CAS 113852-37-2

Cidofovir

Descrizione:

Cidofovir è un farmaco antivirale utilizzato principalmente nel trattamento della retinite da citomegalovirus (CMV) in pazienti affetti da AIDS. È un analogo nucleotidico della citosina, che inibisce la DNA polimerasi virale, impedendo così la replicazione virale. Cidofovir è caratterizzato dalla sua elevata potenza contro una gamma di virus a DNA, inclusi gli herpesvirus. Il composto viene tipicamente somministrato per via endovenosa a causa della sua scarsa biodisponibilità orale. Ha una emivita relativamente lunga, consentendo una somministrazione meno frequente rispetto ad altri agenti antivirali. Si sa che Cidofovir ha effetti nefrotossici, richiedendo un attento monitoraggio della funzione renale durante il trattamento. Inoltre, spesso viene co-somministrato con probenecid per mitigare la nefrotossicità riducendo la secrezione tubulare renale. La sostanza è classificata come farmaco da prescrizione e non è raccomandata per l'uso in donne in gravidanza a causa di potenziali effetti teratogeni. In generale, Cidofovir rappresenta un'opzione terapeutica critica per la gestione di infezioni virali gravi in pazienti immunocompromessi.

Formula: C₈H₁₄N₃O₆P

InChI: InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)

InChI key: InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

SMILES: C([C@H](OCP(=O)(O)O)CO)N1C(=O)N=C(N)C=C1

Sinonimi:

• (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
• (S)-Hpmpc
• ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine
• 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
• Cidofovir (anhydrous)
• Cidofovir monophosphate
• Cidovir
• Gs 0504
• Hpmpc
• P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-
• Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Unii-768M1V522C
• Vistide
• {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid
• (S)-1-[3-HYDROXY-2-(PHOSPHONYL-METHOXY)PROPYL]-CYTOSINE
• (S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• GS-504
• [[(S)-2-[(4-Amino-2-oxo-1,2-dihydropyrimidin)-1-yl]-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• [1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
• CIDOFOVIR
• CIDOFOVIR, S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• (S)-[[2-(4-Amino-2-oxo-1(2H)pyrimidinyl)-l-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• 1-[(2S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine

[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 279.1870

Ref: IN-DA00393G

Cidofovir, anhydrous

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Peso molecolare: 297.20

Ref: 7W-GP4917

Cidofovir

CAS: 113852-37-2

Cidofovir

Purezza: ≥98%

Peso molecolare: 279.19g/mol

Ref: 54-BUP10119

Cidofovir

CAS: 113852-37-2

Cidofovir

Purezza: 98%

Peso molecolare: 279.19g/mol

Ref: 54-OR1026524

Cidofovir hydrate

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P·xH₂O

Purezza: 98.0 - 102.0 % (dried basis)

Colore e forma: White or off-white crystalline powder

Peso molecolare: 279.19 (anhydrous)

Ref: 7W-GP0753

Cidofovir

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Colore e forma: Neat

Peso molecolare: 279.19

Ref: 04-C11666335

Cidofovir

Prodotto controllato

CAS: 113852-37-2

Formula: C₈H₁₄N₃O₆P

Colore e forma: Neat

Peso molecolare: 279.19

Ref: 86-MM3558.00

Cidofovir

CAS: 113852-37-2

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

Formula: C₈H₁₄N₃O₆P

Purezza: 99.24% - 99.76%

Colore e forma: Fluffy White Powder

Peso molecolare: 279.19

Ref: TM-T6244

Cidofovir Hydrate

CAS: 113852-37-2

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
References Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);

Formula: C₈H₁₄N₃O₆P

Colore e forma: White Powder

Peso molecolare: 279.19

Ref: TR-C433500

Cidofovir anhydrous - Bio-X ™

CAS: 113852-37-2

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis.

Formula: C₈H₁₄N₃O₆P

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 279.19 g/mol

Ref: 3D-BC164304

Cidofovir (anhydrous)

CAS: 113852-37-2

Anti-viral; DNA polymerase inhibitor

Formula: C₈H₁₄N₃O₆P

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 279.19 g/mol

Ref: 3D-FC46273