CAS 114899-77-3

Trabectedina

Descrizione:

Trabectedina, noto anche con il suo codice di sviluppo ET-743, è un alcaloide sintetico derivato dalla tunicata marina Ecteinascidia turbinata. Viene utilizzato principalmente come agente antineoplastico nella terapia del cancro, in particolare per i sarcomi dei tessuti molli e il cancro ovarico. Trabectedina agisce legandosi al DNA e interrompendo il processo di trascrizione, portando all'arresto del ciclo cellulare e all'apoptosi nelle cellule tumorali. Il suo meccanismo d'azione implica la formazione di adotti di DNA, che interferiscono con la normale funzione della macchina cellulare. Il composto presenta una struttura unica caratterizzata da un nucleo policiclico complesso e una catena laterale funzionalizzata, contribuendo alla sua attività biologica. Trabectedina viene somministrato per via endovenosa e ha un profilo farmacocinetico specifico, inclusa una vita media relativamente breve e un'ampia legame alle proteine. Gli effetti collaterali possono includere mielosoppressione, elevazione degli enzimi epatici e disturbi gastrointestinali. A causa della sua origine e meccanismo unici, Trabectedina rappresenta un significativo progresso nelle terapie mirate contro il cancro, evidenziando il potenziale dei composti derivati dal mare nella chimica medicinale.

Formula: C₃₉H₄₃N₃O₁₁S

InChI: InChI=1/C40H45N3O11S/c1-17-11-21-12-23-38(47)43-24-15-51-39(48)40(22-14-26(49-5)25(45)13-20(22)7-9-41-40)8-10-55-37(31(43)30(42(23)4)27(21)32(46)33(17)50-6)29-28(24)36-35(52-16-53-36)18(2)34(29)54-19(3)44/h11,13-14,23-24,30-31,37-38,41,45-47H,7-10,12,15-16H2,1-6H3/t23-,24-,30+,31+,37+,38-,40+/m0/s1

InChI key: InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N

SMILES: O[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]

Sinonimi:

• (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-Trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydrospiro(6,16-(epithiopropanooxymethano)-7,13-imino-6aH-1,3-dioxolo(7,8)isoquino(3,2-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-5-yl acetate
• (1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one
• 1,3-Benzodioxole-5-propanoic acid,7-methyl-6-(phenylmethoxy)-α-[[(phenylmethoxy)carbonyl]amino]-,2,2-dimethoxyethyl ester
• Ccris 8133
• Ect 743
• Ecteinascidin
• Ecteinascidine 743
• Et-743
• Nsc 648766
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-
• Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, (1′R,6R,6aR,7R,13S,14S,16R)-
• Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, 5-(acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-, [6R-(6α,6aβ,7β,13β,14β,16α,20R*)]-
• Trabectedin
• Unii-Id0Yzq2Tcp
• Yondelis
• ecteinascidin 743
• ecteinascidin 743,Trabectedin,ET 743
• Trabectedin Q: What is the storage condition of
• PKVRCIRHQMSYJX-ZKZLGIKISA-N
• (1'R,6R,6aR,7R,13S,14S,16R)-
• Trabectedin Q: What is the CAS Number of
• ASMF Filed
• NSC-684766
• ECTEINASCIDIN 743; ET-743; ECTEINASCIDIN
• Trabectedin (Ecteinascidin 743)
• Trabectedin Q: What are the applications of
• Trabectedin (Yondelis)
• Yondelis R ,Trabectedin
• TrabectedinQ: What is
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743)
• Trabectedin, >95%
• Trabectedin(Ecteinascidin 743,NSC-684766,ET-743, Yondelis)
• cteinascidin

ecteinascidin 743

CAS: 114899-77-3

Formula: C₃₉H₄₃N₃O₁₁S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 761.8372

Ref: IN-DA008TKA

Trabectedin

CAS: 114899-77-3

Trabectedin

Purezza: ≥98%

Peso molecolare: 761.84g/mol

Ref: 54-BUP12778

Trabectedin

CAS: 114899-77-3

Formula: C₃₉H₄₃N₃O₁₁S

Peso molecolare: 761.84

Ref: 4Z-T-298001

Trabectedin

CAS: 114899-77-3

Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research.

Formula: C₃₉H₄₃N₃O₁₁S

Purezza: ≥98%

Colore e forma: Solid

Peso molecolare: 761.84

Ref: TM-T17155

Trabectedin

Prodotto controllato

CAS: 114899-77-3

Applications A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.
References Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456 (1992), Aune, G., et al.: Anticancer Drugs, 13, 545 (2002), Herrero, A., et al.: Cancer Res., 66, 8155 (2006), Sugasawa, K., et al.: Carcinogenesis, 29, 455 (2008),

Formula: C₃₉H₄₃N₃O₁₁S

Colore e forma: Neat

Peso molecolare: 761.84

Ref: TR-T703500

Trabectedin

CAS: 114899-77-3

Trabectedin is a model system for investigating the role of protein genes in cancer. It is used for high throughput screening of potential biomarkers, such as blood sampling and mouse tumor models. Trabectedin has been shown to be a potent inhibitor of the p-gp substrate and has been used in vivo to treat cancers, including solid tumors and experimental models. This drug was also found to inhibit the antitumor response in normal human cells. Trabectedin is a taxane derivative that binds to the surface of cells with high affinity and prevents phosphorylation of proteins on the cell surface, which leads to inhibition of cell proliferation.

Formula: C₃₉H₄₃N₃O₁₁S

Purezza: Min. 95%

Colore e forma: White/Off-White Solid

Peso molecolare: 761.84 g/mol

Ref: 3D-FT28354