CAS 120202-71-3

(R)-Clopidogrel bisolfato

Descrizione:

(R)-Clopidogrel bisolfato è un farmaco antipiastrinico utilizzato principalmente per prevenire la formazione di coaguli di sangue nei pazienti con malattie cardiovascolari. È un pro-farmaco che richiede attivazione metabolica per esercitare i suoi effetti terapeutici, inibendo specificamente il recettore P2Y12 sulle piastrine, prevenendo così l'aggregazione piastrinica. Il composto è caratterizzato dalla sua natura chirale, con l'enantiomero (R) che è la forma attiva responsabile della sua attività farmacologica. Il bisolfato di clopidogrel viene tipicamente somministrato per via orale ed è ben assorbito nel tratto gastrointestinale, sebbene la sua biodisponibilità sia influenzata dal metabolismo di primo passaggio. La sostanza è spesso formulata come un sale di bisolfato per migliorare la sua solubilità e stabilità. Gli effetti collaterali comuni includono complicazioni emorragiche, disturbi gastrointestinali e, in rari casi, reazioni di ipersensibilità. A causa del suo meccanismo d'azione, è fondamentale monitorare i pazienti per segni di sanguinamento, specialmente quando usato in concomitanza con altri anticoagulanti o agenti antipiastrinici. In generale, (R)-Clopidogrel bisolfato gioca un ruolo significativo nella gestione dei disturbi trombotici.

Formula: C₁₆H₁₆ClNO₂S·H₂O₄S

InChI: InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m1./s1

InChI key: InChIKey=FDEODCTUSIWGLK-XFULWGLBSA-N

SMILES: [C@@H](C(OC)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.S(=O)(=O)(O)O

Sinonimi:

• (R)-(-)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate bisulfate
• (R)-(-)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogen sulfate
• (R)-Clopidogrel bisulfate
• (R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
• Clopidogrel Related Compound C
• Methyl(-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate
• Sr 25989C
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αR)-, sulfate (1:1)
• methyl (2R)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate sulfate

Clopidogrel Related Compound C (methyl (-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate)

CAS: 120202-71-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₆H₁₆ClNO₂S·H₂SO₄

Colore e forma: White Powder

Peso molecolare: 321.05903

Ref: 45-1140600

(R)-Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7h)-yl)acetate sulfate

CAS: 120202-71-3

Formula: C₁₆H₁₈ClNO₆S₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 419.9002

Ref: IN-DA0081B8

Clopidogrel EP Impurity C Sulfate (Clopidogrel USP Related Compound C, (R)-Clopidogrel Sulfate)

CAS: 120202-71-3

Formula: C₁₆H₁₆ClNO₂S·H₂SO₄

Colore e forma: White To Off-White Solid

Peso molecolare: 321.82 98.07

Ref: 4Z-C-1314

Clopidogrel Related Compound C

CAS: 120202-71-3

Clopidogrel Related Compound C

Purezza: ≥95%

Peso molecolare: 419.89g/mol

Ref: 54-BUP18818

Methyl (2R)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetate Hydrogen Sulfate ((R)-Clopidogrel Hydrogen Sulfate)

CAS: 120202-71-3

Colore e forma: Neat

Ref: 86-MM0455.12

Clopidogrel Related Compound C

CAS: 120202-71-3

(R)-Clopidogrel bisulfate (Clopidogrel Related Compound C) is an isomer of clopidogrel. Clopidogrel is a P2Y12 receptor antagonist.

Formula: C₁₆H₁₈ClNO₆S₂

Purezza: 97.84%

Colore e forma: Solid

Peso molecolare: 419.9

Ref: TM-T126236

R-(-)-Clopidogrel Hydrogen Sulfate

Prodotto controllato

CAS: 120202-71-3

Impurity Clopidogrel EP Impurity C
Stability Very Hygroscopic
Applications R-(-)-Clopidogrel Hydrogen Sulfate (Clopidogrel EP Impurity C) is used as an antithrombotic. Clopidogrel Related Compound C
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)

Formula: C₁₆H₁₆ClNO₂S·H₂O₄S

Colore e forma: White

Peso molecolare: 419.9

Ref: TR-C587251

Clopidogrel EP Impurity C

CAS: 120202-71-3

Formula: C₁₆H₁₆ClNO₂SH₂O₄S

Peso molecolare: 321.8 : 98.1

Ref: ST-EA-CP-C2003

R-(-)-Clopidogrel hydrogen sulfate

CAS: 120202-71-3

R-(-)-Clopidogrel hydrogen sulfate is a prodrug of clopidogrel, which is an antiplatelet agent. It is used to prevent thrombotic events in people with coronary artery disease, peripheral arterial disease, or cerebrovascular disease. The drug is broken down in the liver and then converted to an active form by the enzyme CYP2C19. The R-(-)-isomer of clopidogrel has been shown to be more effective for reducing platelet aggregation than its S-enantiomer, with no difference in effectiveness between the two forms for reducing heart attacks and strokes. This drug can be found in wastewater samples due to its use as a therapeutic agent. The method used for analysis was LC-MS/MS and the excipients were not reported.

Formula: C₁₆H₁₈ClNO₆S₂

Purezza: Min. 98 Area-%

Colore e forma: White Slightly Yellow Powder

Peso molecolare: 419.02641

Ref: 3D-FC20512