CAS 113866-14-1

BOC-GRR-AMC

Descrizione:

BOC-GRR-AMC, con il numero CAS 113866-14-1, è un composto chimico che funge da substrato in saggi biochimici, in particolare nello studio delle proteasi. È caratterizzato dalla presenza di un gruppo protettivo BOC (tert-butilossicarbonile), comunemente usato nella sintesi peptidica per proteggere i gruppi amminici. La sequenza GRR indica la presenza di aminoacidi specifici, probabilmente arginina e glicina, che possono essere rilevanti per la specificità enzimatica. Il gruppo AMC (7-amino-4-metilcumarina) è un gruppo fluorogeno che emette fluorescenza al momento della scissione, rendendolo utile per monitorare l'attività enzimatica in tempo reale. Questo composto è tipicamente utilizzato in contesti di ricerca per indagare l'attività proteolitica e la cinetica enzimatica. La sua stabilità, solubilità in solventi organici e la capacità di fornire un segnale fluorescente misurabile durante la reazione lo rendono uno strumento prezioso nella ricerca biochimica e farmaceutica. Condizioni adeguate di manipolazione e stoccaggio sono essenziali per mantenere la sua integrità e reattività.

Formula: C₂₉H₄₄N₁₀O₇

Sinonimi:

• T-Butyloxycarbonylglycyl-L-Arginyl-L-Arginine 4-Methylcoumaryl-7-Amide
• Boc-Gly-Arg-Arg-Mca
• Boc-Gly-Arg-Arg-Amc
• tert-butyl N-[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate
• BOC-GRR-AMC
• L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• TERT-BUTYLOXYCARBONYL-GLYCYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE

Boc-Gly-Arg-Arg-AMC

CAS: 113866-14-1

A substrate for flavivirus proteases such as West Nile virus protease, yellow fever virus NS3 protease, and dengue virus NS2B-NS3 protease.Boc-GRR-AMC is cleaved by type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana. Stock solutions of Boc-GRR-AMC are best prepared in DMSO.

Formula: C₂₉H₄₄N₁₀O₇

Purezza: 98.7%

Colore e forma: White Powder

Peso molecolare: 644.73

Ref: 01-4017086

Boc-Gly-Arg-Arg-AMC acetate salt

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC acetate salt is a protease inhibitor that inhibits the activity of serine proteases. This protein is a potent and selective inhibitor of the NS3 protease from hepatitis C virus, which is responsible for the cleavage of polyproteins into mature proteins. Boc-Gly-Arg-Arg-AMC acetate salt has been shown to be effective in transfection experiments and polymerase chain reaction, as well as in inhibiting the activity of soybean trypsin and mammalian tissue proteases.

Formula: C₂₉H₄₄N₁₀O₇•(C₂H₄O₂)x

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 644.72 g/mol

Ref: 3D-FB110553

Boc-Gly-Arg-Arg-AMC

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC is a research tool that has a high purity and is used in cell biology, antibody production, ion channels, and protein interactions. It is an inhibitor of ion channels, which can be used for pharmacology to study the function of ion channels. Boc-Gly-Arg-Arg-AMC has also been shown to inhibit binding between the ligand and receptor.

Formula: C₂₉H₄₄N₁₀O₇

Purezza: Min. 95%

Peso molecolare: 644.72 g/mol

Ref: 3D-MGR-3142-V

Boc-Gly-Arg-Arg-AMC trifluoroacetate

CAS: 113866-14-1

Boc-Gly-Arg-Arg-AMC trifluoroacetate is a potent inhibitor of kinases, which are enzymes that play a crucial role in various cellular processes. It has been shown to effectively inhibit the activity of both Chinese and human kinases. This inhibitor has also demonstrated its efficacy as an anticancer agent by inducing apoptosis in cancer cells. Boc-Gly-Arg-Arg-AMC trifluoroacetate is a medicinal protein analog that can be used for the development of novel inhibitors with improved potency and selectivity. Its potential therapeutic applications make it a promising candidate for cancer treatment. Additionally, this compound can be detected in urine, making it an excellent biomarker for kinase activity in vivo.

Formula: C₂₉H₄₄N₁₀O₇•(C₂HF₃O₂)x

Purezza: Min. 95%

Colore e forma: Powder

Ref: 3D-BB183183