CAS 122018-58-0

PLP (139-151)

Descrizione:

PLP, o fosfato di piridossale, è la forma attiva della vitamina B6 e svolge un ruolo cruciale come coenzima in varie reazioni biochimiche, in particolare nel metabolismo degli aminoacidi. È caratterizzato dalla sua capacità di partecipare a reazioni di transaminazione, decarbossilazione e racemizzazione, facilitando la conversione degli aminoacidi e la sintesi dei neurotrasmettitori. La sostanza è una polvere cristallina gialla solubile in acqua e presenta un profilo di stabilità dipendente dal pH, risultando più stabile in condizioni neutre o leggermente alcaline. Il PLP è essenziale per il corretto funzionamento degli enzimi coinvolti nel metabolismo di carboidrati, lipidi e aminoacidi, rendendolo vitale per numerosi processi fisiologici. La carenza di PLP può portare a vari problemi di salute, tra cui anemia e disturbi neurologici. Il suo numero CAS, 122018-58-0, lo identifica in modo univoco nei database chimici, aiutando nella ricerca e nei contesti normativi. In generale, il PLP è un composto biochimico significativo con ruoli diversi nella salute umana e nel metabolismo.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Sinonimi:

• Proteolipid Protein
• Myelin Proteolipid Protein Fragment (139-151)
• (Ser140)-Myelin Proteolipid Protein (139-151), Depalmitoylated, Human, Bovine, Dog, Mouse, Rat
• [Ser140]-Myelin Proteolipid Protein (139-151) (Human, Bovine, Dog, Mouse, Rat)
• H2N-Hslgkwlghpdkf-Oh

(Ser¹⁴⁰)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)

CAS: 122018-58-0

This fragment of myelin proteolipid protein is an encephalitogenic determinant, able to bind to diverse sets of T cell receptors.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purezza: 97.0%

Colore e forma: White

Peso molecolare: 1521.74

Ref: 01-4030575

[SER140]-PLP(139-151)

CAS: 122018-58-0

[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1521.72

Ref: TM-TP1312

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) is derived from Proteolipid Protein (PLP), an epitope of immunodominant encephalitogenic PLP and is involved in promoting encephalomyelitis.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 1,520.8 g/mol

Ref: 3D-CRB1000865

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) peptide is a fragment of myelin proteolipid protein (PLP or lipophilin), from amino acid residue 139 to 151 (HCLGKWLGHPDKF – CAS 131334-43-5 ). Myelin proteolipid protein is the major myelin protein from the central nervous system. PLP (139-151) peptide is commonly used to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. The PLP (139-151) peptide C140S is mutant of the wild-type version where the cystein is replaced by a serine to make the peptide more stable without impacting its antigenic activity.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Peso molecolare: 1,521.7 g/mol

Ref: 3D-PP50157

Myelin PLP (139-151)

CAS: 122018-58-0

Myelin PLP (139-151) is a basic protein that belongs to the family of oligodendrocyte-myelin glycoproteins. It has been shown to activate toll-like receptor, which is a pattern recognition receptor that recognizes invading pathogens and triggers an immune response. Myelin PLP (139-151) may play a role in the development of autoimmune diseases, as it has been found to be a target for autoantibodies. It has also been shown to have antioxidative properties, which may help prevent free radical damage in the brain and other tissues. The monoclonal antibody against this protein can be used for immunohistological analysis.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purezza: Min. 95%

Peso molecolare: 1,521.72 g/mol

Ref: 3D-PLP-3812-PI

Myelin PLP (139-151) acetate

CAS: 122018-58-0

Myelin PLP (139-151) acetate salt is a cyclic peptide that is derived from the sequence of human myelin basic protein and contains the sequence PLP (139-151). This peptide has shown to have antioxidative properties. It has been shown to have an inhibitory effect on the production of proinflammatory cytokines in experimental autoimmune encephalomyelitis (EAE), which is a model for multiple sclerosis. The peptide has also been shown to block signal pathways, such as toll-like receptor 4, and decrease Ca2+ overload. Clinical relevance remains unclear.

Formula: C₇₂H₁₀₄N₂₀O₁₇•(C₂H₄O₂)x

Purezza: Min. 95%

Peso molecolare: 1,521.76 g/mol

Ref: 3D-PLP-3602-PI

(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt

CAS: 122018-58-0

Ser140-Myelin Proteolipid Protein (139-151) is an experimental autoimmune encephalomyelitis (EAE) adjuvant that is used to induce EAE in animals. The peptide has been shown to be mononuclear, encephalitogenic, and capable of inducing cell proliferation. Ser140-Myelin Proteolipid Protein (139-151) has been shown to induce EAE when injected into the animals with a pre-existing immunity to myelin basic protein. Ser140-Myelin Proteolipid Protein (139-151) is also mannosylated and can be used as an experimental adjuvant for immunization.

Formula: C₇₂H₁₀₄N₂₀O₁₇

Purezza: Min. 95%

Peso molecolare: 1,521.72 g/mol

Ref: 3D-FS108682