CAS 1257044-40-8

ABT-199

Descrizione:

ABT-199, noto anche come Venetoclax, è un inibitore a piccole molecole progettato principalmente per colpire la proteina del linfoma B 2 (BCL-2), che gioca un ruolo cruciale nella regolazione dell'apoptosi (morte cellulare programmata). Questo composto è caratterizzato dalla sua capacità di legarsi selettivamente a BCL-2, promuovendo così l'apoptosi delle cellule tumorali che sovraesprimono questa proteina, in particolare in alcuni tipi di neoplasie ematologiche come la leucemia linfocitica cronica (LLC) e la leucemia mieloide acuta (LMA). ABT-199 mostra un alto grado di specificità per BCL-2 rispetto ad altre proteine della famiglia BCL-2, il che contribuisce alla sua efficacia terapeutica e al profilo di sicurezza. La sostanza viene somministrata per via orale ed è stata associata a vari effetti collaterali, tra cui neutropenia e sindrome da lisi tumorale, richiedendo un attento monitoraggio durante il trattamento. Il suo sviluppo ha segnato un avanzamento significativo nelle terapie mirate contro il cancro, fornendo un approccio innovativo per trattare neoplasie resistenti alle terapie convenzionali. In generale, ABT-199 rappresenta un avanzamento critico nel campo dell'oncologia, in particolare per i pazienti con tumori specifici dipendenti da BCL-2.

Formula: C₄₅H₅₀ClN₇O₇S

InChI: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

InChI key: InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N

SMILES: C(C1=C(CC(C)(C)CC1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC(OC=5C=C6C(=NC5)NC=C6)=C(C(NS(=O)(=O)C7=CC(N(=O)=O)=C(NCC8CCOCC8)C=C7)=O)C=C4

Sinonimi:

• 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
• Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
• Gdc-0199
• Rg 7601
• Rg7601
• Venclexta
• Venclyxto
• Venetoclax
• ABT 199
• 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide
• GDC0199
• ABT199,GDC0199
• 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide ABT-199 (GDC-0199)

4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(oxan-4-ylmethyl)amino]benzene}sulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide

CAS: 1257044-40-8

Formula: C₄₅H₅₀ClN₇O₇S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 868.4392

Ref: IN-DA000OIU

Venetoclax

CAS: 1257044-40-8

Formula: C₄₅H₅₀ClN₇O₇S

Colore e forma: Yellow Solid

Peso molecolare: 868.45

Ref: 4Z-V-064001

Venetoclax

CAS: 1257044-40-8

Venetoclax

Purezza: ≥98%

Peso molecolare: 868.44g/mol

Ref: 54-BUP16820

Venetoclax-d8 (piperazine-d8)

CAS: 1257044-40-8, 1257051-06-1

Purezza: 98 atom % D

Peso molecolare: 875.36

Ref: 3U-D8267

Venetoclax

CAS: 1257044-40-8

Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48/245 nM).

Formula: C₄₅H₅₀ClN₇O₇S

Purezza: 98.00% - 99.97%

Colore e forma: Solid

Peso molecolare: 868.44

Ref: TM-T2119

Venetoclax

CAS: 1257044-40-8

Formula: C₄₅H₅₀ClN₇O₇S

Peso molecolare: 868.45

Ref: ST-EA-CP-V17000

ABT 199 (>99%)(Venetoclax)

Prodotto controllato

CAS: 1257044-40-8

Applications ABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Formula: C₄₅H₅₀ClN₇O₇S

Colore e forma: Light Yellow To Yellow

Peso molecolare: 868.44

Ref: TR-A112425

ABT 199 (Venetoclax)

Prodotto controllato

CAS: 1257044-40-8

Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Formula: C₄₅H₅₀ClN₇O₇S

Colore e forma: Light Yellow To Yellow

Peso molecolare: 868.44

Ref: TR-A112430

Venetoclax

CAS: 1257044-40-8

A BCL-2 selective inhibitor with no effect on Bcl-xl and thereby prevents thrombocytopenia. Increased sensitivity observed in Bcl-2-dependent haematological tumour cell lines. Elicits additional benefits to tamoxifen treatment in ER-positive breast cancer xenografts.

Formula: C₄₅H₅₀ClN₇O₇S

Purezza: Min. 98 Area-%

Colore e forma: Yellow Powder

Peso molecolare: 868.44 g/mol

Ref: 3D-FV63222

ABT-199-D10

Prodotto controllato

CAS: 1257044-40-8

Applications ABT-199-D10 is a deuterized form of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumor activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

Formula: C₄₅D₁₀H₄₀ClN₇O₇S

Colore e forma: Neat

Peso molecolare: 878.5

Ref: TR-A112432