CAS 1217731-56-0

Abacavir-d4 (cyclopropyl-2,2,3,3-d4)

CAS: 1217731-56-0

Purezza: 99 atom % D

Peso molecolare: 290.36

Ref: 3U-D8039

Abacavir-d4

Prodotto controllato

CAS: 1217731-56-0

Stability Very Hygroscopic
Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₁₄D₄N₆O

Colore e forma: Off-White

Peso molecolare: 290.36

Ref: TR-A105002

Abacavir-d4

Prodotto controllato

CAS: 1217731-56-0

Abacavir-d4 is a deuterium-labeled analogue of the antiretroviral medication Abacavir. It serves as a critical tool for pharmaceutical research and development. This isotopically labeled compound is synthesized by incorporating four deuterium atoms into the molecular structure of Abacavir, preserving the pharmacokinetic and pharmacodynamic properties of the original molecule while allowing for precise analytical quantification.

Formula: C₁₄H₁₄D₄N₆O

Purezza: Min. 95%

Peso molecolare: 290.36 g/mol

Ref: 3D-SYB73156