CAS 112849-17-9

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butil)dimetilsilil]ossi]-2-metilenocicloesilidene]etilidene]ottaidro-7a-metil-1H-inden-1-il]-1-ciclopropil-2-penten-1-one

Descrizione:

La sostanza chimica con il nome "(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butil)dimetilsilil]ossi]-2-metilenocicloesilidene]etilidene]ottaidro-7a-metil-1H-inden-1-il]-1-ciclopropil-2-penten-1-one" e numero CAS "112849-17-9" è un composto organico complesso caratterizzato da molteplici stereocentri e una varietà di gruppi funzionali. Presenta un gruppo ciclopropilico e una porzione di pentenone, indicando una reattività potenziale tipica dei composti carbonilici insaturi. La presenza di gruppi tert-butil dimetilsililici suggerisce che il composto possa mostrare proprietà idrofobiche significative e stabilità contro l'idrolisi, rendendolo utile in varie applicazioni sintetiche. L'intricata estereoquimica implica che possa avere un'attività biologica o selettività specifica, che è spesso un obiettivo nella chimica medicinale. In generale, la complessità strutturale e la diversità funzionale di questo composto lo posizionano come un'entità potenzialmente preziosa nella sintesi organica e nello sviluppo farmaceutico.

Formula: C₃₉H₆₆O₃Si₂

InChI: InChI=1/C39H66O3Si2/c1-27(16-23-35(40)30-18-19-30)33-21-22-34-29(15-14-24-39(33,34)9)17-20-31-25-32(41-43(10,11)37(3,4)5)26-36(28(31)2)42-44(12,13)38(6,7)8/h16-17,20,23,27,30,32-34,36H,2,14-15,18-19,21-22,24-26H2,1,3-13H3/b23-16+,29-17+,31-20+/t27-,32-,33-,34+,36+,39-/m1/s1

Sinonimi:

• 1(S),3(R).20(R)-Bis(Tert-Butyldimethylsilyloxy)-20-(3'-Cyclopropyl-3'-Oxyprop-1'(E)-Enyl)-9,10-Secopregna-5(E),10(19)Triene
• 2-Penten-1-one, 4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-, (2E,4R)-
• (1a,3b,5E,7E,22E)-24-Cyclopropyl-1,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9,10-secochola-5,7,10(19),22-tetraen-24-one
• Calcipotriol Intermediate 9
• Calcipotriol Impurity 11
• Calcipotriol (Calcipotriene) intermediate
• (R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldiMethylsilyloxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one
• (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
• (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert...
• InterMediate G6/(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)diMethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
• (5E)-1,3-Bis-O-(tert-Butyldimethylsilyl)-24-oxo-calcipotriene

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one

CAS: 112849-17-9

Formula: C₃₉H₆₆O₃Si₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 639.1105

Ref: IN-DA007S3T

(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one

CAS: 112849-17-9

(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one

Purezza: 98%

Peso molecolare: 639.11g/mol

Ref: 54-OR1034319

(R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one

CAS: 112849-17-9

Purezza: 98%

Peso molecolare: 639.1240234

Ref: 10-F788743

(5E)-1,3-Bis-O-(tert-Butyldimethylsilyl)-24-oxo-calcipotriene

Prodotto controllato

CAS: 112849-17-9

Applications Intermediate in the preparation of Vitamin D (V676040) analogs.
References Xu, W. et al.: Org. Lett., 12, 4431 (2010); Calverley, M.J.: Tetrahedron, 43, 4609 (1987)

Formula: C₃₉H₆₆O₃Si₂

Colore e forma: Neat

Peso molecolare: 639.11

Ref: TR-B691900