapie basate su peptidi mirate alle vie della neurochinina.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

InChI: InChI=1/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCS(=O)(=O)C)C(=N)O)O)N=C(CN(C)C(=O)[C@H](Cc1ccccc1)N=C([C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@H](CCC(=N)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O)O)O)O)O

Sinonimi:

• Rpkpqqffsarlm(O2)
• H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-Nh2
• Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-Nh2
• [Sar9 ,Met(O2 )11 ]-Substance P Highly Specific Neurokinin Nk1 Receptor 97+%
• [Sar9,met(o2)11]-substancephighlyspecificneurokininnk1receptor
• substance P, Sar(9)-Met(O2)(11)-
• N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-N-methylglycyl-N-[(2S)-1-amino-4-(methylsulfonyl)-1-oxobutan-2-yl]-L-leucinamide
• Bhsar-sp
• [Sar9,Met(O2)11]SP
• Substance P, 9-(N-methylglycine)-, S,S-dioxide
• 9-Sarcosyl-11-methionine(o2)-substance p
• [Sar9]substance P sulphone
• Sarcosyl(9)-substance p sulfone
• [Sar9]SP sulphone
• 9-Sar-substance p sulfone
• [SAR9,MET(O2)11]-SUBSTANCE P?, >98%
• [Sar9, Met(O2)11
• [Sar9,Met(O2)11]-Substance P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2?, >98%
• [Sar9]SP sulfone
• (SAR9,MET(O2)11)-SUBSTANCE P USP/EP/BP
• Bolton-hunter reagent-substance p. sar(9)-Met(02)(11)
• (SAR9,MET(O2)11)-SUBSTANCE P
• L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Sar-L-Leu-4-(Methylsulfonyl)-L-Abu-NH2
• (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfonyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
• Bolton hunter-9-sar-11-Met(02)-substance p

(Sar⁹,Met(O₂)¹¹)-Substance P

CAS: 110880-55-2

This NK-1 receptor agonist exhibits the highest selectivity for NK-1 receptors in various bioassays. It evokes a concentration-dependent increase in mucus secretion and is much more potent than substance P (EC₅₀= 1.7 · 10-⁶M).

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purezza: 96.3%

Colore e forma: White Lyophilisate

Peso molecolare: 1393.68

Ref: 01-4013867

[Sar9,Met(O2)11]-Substance P

CAS: 110880-55-2

[Sar9,Met(O2)11]-Substance P

Purezza: ≥98%

Peso molecolare: 1393.66g/mol

Ref: 54-BUP01353

[Sar9, Met(O2)11]-Substance P

CAS: 110880-55-2

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Peso molecolare: 1393.66

Ref: 7W-GK9596

[Sar9,Met(O2)11]-Substance P

CAS: 110880-55-2

[Sar9,Met(O2)11]-Substance P (NA) is an agonist of NK1 receptor.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purezza: >99.99%

Colore e forma: Solid

Peso molecolare: 1393.66

Ref: TM-T7828

(Sar 9,Met(O2)11)-Substance P

CAS: 110880-55-2

Substance P is a neuropeptide that is found in the brain and throughout the peripheral nervous system. It has been found to be involved in numerous physiological processes, including pain transmission, vasodilation, and inflammation. Substance P binds to neurokinin-1 receptor (NK-1R) with high affinity. NK-1R has been shown to be localized on cells of the submandibular gland and salivary gland. Techniques such as binding experiments have shown that substance P binds to NK-1R with high affinity and is therefore likely involved in salivation and other functions of these glands.

Formula: C₆₄H₁₀₀N₁₈O₁₅S

Purezza: Min. 95%

Peso molecolare: 1,393.66 g/mol

Ref: 3D-FS110428