CAS 125317-39-7: Navelbine

Descrizione: Navelbine, conosciuto con il nome generico vinorelbine, è un alcaloide della vinca semisintetico derivato dalla pianta pervinca, Catharanthus roseus. È utilizzato principalmente come agente chemioterapico nel trattamento di vari tumori, incluso il cancro ai polmoni non a piccole cellule e il cancro al seno. La vinorelbine agisce inibendo la formazione di microtubuli durante la divisione cellulare, interrompendo così il fuso mitotico e portando all'arresto del ciclo cellulare e all'apoptosi nelle cellule tumorali a rapida divisione. Il composto è tipicamente somministrato per via endovenosa e ha un profilo di effetti collaterali moderato, che può includere neutropenia, nausea e affaticamento. La sua farmacocinetica coinvolge il metabolismo epatico, principalmente attraverso il sistema del citocromo P450, ed è escreto principalmente nella bile. Il numero CAS 125317-39-7 identifica in modo univoco la vinorelbine nei database chimici, facilitando la ricerca e le applicazioni cliniche. In generale, Navelbine rappresenta un'importante opzione terapeutica in oncologia, contribuendo a migliorare i risultati nei pazienti con specifiche malignità.

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

InChI key: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: O=C(O)C(O)C(O)C(=O)O.O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CN9CC(=CC(C9)C6)CC)C)C

Sinonimi:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• Vinorelbine ditartrate

Vinorelbine for peak identification B CRS

CAS: 125317-39-7

• Colore e forma: Powder

Vinorelbine for peak identification A CRS

CAS: 125317-39-7

• Colore e forma: Powder

Vinorelbine tartrate CRS

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈
• Colore e forma: Powder
• Peso molecolare: 778.9323

Vinorelbine Tartrate

CAS: 125317-39-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Formula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆
• Colore e forma: Powder
• Peso molecolare: 778.39416

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

CAS: 125317-39-7

• Formula: C₅₃H₆₇N₄O₂₀
• Colore e forma: Solid
• Peso molecolare: 1080.1139

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purezza: 98%
• Colore e forma: white to off-white solid
• Peso molecolare: 1,079.11g/mol

Vinorelbine Ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Colore e forma: White To Off-White Solid
• Peso molecolare: 778.95 2*150.09

Vinorelbine Ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purezza: >95.0%(T)(HPLC)
• Colore e forma: White to Light yellow powder to crystal
• Peso molecolare: 1,079.12

Vinorelbine Tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Colore e forma: Neat
• Peso molecolare: 1079.11

Vinorelbine Tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈•2C₄H₆O₆
• Purezza: 95%~99%
• Peso molecolare: 1079.11

Vinorelbine tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Colore e forma: Neat
• Peso molecolare: 1079.11

Vinorelbine tartrate, 98%

CAS: 125317-39-7

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₅₃H₆₆N₄O₂₀
• Purezza: 98%
• Colore e forma: White to almost white, Powder
• Peso molecolare: 1079.12

Vinorelbine ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆·xH₂O
• Purezza: (HPLC) ≥ 98.0% (dried basis)
• Colore e forma: White to off-white powder
• Peso molecolare: 1079.11 (anhydrous)

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor …

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purezza: 98% - 99.86%
• Colore e forma: White To Off-White Crystalline Powder
• Peso molecolare: 1079.11

Vinorelbine Bitartrate

CAS: 125317-39-7

Stability Temperature Sensitive Applications An antineoplastic. References Mathe, G., et al.: Cancer Letters, 27, 285 …

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Colore e forma: White
• Peso molecolare: 1079.11

Vinorelbine-d3 Bitartrate

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive Applications An antineoplastic. Not a dangerous good if item is …

• Formula: C₅₃H₆₃D₃N₄O₂₀
• Colore e forma: Neat
• Peso molecolare: 1082.12

Vinorelbine tartrate - Bio-X ™

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life …

• Formula: C₅₃H₆₆N₄O₂₀
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 1,079.11 g/mol

Vinorelbine tartrate

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

• Formula: C₅₃H₆₆N₄O₂₀
• Purezza: (Hplc) Min. 98.0%
• Colore e forma: White Powder
• Peso molecolare: 1,079.11 g/mol