CAS 1227962-62-0

Maritoclax

CAS: 1227962-62-0

Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value

Formula: C₂₂H₁₂Cl₄N₂O₄

Purezza: 99.87%

Colore e forma: Solid

Peso molecolare: 510.15

Ref: TM-T11944

Methanone, 1,1'-(4,4',5,5'-tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-(2-hydroxyphenyl)-

CAS: 1227962-62-0

Formula: C₂₂H₁₂Cl₄N₂O₄

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 510.1537

Ref: IN-DA000JH5

Maritoclax

CAS: 1227962-62-0

Maritoclax

Purezza: ≥95%

Peso molecolare: 510.15g/mol

Ref: 54-BUP04291

Maritoclax

CAS: 1227962-62-0

Maritoclax is a low-potency, selective inhibitor of the mcl-1 protein. It has been shown to increase the sensitivity of leukemia cells to chemotherapy by inducing apoptosis in leukemia cells that express wild-type mcl-1 and chemoresistance in those that have mutated the protein. Maritoclax has also been shown to be effective against skin cancer in vivo, where it inhibits proliferation and induces apoptosis. In addition, maritoclax can induce apoptosis in primary cells from human patients with autoimmune diseases such as systemic lupus erythematosus. Mutations in cyclin D2 may lead to resistance to maritoclax treatment because the drug only works on cells with wild-type cyclin D2 expression. This drug may also be synergistic with other drugs that target cell proliferation, such as gemcitabine or cetuximab.

Formula: C₂₂H₁₂Cl₄N₂O₄

Purezza: Min. 95%

Peso molecolare: 510.15 g/mol

Ref: 3D-CZB96262