CAS 117977-21-6

Rabeprazolo-tioetere

Descrizione:

Rabeprazolo-tioetere è un derivato del rabeprazolo, un inibitore della pompa protonica comunemente usato per trattare condizioni come la malattia da reflusso gastroesofageo (GERD) e le ulcere peptiche. Questo composto presenta un gruppo funzionale tioetere, che può influenzare le sue proprietà farmacologiche, inclusa la solubilità e la stabilità metabolica. Il rabeprazolo stesso è noto per la sua capacità di inibire l'enzima H+/K+ ATPasi nelle cellule parietali gastriche, riducendo così la secrezione di acido gastrico. La modifica tioetere può migliorare la sua biodisponibilità o alterare la sua interazione con i bersagli biologici. Tipicamente, composti come Rabeprazolo-tioetere sono caratterizzati dal loro peso molecolare, formula strutturale e specifici gruppi funzionali, che contribuiscono alla loro reattività chimica ed efficacia terapeutica. Inoltre, la stabilità del composto, la solubilità in vari solventi e i potenziali effetti collaterali sono caratteristiche importanti che vengono spesso valutate durante lo sviluppo di farmaci e l'uso clinico. In generale, Rabeprazolo-tioetere rappresenta una modifica mirata a ottimizzare gli effetti terapeutici del rabeprazolo minimizzando potenzialmente gli effetti avversi.

Formula: C₁₈H₂₁N₃O₂S

InChI: InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)

InChI key: InChIKey=BSXAHDOWMOSVAP-UHFFFAOYSA-N

SMILES: S(CC1=C(C)C(OCCCOC)=CC=N1)C=2NC=3C(N2)=CC=CC3

Sinonimi:

• 1H-Benzimidazole,2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-
• 2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
• 2-[((4-(3-Methoxypropoxy)-3-methylpyridine-2-yl)methyl)thio]-1H-benzimidazole
• 2-[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole
• 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole
• 2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole
• 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
• H 295/43
• Rabeprazole-thioether

Rabeprazole Sulfide

CAS: 117977-21-6

Formula: C₁₈H₂₁N₃O₂S

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 343.45

Ref: 3B-R0098

Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)

CAS: 117977-21-6

Aromatic or modified aromatic heterocyclic compounds wi

Formula: C₁₈H₂₁N₃O₂S

Colore e forma: White Off-White Powder

Peso molecolare: 343.13545

Ref: 45-1598064

2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Formula: C₁₈H₂₁N₃O₂S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 343.4432

Ref: IN-DA007QM8

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Methylthio}-1H-Benzimidazole

CAS: 117977-21-6

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Methylthio}-1H-Benzimidazole

Purezza: 98%

Peso molecolare: 343.44g/mol

Ref: 54-OR1010226

Rabeprazole EP Impurity B (Rabeprazole Sulfide)

CAS: 117977-21-6

Formula: C₁₈H₂₁N₃O₂S

Colore e forma: White To Off-White Solid

Peso molecolare: 343.45

Ref: 4Z-R-205

Rabeprazole Sulfide

CAS: 117977-21-6

Rabeprazole Sulfide

Purezza: ≥98%

Peso molecolare: 343.44g/mol

Ref: 54-BUP17604

2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole

Prodotto controllato

CAS: 117977-21-6

Colore e forma: Neat

Ref: 86-MM0618.02

Rabeprazole Sulfide

CAS: 117977-21-6

Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.

Formula: C₁₈H₂₁N₃O₂S

Purezza: 99.34% - 99.78%

Colore e forma: Off-White Crystalline Powder

Peso molecolare: 343.44

Ref: TM-T1734

Rabeprazole Sulfide

CAS: 117977-21-6

Impurity Rabeprazole EP Impurity B
Applications Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).
References Yoshida, T., et al.: Biotech. Lett., 23, 1217 (2001), Miura, M., et al.: Eur. J. Clin. Pharmacol., 62, 113 (2006), Sheridan, R.P., et al.: J. Med. Chem., 50, 3173 (2007), Ren, S., et al.: Arc. Pharm. Res., 31, 406 (2008),

Formula: C₁₈H₂₁N₃O₂S

Colore e forma: Neat

Peso molecolare: 343.45

Ref: TR-R070510

Rabeprazole EP Impurity B

CAS: 117977-21-6

Formula: C₁₈H₂₁N₃O₂S

Peso molecolare: 343.44

Ref: ST-EA-CP-R5002

2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 343.45001220703125

Ref: 10-F078879

2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-1H-benzimidazole

CAS: 117977-21-6

Rabeprazole is a proton pump inhibitor that is used to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcers. Rabeprazole inhibits the production of gastric acid by blocking the hydrogen/potassium ATPase that is found in the parietal cells of the stomach. The main mechanism of action for rabeprazole is competitive inhibition of the proton pump, which leads to decreased gastric acid secretion. Rabeprazole can be administered orally or intravenously, with a half-life of about 2 hours. It has been shown to have an effect on human liver cytochrome P450s, but does not affect the activity of recombinant cytochrome P450 3A4 (CYP3A4). In clinical studies, rabeprazole was shown to have no adverse effects on CYP3A4 activity and may even increase it slightly.

Formula: C₁₈H₂₁N₃O₂S

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 343.44 g/mol

Ref: 3D-IM57863

Rabeprazole-D4 Sulfide

Prodotto controllato

CAS: 117977-21-6

Applications Rabeprazole-D4 Sulfide is an intermediate in the synthesis of Rabeprazole-d4 (R070492). Rabeprazole-D4 Sulfide is an isotope-labeled analogue of Rabeprazole Sulfide (Rabeprazole EP Impurity B), which is a metabolite of Rabeprazole (R070500).
References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)

Formula: C₁₈D₄H₁₇N₃O₂S

Colore e forma: Neat

Peso molecolare: 347.468

Ref: TR-R070511