CAS 123884-00-4

Dolastatina 15

Descrizione:

Dolastatina 15 è un peptide potente derivato dal mollusco marino Dolabella auricularia, noto per le sue significative proprietà antitumorali. Questo composto è caratterizzato dalla sua struttura complessa, che include una serie di aminoacidi che contribuiscono alla sua attività biologica. Dolastatina 15 mostra un meccanismo d'azione unico, principalmente inibendo l'assemblaggio dei microtubuli, interrompendo così la formazione del fuso mitotico durante la divisione cellulare. Questa azione lo rende un candidato per il trattamento del cancro, in particolare nel mirare a vari tipi di tumori. La sostanza è anche nota per la sua alta potenza e specificità, il che può portare a effetti collaterali ridotti rispetto agli agenti chemioterapici tradizionali. Inoltre, Dolastatina 15 è stato oggetto di ampie ricerche per esplorare il suo potenziale nello sviluppo di farmaci, sebbene la sua applicazione clinica sia ancora in fase di indagine. La sua stabilità, solubilità e biodisponibilità sono fattori critici che influenzano la sua efficacia terapeutica e formulazione in contesti farmaceutici. In generale, Dolastatina 15 rappresenta una promettente opportunità nella ricerca di terapie efficaci contro il cancro.

Formula: C₄₅H₆₈N₆O₉

InChI: InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc2)C(=CC1=O)OC)N=C([C@H](C(C)C)N(C)C)O

Sinonimi:

• (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl N-methyl-L-valyl-L-prolyl-2-{(2S)-2-[(N,N-dimethyl-L-valyl)amino]-3-methylbutanoyl}-L-prolinate
• 1-(2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N,N-dimethylvalylvalyl-N-methylvalylprolylprolinate
• (1S)-1-{[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}-2-methylpropyl N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinate
• DOLASTATIN 15
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
• (5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
• Nsc 617668

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED₅₀ value of 2.4 ng/mL.

Formula: C₄₅H₆₈N₆O₉

Purezza: 98.7%

Colore e forma: White Powder

Peso molecolare: 837.07

Ref: 01-4019226

L-Proline, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester

CAS: 123884-00-4

Formula: C₄₅H₆₈N₆O₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 837.0562

Ref: IN-DA000L75

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15, depsipeptide from Dolabella auricularia, is an ADC cytotoxin that induces apoptosis in myeloma cells.

Formula: C₄₅H₆₈N₆O₉

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 837.072

Ref: TM-T15158

Dolastatin 15

CAS: 123884-00-4

Formula: C₄₅H₆₈N₆O₉

Purezza: ≥ 95.0%

Colore e forma: White powder

Peso molecolare: 837.06

Ref: 7W-GP8277

Dolastatin 15

Prodotto controllato

CAS: 123884-00-4

Formula: C₄₅H₆₈N₆O₉

Colore e forma: Neat

Peso molecolare: 837.056

Ref: TR-D528508

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

CAS: 123884-00-4

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzylpyrrolidinium is a natural compound that has been isolated from the Indian Ocean sea hare Dolabella auricularia. It has shown significant cytotoxicity against cancer cells as well as significant immunosuppressive activities in animals. Dolastatin 15 is an analog of dolastatin 10 and has been shown to be active against hepatitis B and C virus. It also has antiinflammatory properties and may be effective in combating autoimmune diseases. The synthesis of this compound is an asymmetric synthesis with a hydroxyl group on one side of the molecule and an amide on the other side.

Formula: C₄₅H₆₈N₆O₉

Purezza: Min. 95%

Peso molecolare: 837.06 g/mol

Ref: 3D-FD110329