CAS 123318-82-1

Clofarabina

Descrizione:

Clofarabina è un analogo di nucleoside sintetico utilizzato principalmente nel trattamento della leucemia linfoblastica acuta (LLA) e della leucemia mieloide acuta (LMA). È caratterizzato dalla sua struttura, che include una base purinica e un gruppo zuccherino, modificati per migliorare la sua efficacia e stabilità. Clofarabina mostra proprietà antineoplastiche interferendo con la sintesi e la riparazione del DNA, portando infine all'apoptosi nelle cellule tumorali. Il suo meccanismo d'azione coinvolge l'inibizione della DNA polimerasi e della ribonucleotide reduttasi, che sono cruciali per i processi di replicazione e riparazione del DNA. Il composto è tipicamente somministrato per via endovenosa ed è noto per i suoi potenziali effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e infezioni dovute all'immunosoppressione. La farmacocinetica di Clofarabina indica una vita media relativamente breve, richiedendo un attento dosaggio e monitoraggio durante il trattamento. Nel complesso, rappresenta un significativo progresso nelle terapie mirate contro il cancro, in particolare per i pazienti con leucemia recidivante o refrattaria.

Formula: C₁₀H₁₁ClFN₅O₃

InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

InChI key: InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)=NC(Cl)=N1

Sinonimi:

• 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
• 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
• (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
• 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
• Clolar
• 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
• 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
• CAFDA
• 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
• Clofarabine
• 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
• Clofarex
• (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol

Clofarabine

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: >98.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 303.68

Ref: 3B-C2500

2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%

CAS: 123318-82-1

A purine nucleoside anti-metabolite. Toxic to nondividing lymphocytes and monocytes This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item c

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: 99+%

Peso molecolare: 303.68

Ref: 02-J60927

Clofarabine

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₀H₁₁ClFN₅O₃

Colore e forma: White Off-White Powder

Peso molecolare: 303.05345

Ref: 45-1138620

Clofarabine System Suitability Mixture (This is a mixture containing clofarabine and clofarabine α anomer)

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Colore e forma: White Solid

Ref: 45-1138621

(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 303.6774

Ref: IN-DA000KCJ

Clofarabine

CAS: 123318-82-1

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: 99.94% - >99.99%

Colore e forma: White Solid

Peso molecolare: 303.68

Ref: TM-T0297

Clofarabine

CAS: 123318-82-1

Clofarabine

Purezza: ≥98%

Peso molecolare: 303.68g/mol

Ref: 54-BUP15018

Clofarabine-13C-15N3

CAS: 123318-82-1

Formula: C₉₁₃CH₁₁ClFN₂₁₅N₃O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 307.65

Ref: 4Z-C-11508

Clofarabine

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Peso molecolare: 303.68

Ref: 7W-GP5199

Clofarabine

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 303.68

Ref: 4Z-C-11501

Clofarabine, free base

CAS: 123318-82-1

Clofarabine, free base

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: By hplc: 99.9% (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 303.68g/mol

Ref: 54-BIFK0045

Clofarabine

Prodotto controllato

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Colore e forma: Neat

Peso molecolare: 303.68

Ref: 86-MM3521.00

Clofarabine

CAS: 123318-82-1

Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

Formula: C₁₀H₁₁ClFN₅O₃

Colore e forma: White To Off-White

Peso molecolare: 303.68

Ref: TR-C586890

Clofarabine

CAS: 123318-82-1

Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: Min. 98 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 303.68 g/mol

Ref: 3D-NA07154

Clofarabine - Bio-X ™

CAS: 123318-82-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 303.68 g/mol

Ref: 3D-BC300153

CLOFARABINE

CAS: 123318-82-1

Formula: C₁₀H₁₁ClFN₅O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 303.68

Ref: 10-F387706