CAS 1187594-09-7

Baricitinib

Descrizione:

Baricitinib è un farmaco a piccole molecole utilizzato principalmente per il trattamento dell'artrite reumatoide da moderata a grave. Funziona come un inibitore selettivo delle enzimi Janus chinasi (JAK), specificamente JAK1 e JAK2, che svolgono un ruolo cruciale nelle vie di segnalazione di varie citochine coinvolte nei processi infiammatori. La formula chimica di Baricitinib è C16H17N3O2 e ha un peso molecolare di circa 285,33 g/mol. La sostanza appare come una polvere cristallina bianca a bianco sporco ed è solubile in dimetilsolfossido (DMSO) e leggermente solubile in acqua. Baricitinib viene somministrato per via orale e ha dimostrato di ridurre i segni e i sintomi dell'artrite reumatoide modulando la risposta immunitaria. La sua farmacocinetica indica una vita media relativamente lunga, consentendo una somministrazione una volta al giorno. Come con qualsiasi farmaco, gli effetti collaterali potenziali includono un aumento del rischio di infezioni, elevazioni degli enzimi epatici e cambiamenti nei conteggi delle cellule del sangue, richiedendo monitoraggio durante il trattamento.

Formula: C₁₆H₁₇N₇O₂S

InChI: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

InChI key: InChIKey=XUZMWHLSFXCVMG-UHFFFAOYSA-N

SMILES: C(C#N)C1(CN(S(CC)(=O)=O)C1)N2C=C(C=N2)C3=C4C(=NC=N3)NC=C4

Sinonimi:

• 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
• 2-(3-(4-(3H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
• 2-(3-(4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
• 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-
• Incb 028050
• Incb 28050
• Incb028050
• Ly 3009104
• Ly3009104
• Olumiant
• Baricitinib
• 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile Baricitinib (LY3009104, INCB028050)
• Baricitinib(INCB 028050
• aricitinib (LY3009104, INCB028050)
• Baricitinib (LY3009104)
• Baricitinib/INCB 028050/LY3009104
• Baricitinib (LY3009104, INCB028050)

1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

CAS: 1187594-09-7

Formula: C₁₆H₁₇N₇O₂S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 371.4169

Ref: IN-DA003A5U

Baricitinib

CAS: 1187594-09-7

Baricitinib

Purezza: ≥98%

Peso molecolare: 371.42g/mol

Ref: 54-BUP15488

Baricitinib

CAS: 1187594-09-7

Formula: C₁₆H₁₇N₇O₂S

Colore e forma: White To Off-White Solid

Peso molecolare: 371.42

Ref: 4Z-B-154001

Baricitinib

CAS: 1187594-09-7

Colore e forma: Neat

Ref: 86-MM3905.00

Baricitinib

CAS: 1187594-09-7

Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.

Formula: C₁₆H₁₇N₇O₂S

Purezza: 99% - >99.99%

Colore e forma: Solid

Peso molecolare: 371.42

Ref: TM-T2485

Baricitinib

CAS: 1187594-09-7

Formula: C₁₆H₁₇N₇O₂S

Purezza: ≥ 98.0%

Colore e forma: White to off-white solid

Peso molecolare: 371.4

Ref: 7W-GW9910

Baricitinib

Prodotto controllato

CAS: 1187594-09-7

Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);

Formula: C₁₆H₁₇N₇O₂S

Colore e forma: White Solid

Peso molecolare: 371.42

Ref: TR-B118690

Baricitinib

CAS: 1187594-09-7

Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.

Formula: C₁₆H₁₇N₇O₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 371.42 g/mol

Ref: 3D-FE30357

Baricitinib - Bio-X ™

CAS: 1187594-09-7

Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.
Baricitinib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₆H₁₇N₇O₂S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 371.42 g/mol

Ref: 3D-BB184033

BARICITINIB

CAS: 1187594-09-7

Formula: C₁₆H₁₇N₇O₂S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 371.42

Ref: 10-F468368

Baricitinib Azetidine-d4

Prodotto controllato

CAS: 1187594-09-7

Formula: C₁₆H₁₃D₄N₇O₂S

Colore e forma: Neat

Peso molecolare: 375.44

Ref: TR-B118694