CAS 123524-52-7

Azelnidipina

Descrizione:

Azelnidipina è un bloccante dei canali del calcio utilizzato principalmente nel trattamento dell'ipertensione. Appartiene alla classe dei composti diidropiridinici, caratterizzati dalla loro capacità di inibire l'ingresso di calcio attraverso i canali del calcio di tipo L nel muscolo liscio vascolare e nel tessuto cardiaco. Questa azione porta a vasodilatazione e a una successiva riduzione della pressione sanguigna. Azelnidipina è noto per la sua lunga emivita, che consente una somministrazione una volta al giorno, migliorando la compliance del paziente. Il composto mostra selettività per i tessuti vascolari rispetto ai tessuti cardiaci, minimizzando potenziali effetti collaterali come la tachicardia riflessa. Inoltre, ha proprietà antiossidanti, che possono fornire ulteriori benefici cardiovascolari. Azelnidipina viene tipicamente somministrato nella sua forma di sale cloridrato ed è ben assorbito nel tratto gastrointestinale. La sua farmacocinetica può essere influenzata dall'assunzione di cibo e viene metabolizzato principalmente nel fegato. In generale, Azelnidipina rappresenta un'opzione preziosa nella terapia antipertensiva, particolarmente per i pazienti che richiedono una gestione a lungo termine dell'ipertensione.

Formula: C₃₃H₃₄N₄O₆

InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

InChI key: InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N

SMILES: C(OC1CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C1)(=O)C=4C(C(C(OC(C)C)=O)=C(C)NC4N)C5=CC(N(=O)=O)=CC=C5

Sinonimi:

• 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
• 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• Calblock
• Ccris 8650
• Cs 905
• Unii-Pv23P19Yug

3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 582.6463

Ref: IN-DA000KQ9

Azelnidipine

CAS: 123524-52-7

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Formula: C₃₃H₃₄N₄O₆

Purezza: 99.78%

Colore e forma: Light Yellowish Powder

Peso molecolare: 582.65

Ref: TM-T0121

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Colore e forma: Light Yellow Solid

Peso molecolare: 582.66

Ref: 4Z-A-10101

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Purezza: ≥98%

Peso molecolare: 582.65g/mol

Ref: 54-BUP13584

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Purezza: 99%

Peso molecolare: 582.65g/mol

Ref: 54-OR1028132

Azelnidipine-d7

CAS: 123524-52-7

Formula: C₃₃H₂₇D₇N₄O₆

Colore e forma: Yellow Solid

Peso molecolare: 589.70

Ref: 4Z-A-10102

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purezza: >98.0%(T)(HPLC)

Colore e forma: Light orange to Yellow to Green powder to crystal

Peso molecolare: 582.66

Ref: 3B-A2433

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purezza: (HPLC) ≥ 98.0%

Colore e forma: Off-white to light yellow powder

Peso molecolare: 582.65

Ref: 7W-GP5829

Azelnidipine

CAS: 123524-52-7

Azelnidipine is a drug that is used to treat high blood pressure and heart disease. It reduces the risk of cardiovascular events such as myocardial infarction and stroke. Azelnidipine has been shown to have an antioxidative effect, which may be due to its ability to decrease lipid peroxidation, increase superoxide dismutase activity, and inhibit the production of reactive oxygen species in a model of tubulointerstitial injury. The drug also inhibits calcium influx into cells by interfering with voltage-gated calcium channels. Azelnidipine binds reversibly to α1-acid glycoprotein, which is found in plasma and erythrocytes. This interaction may result in changes in renal function when combined with other drugs that bind the same protein (e.g., warfarin).

Formula: C₃₃H₃₄N₄O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 582.65 g/mol

Ref: 3D-FA18072

Azelnidipine

Prodotto controllato

CAS: 123524-52-7

Applications Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensice activity. Azelnidipine is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction. Studies show that Azelnidipine ttreatment can reduce the risk of hyperglycemia induced metabolic disorders
References Sugimoto, K. et al.: Int. J. Hypertens., No pp. (2010); Kain, V. et al.: Cardio. Diabetol., 9, 82 (2010); Kinouchi, K. et al.: Int. J. Hypertens., 284823, 11 (2011);

Formula: C₃₃H₃₄N₄O₆

Colore e forma: Yellow

Peso molecolare: 582.65

Ref: TR-A808500