CAS 125-65-5

Pleuromutilina

Descrizione:

Pleuromutilina è un antibiotico naturale derivato dal fungo *Pleurotus mutilus*. Appartiene alla classe di composti noti come Pleuromutilinas, caratterizzati dalla loro struttura unica che include un sistema ad anello tetraciclico. Questo antibiotico mostra un'attività ad ampio spettro contro vari batteri Gram-positivi e alcuni batteri Gram-negativi, rendendolo efficace nel trattamento di infezioni causate da ceppi resistenti. Pleuromutilina funziona inibendo la sintesi proteica batterica, mirando specificamente al centro di trasferimento peptidico del ribosoma, il che interrompe il processo di traduzione. Il suo basso profilo di tossicità e l'efficacia hanno portato al suo sviluppo per uso clinico, in particolare nel trattamento di infezioni della pelle e dei tessuti molli. Inoltre, Pleuromutilina è stato modificato per creare derivati semisintetici, come la retapamulina, utilizzati in formulazioni topiche. La sostanza è tipicamente somministrata in modo controllato e la sua farmacocinetica è influenzata da fattori come la formulazione e la via di somministrazione. In generale, Pleuromutilina rappresenta un significativo progresso nella terapia antibiotica, specialmente di fronte all'aumento della resistenza agli antibiotici.

Formula: C₂₂H₃₄O₅

InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1

InChI key: InChIKey=ZRZNJUXESFHSIO-BKUNHTPHSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CO)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Sinonimi:

• (3aS,4R,5S,6S,8R,9S,9aR,10S)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
• 14-Deoxy-14-[(hydroxyacetyl)oxy]mutilin
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• 6-Ethenyl-5-Hydroxy-4,6,9,10-Tetramethyl-1-Oxodecahydro-3A,9-Propanocyclopenta[8]Annulen-8-Yl Hydroxyacetate
• Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-
• Antibiotic A 40104C
• Bc 757
• Drosophilin B
• Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one
• Mutilin 14-glycolate
• NSC 121145

Pleuromutilin

CAS: 125-65-5

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 378.509

Ref: 10-F987727

VALNEMULIN IMPURITY E CRS

CAS: 125-65-5

VALNEMULIN IMPURITY E CRS

Formula: C₂₂H₃₄O₅

Peso molecolare: 378.5024

Ref: 41-Y0000586

Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 378.5024

Ref: IN-DA00HHVG

Pleuromutilin

CAS: 125-65-5

Pleuromutilin

Purezza: ≥98%

Peso molecolare: 378.5g/mol

Ref: 54-BUP14420

Tiamulin EP Impurity G (Valnemulin EP Impurity E)

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Peso molecolare: 378.51

Ref: 4Z-T-9410

Pleuromutilin

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Purezza: ≥ 95.0%

Colore e forma: White to off-white or light yellow solid

Peso molecolare: 378.5

Ref: 7W-GA2930

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl Hydroxyacetate (Pleuromutilin)

Prodotto controllato

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Colore e forma: Neat

Peso molecolare: 378.50

Ref: 86-MM0394.10

Pleuromutilin

CAS: 125-65-5

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

Formula: C₂₂H₃₄O₅

Purezza: 97.321%

Colore e forma: Crystalline Solid

Peso molecolare: 378.5

Ref: TM-T16552

Pleuromutilin

Prodotto controllato

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Colore e forma: Neat

Peso molecolare: 378.50

Ref: TR-P610500

Pleuromulin

CAS: 125-65-5

The compound 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate is an antimicrobial agent that inhibits bacterial growth by binding to the disulfide bond of bacterial peptidoglycan. It is effective against a wide range of microorganisms including MRSA and methicillin resistant Enterococcus faecalis. The compound has shown efficacy in an animal model of chronic bronchitis caused by Streptococcus pneumoniae. The compound has a short half life and can be administered orally or intravenously with a pharmacokinetic profile that depends on the dose. This drug also has high resistance to β lactamase enzymes, which are found in some bacteria such as E. coli.

Formula: C₂₂H₃₄O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 378.5 g/mol

Ref: 3D-FP27100

Pleuromulin - Bio-X ™

CAS: 125-65-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₃₄O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 378.5 g/mol

Ref: 3D-BH300113

Tiamulin EP Impurity G

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Peso molecolare: 378.51

Ref: ST-EA-CP-T154005