CAS 1190308-01-0

PSI-7976

CAS: 1190308-01-0

Formula: C₂₂H₂₉FN₃O₉P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 529.4525

Ref: IN-DA008TJ5

Sofosbuvir Impurity 19

CAS: 1190308-01-0

Formula: C₂₂H₂₉FN₃O₉P

Colore e forma: White To Off-White Solid

Peso molecolare: 529.46

Ref: 4Z-S-055021

PSI-7976

CAS: 1190308-01-0

PSI-7976

Purezza: 98%

Peso molecolare: 529.45g/mol

Ref: 54-PC1008076

Sofosbuvir (R)-Phosphate

CAS: 1190308-01-0

Formula: C₂₂H₂₉FN₃O₉P

Peso molecolare: 529.5

Ref: ST-EA-CP-S45017

PSI-7976

CAS: 1190308-01-0

Purezza: 98%

Peso molecolare: 529.458

Ref: 10-F987616

Sofosbuvir (R)-Phosphate

CAS: 1190308-01-0

Applications Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

Formula: C₂₂H₂₉FN₃O₉P

Colore e forma: Neat

Peso molecolare: 529.45

Ref: TR-S675615

PSI 7976

CAS: 1190308-01-0

PSI 7976 is an analog of the nucleophilic attack drug, ribavirin. PSI 7976 inhibits the hepatitis C virus (HCV) replicon by inhibiting the function of the NS5B polymerase. In clinical studies, PSI 7976 has been shown to be active against HCV genotype 1 and 3. It has also been shown to inhibit replication of HIV-1 in vitro and to act synergistically with lamivudine against HIV-1 in human cells. PSI 7976 may be useful as a potential antiviral agent for treatment of other viral infections such as hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), or cytomegalovirus (CMV).

Formula: C₂₂H₂₉FN₃O₉P

Purezza: Min. 95%

Peso molecolare: 529.45 g/mol

Ref: 3D-IP102673