CAS 114977-28-5

Taxotere

Descrizione:

Taxotere, con il numero CAS 114977-28-5, è un agente chemioterapico utilizzato principalmente nel trattamento di vari tumori, tra cui il cancro al seno, ai polmoni e alla prostata. Il suo principio attivo è il docetaxel, un derivato semisintetico del paclitaxel. Taxotere funge da inibitore dei microtubuli, interrompendo la normale funzione del fuso mitotico durante la divisione cellulare, inibendo così la proliferazione delle cellule tumorali. La sostanza viene tipicamente somministrata per via endovenosa ed è nota per la sua efficacia in combinazione con altri agenti chemioterapici. Taxotere è caratterizzata dalla sua solubilità in solventi organici e la sua formulazione spesso include polisorbato 80 per migliorare la solubilità in soluzioni acquose. Gli effetti collaterali comuni associati a Taxotere includono neutropenia, affaticamento, nausea e alopecia, tra gli altri. A causa dei suoi potenti effetti, è classificato come un agente antineoplastico ed è soggetto a un attento monitoraggio durante il trattamento per gestire le potenziali reazioni avverse.

Formula: C₄₃H₅₃NO₁₄

InChI: InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41-,42-,43+/m0/s1

InChI key: InChIKey=ZDZOTLJHXYCWBA-VCVYQWHSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinonimi:

• (1beta,2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Ati 1123
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bind-014
• Ckd 810
• Crlx 301
• Decetaxel anhydrous
• Docefrez
• Docetaxel
• Docetaxel Anhydrous
• Docetaxol
• Docetere
• Duopafei
• Miradocetaxel
• N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol
• N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
• Rp 56976
• Sid 530
• Taxotel
• docetaxcel，DTX
• )benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
• TAXOTERE
• DOCETAXEL (TAXOTERE)
• Docetaxel9.5%
• Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
• Docetaxel99.5%
• DOCETAXEL TRIHYDRATE
• DocetaxelAnhydrous/Trihydrate
• beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
• n-debenzoyl-n-(tert-butoxycarbonyl)taxol
• o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
• rp56976
• DocetaxelAnhydrousin-HouseStandard
• benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
• DOCETAXEL ANHYDROUS 99.5%
• -,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 807.89

Ref: 3B-D4102

Docetaxel, 99%

CAS: 114977-28-5

Docetaxel, 114977-28-5, is a taxoid antineoplastic agent and a second-generation cytotoxic antimicrotubule agent. Learn more at Thermo Fisher Scientific.

Formula: C₄₃H₅₃NO₁₄

Purezza: 99%

Peso molecolare: 807.89

Ref: 02-J60174

ANHYDROUS DOCETAXEL CRS

CAS: 114977-28-5

ANHYDROUS DOCETAXEL CRS

Formula: C₄₃H₅₃NO₁₄

Colore e forma: Crystalline Powder. White. Powder.

Peso molecolare: 807.8792

Ref: 41-Y0001466

Docetaxel

CAS: 114977-28-5

Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM).

Formula: C₄₃H₅₃NO₁₄

Purezza: 98.6% - 99.29%

Colore e forma: Off-White Cryst

Peso molecolare: 807.88

Ref: TM-T1034

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Purezza: %

Colore e forma: Solid

Peso molecolare: 807.8792

Ref: IN-DA0039I1

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄·xH₂O

Purezza: ≤ 0.1%

Colore e forma: White to off-white crystalline powder

Peso molecolare: 807.88 (anhydrous)

Ref: 7W-GP5102

Docetaxel

CAS: 114977-28-5

Docetaxel

Formula: C₄₃H₅₃NO₁₄

Purezza: >99%

Colore e forma: white crystalline solid or powder

Peso molecolare: 807.87922g/mol

Ref: 54-BID2710

Docetaxel

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 807.89

Ref: 4Z-D-191

Docetaxel Anhydrous

Prodotto controllato

CAS: 114977-28-5

Formula: C₄₃H₅₃NO₁₄

Colore e forma: Neat

Peso molecolare: 807.88

Ref: 86-MM3390.00

Docetaxel

CAS: 114977-28-5

Docetaxel is an antineoplastic drug by inhibiting microtubule depolymerization, and attenuating of the effects of bcl-2 and bcl-xL gene expression.

Formula: C₄₃H₅₃NO₁₄

Purezza: 95%~99%

Peso molecolare: 807.89

Ref: BP-BP0514

Docetaxel Anhydrous

CAS: 114977-28-5

Colore e forma: Neat

Ref: 61-FOR3390.00

Docetaxel

CAS: 114977-28-5

Applications Docetaxel is an antimitotic Taxol analog antibiotic.

Formula: C₄₃H₅₃NO₁₄

Colore e forma: Off White Solid

Peso molecolare: 807.88

Ref: TR-D525623

Docetaxel

CAS: 114977-28-5

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Formula: C₄₃H₅₃NO₁₄

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 807.88 g/mol

Ref: 3D-FD10817

Docetaxel - Bio-X ™

CAS: 114977-28-5

Docetaxel is an antineoplastic agent that is used to treat various cancers such as breast and prostate cancer. This drug interferes with the normal function of microtubule growth. It is an anti-mitotic drug used in chemotherapy. Research has shown that this drug also induces programmed cell death in cancer cells.

Formula: C₄₃H₅₃NO₁₄

Purezza: Min. 90 Area-%

Colore e forma: White/Off-White Solid

Peso molecolare: 807.88 g/mol

Ref: 3D-BD164373