CAS 120993-53-5

Desirudina

Descrizione:

Desirudina è un anticoagulante sintetico che appartiene alla classe degli inibitori diretti della trombina. È utilizzato principalmente nella prevenzione e nel trattamento della tromboembolia venosa, in particolare nei pazienti sottoposti a interventi chirurgici ortopedici. Desirudina agisce legandosi specificamente alla trombina, inibendo la sua attività e prevenendo così la conversione del fibrinogeno in fibrina, che è un passaggio cruciale nel processo di coagulazione del sangue. La sostanza è caratterizzata da una emivita relativamente breve, il che richiede una dosaggio e somministrazione accurati, spesso tramite iniezione sottocutanea. Desirudina è solubile in acqua, il che facilita il suo utilizzo in contesti clinici. La sua farmacocinetica può essere influenzata da fattori come la funzione renale, rendendo il monitoraggio importante in alcune popolazioni di pazienti. Come con altri anticoagulanti, esiste un rischio di sanguinamento e il suo utilizzo richiede una considerazione attenta delle potenziali interazioni farmacologiche e controindicazioni. In generale, Desirudina rappresenta un'importante opzione terapeutica nella gestione dei disturbi trombotici.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₀S₆

InChI: InChI=1/C287H440N80O110S6/c1-25-133(19)226-281(470)345-161(87-125(3)4)235(424)306-111-208(395)320-180(116-370)266(455)344-175(101-219(415)416)237(426)307-105-202(389)316-151(62-75-212(401)402)242(431)321-145(41-30-33-81-288)240(429)339-170(96-197(297)384)258(447)326-152(57-70-193(293)380)249(438)351-185(121-481-478-118-182-239(428)310-107-201(388)313-147(55-68-191(291)378)232(421)303-108-205(392)317-169(95-196(296)383)257(446)322-146(42-31-34-82-289)241(430)350-186(271(460)360-226)122-482-479-119-183(268(457)323-149(61-74-211(399)400)234(423)304-110-207(394)319-179(115-369)265(454)342-173(99-200(300)387)264(453)357-223(130(13)14)279(468)355-182)352-253(442)164(90-128(9)10)335-269(458)184-120-480-483-123-187(354-262(451)177(103-221(419)420)347-283(472)230(137(23)374)362-263(452)167(93-141-49-53-144(377)54-50-141)346-278(467)224(131(15)16)359-276(465)222(301)129(11)12)272(461)363-229(136(22)373)282(471)330-157(66-79-216(409)410)248(437)348-178(114-368)238(427)309-106-203(390)315-150(56-69-192(292)379)243(432)340-171(97-198(298)385)259(448)334-163(89-127(7)8)252(441)353-184)270(459)358-225(132(17)18)280(469)364-228(135(21)372)277(466)311-112-204(391)314-148(60-73-210(397)398)233(422)305-113-209(396)356-231(138(24)375)286(475)367-86-38-46-190(367)275(464)331-159(43-32-35-83-290)284(473)365-84-36-44-188(365)273(462)328-153(58-71-194(294)381)247(436)349-181(117-371)267(456)338-168(94-142-104-302-124-312-142)256(445)341-172(98-199(299)386)260(449)343-174(100-218(413)414)236(425)308-109-206(393)318-176(102-220(417)418)261(450)337-165(91-139-39-28-27-29-40-139)254(443)327-154(63-76-213(403)404)244(433)325-158(67-80-217(411)412)250(439)361-227(134(20)26-2)285(474)366-85-37-45-189(366)274(463)329-156(65-78-215(407)408)245(434)324-155(64-77-214(405)406)246(435)336-166(92-140-47-51-143(376)52-48-140)255(444)333-162(88-126(5)6)251(440)332-160(287(476)477)59-72-195(295)382/h27-29,39-40,47-54,104,124-138,145-190,222-231,368-377H,25-26,30-38,41-46,55-103,105-123,288-290,301H2,1-24H3,(H2,291,378)(H2,292,379)(H2,293,380)(H2,294,381)(H2,295,382)(H2,296,383)(H2,297,384)(H2,298,385)(H2,299,386)(H2,300,387)(H,302,312)(H,303,421)(H,304,423)(H,305,422)(H,306,424)(H,307,426)(H,308,425)(H,309,427)(H,310,428)(H,311,466)(H,313,388)(H,314,391)(H,315,390)(H,316,389)(H,317,392)(H,318,393)(H,319,394)(H,320,395)(H,321,431)(H,322,446)(H,323,457)(H,324,434)(H,325,433)(H,326,447)(H,327,443)(H,328,462)(H,329,463)(H,330,471)(H,331,464)(H,332,440)(H,333,444)(H,334,448)(H,335,458)(H,336,435)(H,337,450)(H,338,456)(H,339,429)(H,340,432)(H,341,445)(H,342,454)(H,343,449)(H,344,455)(H,345,470)(H,346,467)(H,347,472)(H,348,437)(H,349,436)(H,350,430)(H,351,438)(H,352,442)(H,353,441)(H,354,451)(H,355,468)(H,356,396)(H,357,453)(H,358,459)(H,359,465)(H,360,460)(H,361,439)(H,362,452)(H,363,461)(H,364,469)(H,397,398)(H,399,400)(H,401,402)(H,403,404)(H,405,406)(H,407,408)(H,409,410)(H,411,412)(H,413,414)(H,415,416)(H,417,418)(H,419,420)(H,476,477)/t133-,134-,135+,136+,137+,138+,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187-,188-,189-,190-,222-,223-,224-,225-,226-,227-,228-,229-,230-,231-/m0/s1

Sinonimi:

• Desirudin [USAN:INN]
• 63-Desulfohirudin (Hirudo medicinalis isoform HV1)
• Cgp 39393
• Iprivask
• Revasc
• Unii-U0Jz726775
• Hirudin (Hirudo medicinalis isoform HV1), 63-desulfo-

Desirudin

CAS: 120993-53-5

Desirudin is a recombinant human coagulation factor that has been used as an anticoagulant in patients with liver impairment. Desirudin is a single-chain polypeptide composed of the signal peptide and the active protein, which is cleaved from the pro-protein during translation. The activity of desirudin is dependent on intramolecular hydrogen bonding and it inhibits thrombin by binding to its active site. Desirudin has been shown to have a protective effect against experimental myocardial infarction in rats with congestive heart failure. This drug also has pharmacokinetic properties that are dependent on body mass index and glomerular filtration rate, which may affect its efficacy in patients with different conditions.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₀S₆

Purezza: Min. 95%

Peso molecolare: 6,963.43 g/mol

Ref: 3D-FD170616

Desirudin

CAS: 120993-53-5

Desirudin (CGP 39393) inhibits thrombin, prevents thrombosis, and is used in thrombocytopenia research.

Colore e forma: Solid

Ref: TM-T64250