CAS 115268-43-4

(1R,3S,7S,8S,10S,12S,18R)-7-Idrossi-12-[1(S)-idrossi-3-[4-metil-3,6-diidro-2H-pirano-2(S)-il]-2(E)-propenil]-3-metil-5-metilene-9,13,22-triossatriciclo[16.3.1.0(8,10)]docosa-15,19-dien-14-one

Descrizione:

La sostanza chimica con il nome "(1R,3S,7S,8S,10S,12S,18R)-7-Idrossi-12-[1(S)-idrossi-3-[4-metil-3,6-diidro-2H-pirano-2(S)-il]-2(E)-propenil]-3-metil-5-metilene-9,13,22-triossatriciclo[16.3.1.0(8,10)]docosa-15,19-dien-14-one" e numero CAS "115268-43-4" è un composto organico complesso caratterizzato dalla sua intricatissima stereochimica e da molteplici gruppi funzionali. Presenta una struttura triciclica con diversi gruppi idrossilici, che contribuiscono alla sua potenziale reattività e solubilità in solventi polari. La presenza di un gruppo propenile e di una porzione di pirano indica che potrebbe partecipare a varie reazioni chimiche, comprese quelle tipiche dei composti insaturi. I suoi molteplici anelli e gruppi funzionali suggeriscono che potrebbe mostrare interessanti attività biologiche, rendendolo potenzialmente rilevante nella ricerca farmacologica. La stereochimica specifica implica che potrebbe avere interazioni distinte con bersagli biologici, il che è cruciale per le sue potenziali applicazioni in chimica medicinale. In generale, questo composto esemplifica la complessità spesso riscontrata nei prodotti naturali e nelle molecole organiche sintetiche.

Formula: C₃₀H₄₂O₇

InChI: InChI=1S/C30H42O7/c1-19-12-13-34-23(15-19)10-11-25(31)27-18-28-30(37-28)26(32)17-21(3)14-20(2)16-24-8-4-6-22(35-24)7-5-9-29(33)36-27/h4-6,9-12,20,22-28,30-32H,3,7-8,13-18H2,1-2H3/b9-5-,11-10+/t20-,22-,23+,24-,25-,26-,27-,28-,30-/m0/s1

InChI key: InChIKey=MSBQEQDLFWWWMV-XZZGLLCESA-N

SMILES: O[C@@H]1[C@]2([C@@](O2)(C[C@@]([C@H](/C=C/[C@@H]3CC(C)=CCO3)O)(OC(=O)/C=C\C[C@]4(O[C@](C[C@@H](C)CC(=C)C1)(CC=C4)[H])[H])[H])[H])[H]

Sinonimi:

• (-)-Laulimalide
• (1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-Dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one
• 9,13,22-Trioxatricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one, 12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-, (1R,3S,7S,8S,10S,12S,15Z,18R)-
• 9,13,22-Trioxatricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one, 12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propenyl]-7-hydroxy-3-methyl-5-methylene-, (1R,3S,7S,8S,10S,12S,15Z,18R)-
• 9,13,22-Trioxatricyclo[16.3.1.0^8,10]docosa-15,19-dien-14-one, 12-[3-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-1-hydroxy-2-propenyl]-7-hydroxy-3-methyl-5-methylene-, [1R-[1R*,3S*,7S*,8S*,10S*,12S*[1S*,2E,3(S*)],15Z,18R*]]-
• Er 806782
• Fijianolide B
• 9,13,22-Trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one, 12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propenyl]-7-hydroxy-3-methyl-5-methylene-, (1R,3S,7S,8S,10S,12S,15Z,18R)-
• 9,13,22-Trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one, 12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-, (1R,3S,7S,8S,10S,12S,15Z,18R)-
• (1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-Dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one
• 9,13,22-Trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one, 12-[3-(3,6-dihydro-4-methyl-2H-pyran-2-yl)-1-hydroxy-2-propenyl]-7-hydroxy-3-methyl-5-methylene-, [1R-[1R*,3S*,7S*,8S*,10S*,12S*[1S*,2E,3(S*)],15Z,18R*]]-

Laulimalide

CAS: 115268-43-4

Microtubule stabilizer; halts cancer cell growth (IC50: 3-30 nM); arrests cells in prometaphase; prevents bipolar spindle formation.

Formula: C₃₀H₄₂O₇

Colore e forma: Solid

Peso molecolare: 514.65

Ref: TM-T37063