CAS 118506-26-6

Proteina Basica della Mielina (87-99) (umano, bovino, ratto)

Descrizione:

La proteina basica della mielina (MBP) è un componente cruciale della guaina mielinica che isola le fibre nervose nel sistema nervoso centrale. Il frammento specifico denominato 'Proteina Basica della Mielina (87-99)' corrisponde a una sequenza peptidica derivata dalla proteina a lunghezza completa, che gioca un ruolo significativo nella formazione e nel mantenimento della mielina. Questa proteina è caratterizzata dalla sua alta basicità, grazie alla presenza di numerosi amminoacidi carichi positivamente, che facilita la sua interazione con i lipidi caricati negativamente nella membrana mielinica. La MBP è essenziale per il corretto funzionamento degli oligodendrociti, le cellule responsabili della mielinizzazione nel sistema nervoso centrale. È anche coinvolta in vari processi cellulari, inclusi segnalazione e organizzazione del citoscheletro. Il numero CAS 118506-26-6 identifica questo specifico peptide, che può essere derivato da varie specie, tra cui umani, bovini e ratti, riflettendo la sua conservazione evolutiva e importanza tra diversi organismi. La ricerca sulla MBP è significativa per comprendere le malattie demielinizzanti, come la sclerosi multipla, in cui il sistema immunitario attacca erroneamente la mielina.

Formula: C₇₄H₁₁₄N₂₀O₁₇

Sinonimi:

• Myelin Basic Protein (87-99), Guinea Pig, Human
• Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro
• Vhffknivtprtp
• Mbp (Human, Bovine, Rat)
• Mbp (87-99) Human
• H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-Oh (Human, Bovine, Rat)

Myelin Basic Protein (87-99)

CAS: 118506-26-6

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.
Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.
Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Formula: C₇₄H₁₁₄N₂₀O₁₇

Purezza: Min. 95%

Peso molecolare: 1,555.86 g/mol

Ref: 3D-PMB-3973-PI

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₇₄H₁₁₄N₂₀O₁₇

Peso molecolare: 1,555.84 g/mol

Ref: 3D-PP49994

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

Please enquire for more information about Myelin Basic Protein (87-99) (human, bovine, rat) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₇₄H₁₁₄N₂₀O₁₇

Purezza: Min. 95%

Peso molecolare: 1,555.82 g/mol

Ref: 3D-FM108566

Myelin Basic Protein (87-99) (human, bovine, rat)

CAS: 118506-26-6

This MBP fragment has been shown to induce the proliferation of an encephalitogenic, myelin basic protein-specific T cell line. Active immunization of rats with this peptide induced acute experimental autoimmune encephalomyelitis. This protein region is highly conserved among mammalian species.

Formula: C₇₄H₁₁₄N₂₀O₁₇

Purezza: 100%

Colore e forma: White Lyophilisate

Peso molecolare: 1555.84

Ref: 01-4025349