CAS 124-87-8

Picrotossina

Descrizione:

Picrotossina è un composto organico complesso classificato come composto biciclico ed è principalmente noto per il suo ruolo di neurotossina. Deriva dai semi della pianta Anamirta cocculus, comunemente nota come bacca di pesce o cocculus indicus. Picrotossina agisce come un antagonista non competitivo del recettore GABA_A, che è cruciale per la neurotransmissione inibitoria nel sistema nervoso centrale. Questa inibizione può portare a convulsioni e ad altri effetti neurologici, rendendo Picrotossina un potente agente convulsivo. La sostanza si presenta tipicamente come una polvere cristallina bianca ed è scarsamente solubile in acqua ma più solubile in solventi organici. A causa della sua natura tossica, Picrotossina è stato storicamente utilizzato nella ricerca per studiare i meccanismi della neurotransmissione e ha potenziali applicazioni in farmacologia. Tuttavia, il suo uso è limitato a causa di preoccupazioni di sicurezza ed è classificato come sostanza pericolosa. La corretta manipolazione e le precauzioni di sicurezza sono essenziali quando si lavora con Picrotossina in ambienti di laboratorio.

Formula: C₁₅H₁₈O₇·C₁₅H₁₆O₆

InChI: InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7-,8-,9-,13-,14-,15+;6-,7+,8-,9-,10-,13-,14-,15+/m11/s1

InChI key: InChIKey=VJKUPQSHOVKBCO-AHMKVGDJSA-N

SMILES: C[C@]12[C@@]34[C@](O3)(C[C@@]1(O)[C@@]5([C@H]([C@](C)(C)O)[C@]([C@]2(OC4=O)[H])(OC5=O)[H])[H])[H].C[C@]12[C@@]34[C@](O3)(C[C@@]1(O)[C@@]5([C@H](C(C)=C)[C@]([C@]2(OC4=O)[H])(OC5=O)[H])[H])[H]

Sinonimi:

• 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-, compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)
• 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-, [1aR-(1aα,2aβ,3β,6β,6aβ,8aS*,8bβ,9R*)]-, compd. with [1aR-(1aα,2aβ,3β,6β,6aβ,8aS*,8bβ,9S*)]-hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)
• 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, [1aR-(1aα,2aβ,3β,6β,6aβ,8aS*,8bβ,9S*)]-, compd. with [1aR-(1aα,2aβ,3β,6β,6aβ,8aS*,8bβ,9R*)]-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)
• Cocculin
• Fish berry
• Nsc 403139
• Picrotoxin
• Picrotoxina
• Picrotoxine
• Pikrotoxin
• 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-, compd. with (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1:1)

Picrotoxin (Picrotoxinin + Picrotin)

CAS: 124-87-8

Formula: C₃₀H₃₄O₁₃

Purezza: >94.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 602.59

Ref: 3B-C0375

Picrotoxin

CAS: 124-87-8

Formula: C₃₀H₃₄O₁₃

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 602.58

Ref: 7W-GK2155

Picrotoxin - Bio-X ™

CAS: 124-87-8

Picrotoxin is a GABA-A receptor antagonist that is used to relieve respiratory distress. This drug also is used as an antidote from poisoning by CNS depressants. Picrotoxin works by blocking the GABA activated chloride ionophore.

Formula: C₁₅H₁₈O₇·C₁₅H₁₆O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 602.58 g/mol

Ref: 3D-BP166191

Picrotoxin

CAS: 124-87-8

GABA(A) channel blocker

Formula: C₁₅H₁₈O₇•C₁₅H₁₆O₆

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 602.58 g/mol

Ref: 3D-FP52506

Picrotoxin (1:1 Mixture of Picrotoxinin and Picrotin)

Prodotto controllato

CAS: 124-87-8

Applications Picrotoxin is a equimolar mixture of Picrotoxinin and Picrotin. It is a GABAA receptor antagonist and potent CNS stimulant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dillon, G., et al.: 115, 539 (1995); Etter, A., et al.: J. Neurochem., 72, 318 (1999)

Formula: C₁₅H₁₆O₆C₁₅H₁₈O₇

Colore e forma: Neat

Peso molecolare: 602.58

Ref: TR-P437630

Picrotoxin pure, 98%

CAS: 124-87-8

Formula: C₃₀H₃₄O₁₃

Purezza: min. 98%

Colore e forma: White to off - white, Crystalline powder, Clear

Peso molecolare: 602.60

Ref: SR-93418