CAS 118414-82-7

MK-886

Descrizione:

MK-886, con il numero CAS 118414-82-7, è un composto sintetico che funge principalmente da inibitore selettivo dell'enzima 5-lipossigenasi (5-LO). Quest'enzima gioca un ruolo cruciale nella biosintesi dei leucotrieni, che sono mediatori infiammatori coinvolti in varie condizioni patologiche, tra cui asma e altre malattie infiammatorie. MK-886 è caratterizzato dalla sua capacità di modulare le risposte infiammatorie, rendendolo un argomento di interesse nella ricerca farmacologica. Il composto è tipicamente studiato per le sue potenziali applicazioni terapeutiche nel trattamento di condizioni associate a una produzione eccessiva di leucotrieni. In termini di struttura chimica, MK-886 presenta un'architettura distintiva di gruppi funzionali che contribuiscono alla sua attività biologica. È importante notare che, sebbene MK-886 abbia mostrato promesse negli studi preclinici, sono necessarie ulteriori ricerche per comprendere appieno la sua efficacia, il profilo di sicurezza e le potenziali applicazioni cliniche. Come molti composti investigativi, il suo utilizzo è principalmente confinato a contesti di ricerca fino a quando non saranno disponibili dati clinici più definitivi.

Formula: C₂₇H₃₃ClNO₂S·Na

InChI: InChI=1/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31)

InChI key: InChIKey=QAOAOVKBIIKRNL-UHFFFAOYSA-N

SMILES: C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(C(C)C)=CC2)C3=CC=C(Cl)C=C3

Sinonimi:

• 1-((4-Chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
• 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
• 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid
• 3-[3-(butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• L 663536
• MK 886
• MK 886
• CGS-81585
• 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
• 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt
• MK866
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
• MK-886 (L-663,536)
• MK-886 (Free Base)

1H-Indole-2-propanoic acid,1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-

CAS: 118414-82-7

Formula: C₂₇H₃₄ClNO₂S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 472.0824

Ref: IN-DA008RN6

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

CAS: 118414-82-7

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

Purezza: 98%

Peso molecolare: 472.08g/mol

Ref: 54-OR1026587

MK-886

CAS: 118414-82-7

MK-886

Purezza: ≥98%

Peso molecolare: 472.08g/mol

Ref: 54-BUP07765

MK-886

CAS: 118414-82-7

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

Formula: C₂₇H₃₄ClNO₂S

Purezza: 99.23% - 99.84%

Colore e forma: Solid

Peso molecolare: 472.08

Ref: TM-T6893

MK-886

CAS: 118414-82-7

MK-886 is a synthetic compound, formally classified as a leukotriene biosynthesis inhibitor, which is derived through chemical synthesis processes. This compound acts by specifically targeting the 5-lipoxygenase-activating protein (FLAP), a crucial component in the leukotriene synthesis pathway. By inhibiting FLAP, MK-886 effectively suppresses the production of leukotrienes, which are lipid compounds that play a pivotal role in the inflammatory response.

Formula: C₂₇H₃₄ClNO₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 472.08 g/mol

Ref: 3D-TEA41482

MK 886 - Bio-X ™

CAS: 118414-82-7

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.

Formula: C₂₇H₃₄ClNO₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 472.08 g/mol

Ref: 3D-BM166037

MK-886

Prodotto controllato

CAS: 118414-82-7

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

Formula: C₂₇H₃₄ClNO₂S

Colore e forma: Neat

Peso molecolare: 472.08

Ref: TR-M425053