CAS 115966-23-9

Urodilatina

Descrizione:

Urodilatina è un peptide derivato dalla pro-ormone pro-peptide natriuretico atriale (pro-ANP) ed è principalmente coinvolto nella regolazione della funzione renale e dell'equilibrio dei fluidi. È caratterizzato dal suo ruolo di agente natriuretico, promuovendo l'escrezione di sodio e acqua, il che aiuta a ridurre il volume sanguigno e abbassare la pressione arteriosa. Urodilatina è prodotto nei reni e agisce sui tubuli renali, aumentando la diuresi e la natriuresi. La sua struttura consiste in una sequenza di amminoacidi che conferiscono la sua attività biologica, ed è noto per interagire con recettori specifici nel corpo, portando a vasodilatazione e aumento della velocità di filtrazione glomerulare. Il potenziale terapeutico di Urodilatina è in fase di esplorazione in condizioni come l'insufficienza cardiaca e l'ipertensione, dove il sovraccarico di fluidi è una preoccupazione. In generale, le sue proprietà uniche lo rendono una molecola importante nella fisiologia cardiovascolare e renale.

Formula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

InChI: InChI=1/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1

Sinonimi:

• Anp 95-126
• H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)
• Proatrial natriuretic peptide (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human)
• Urodilatin
• Urodilatin (CDD/ANP-95-126)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE
• URODILATIN CCC/ANP, 95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide, Urodilatin, human
• H-THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR-OH (DISULFIDE BRIDGE: 11-27)
• Urodilatin CCC
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR(DISULFIDE BRIDGE CYS11- CYS 27)
• TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY (DISULFIDE BRIDGE: 11-27)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE HUMAN
• THR-ALA-PRO-ARG-ANP, HUMAN
• CCC/ANP-95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (huMan, bovine, porcine)
• URODILATIN HUMAN
• URODILATIN (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR
• Urodilatin, Ularitide
• CDD/ANP-95-126

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine)

CAS: 115966-23-9

Urodilatin, a 32 amino acid peptide, has originally been isolated from human urine. It belongs to the family of natriuretic-vasorelaxant peptides earlier found in heart atria. Cedidi et al. showed that urodilatin infusion may represent a concept for the treatment of therapy-resistant acute renal failure after liver transplantation. The use of ularitide is protected by patents. It is sold by Bachem for research purposes only, by expressed permission of Pharis Biotec GmbH, Hannover, Germany (www.pharis-biotec.com).

Formula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Purezza: ≥ 95%

Colore e forma: White Powder

Peso molecolare: 3505.98

Ref: 01-4030382

Urodilatin

CAS: 115966-23-9

Formula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Purezza: 95%

Peso molecolare: 3505.9265

Ref: IN-DA000H8N

Urodilatin

CAS: 115966-23-9

Urodilatin, an analogue of ANF-(99-126), serves as a diuretic-natriuretic regulatory peptide with applications in the study of acute renal failure, congestive

Colore e forma: Solid

Ref: TM-T80891

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt

CAS: 115966-23-9

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt is a peptide hormone that regulates blood pressure by causing the kidneys to excrete sodium and water. It is used as a model system for studying the physiological effects of urodilatin and has been shown to inhibit the cyclase enzyme. Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt may also have an antihypertensive effect through its ability to reduce levels of natriuretic peptides in plasma. This drug is also being investigated as a possible treatment for congestive heart failure. The small molecular weight makes it suitable for use as a natriuretic or antihypertensive drug with minimal side effects.

Formula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Purezza: Min. 95%

Peso molecolare: 3,505.93 g/mol

Ref: 3D-FT108857