CAS 1140909-48-3

cabozantinib (S)-malato

Descrizione:

cabozantinib (S)-malato è un inibitore di piccole molecole utilizzato principalmente nella terapia del cancro, in particolare per il trattamento del carcinoma renale avanzato e del carcinoma epatocellulare. Funziona come un inibitore della tirosina chinasi, mirando a molteplici vie coinvolte nella crescita tumorale e nella metastasi, inclusi MET, VEGFR e AXL. La forma (S)-malato indica che il composto è un sale derivato dall'acido malico, che ne migliora la solubilità e la biodisponibilità. Il cabozantinib presenta una struttura complessa che include un nucleo centrale con vari gruppi funzionali, contribuendo alla sua attività farmacologica. Il composto viene tipicamente somministrato per via orale e ha un profilo farmacocinetico specifico, comprese caratteristiche di assorbimento, distribuzione, metabolismo ed escrezione che sono cruciali per la sua efficacia terapeutica. Gli effetti collaterali possono includere disturbi gastrointestinali, affaticamento e ipertensione, riflettendo il suo meccanismo d'azione sulle vie vascolari e cellulari. In generale, cabozantinib (S)-malato rappresenta un significativo progresso nelle terapie mirate contro il cancro, offrendo un approccio multifaccettato per inibire la progressione tumorale.

Formula: C₃₂H₃₀FN₃O₁₀

InChI: InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

InChI key: InChIKey=HFCFMRYTXDINDK-WNQIDUERSA-N

SMILES: C(NC1=CC=C(OC=2C3=C(C=C(OC)C(OC)=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4.[C@H](CC(O)=O)(C(O)=O)O

Sinonimi:

• (2S)-2-Hydroxybutanedioic acid compd.with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide(1:1)
• (2S)-2-hydroxybutanedioic acid
• Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
• Cabozantinib L-(-)-Apple Acid
• Cabozantinib L-Malate
• Cabozantinib Malate
• Cometriq
• N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide mono[(2S)-2-hydroxybutanedioate]
• N1-[4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N1'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• Xl 184
• Cabozantinib S-malate
• Cabozantinib S-malate
• Cabozantinib L-Malate Salt
• N-[4-[(6,7-DiMethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide (2S)-
• Cabozantinib (S)-Malate(XL-184)
• Cabozantinib Malate (XL184)
• XL184(S)-malate
• Cabozantinib malate, >=99%
• Cabozantinib (S)-malate (2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
• Smalate
• XL184(Cabozantinib malate)
• XL-184 (Malate)

Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)

CAS: 1140909-48-3

Formula: C₃₂H₃₀FN₃O₁₀

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 635.5931

Ref: IN-DA000AJ8

Cabozantinib S-malate

CAS: 1140909-48-3

Cabozantinib S-malate

Purezza: ≥98%

Peso molecolare: 635.59g/mol

Ref: 54-BUP15407

Cabozantinib (S)-Malate

CAS: 1140909-48-3

Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 501.51 134.09

Ref: 4Z-C-284013

Cabozantinib (S)-Malate

CAS: 1140909-48-3

Colore e forma: Neat

Ref: 86-MM3947.00

Cabozantinib S-malate

CAS: 1140909-48-3

Cabozantinib S-malate (XL184) is the salt form of cabozantinib, an orally bioavailable, small molecule RTK inhibitor with potential antineoplastic activity.

Formula: C₃₂H₃₀FN₃O₁₀

Purezza: 98% - >99.99%

Colore e forma: Solid

Peso molecolare: 635.59

Ref: TM-T1797

Cabozantinib malate

CAS: 1140909-48-3

Formula: C₃₂H₃₀FN₃O₁₀

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 635.59

Ref: 7W-GP4726

Cabozantinib (Phenylene-d4) L-Malate Salt

Prodotto controllato

CAS: 1140909-48-3

Applications Cabozantinib-d4 L-Malate Salt, is the labeled analogue of Cabozantinib L-Malate Salt (C051500), which is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),

Formula: C₂₈D₄H₂₀FN₃O₅·C₄H₆O₅

Colore e forma: Neat

Peso molecolare: 639.62

Ref: TR-C051502

Cabozantinib L-Malate Salt

Prodotto controllato

CAS: 1140909-48-3

Applications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),

Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Colore e forma: Neat

Peso molecolare: 635.59

Ref: TR-C051500

Cabozantinib malate

CAS: 1140909-48-3

Inhibits MET, VEGFR1, VEGFR2; VEGFR3 receptor tyrosine kinases; antineoplastic

Formula: C₂₈H₂₄FN₃O₅·C₄H₆O₅

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 635.6 g/mol

Ref: 3D-FC64967