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CAS 12627-35-9

:

Penitrem A

Descrizione:
Penitrem A è una micotossina prodotta da alcune specie di funghi, in particolare del genere Penicillium. È caratterizzata dalla sua complessa struttura policiclica, che include più anelli fusi e vari gruppi funzionali, contribuendo alla sua attività biologica. Questo composto è noto per i suoi effetti neurotossici, che colpiscono principalmente il sistema nervoso centrale dei mammiferi. Penitrem A è stato studiato per il suo potenziale di indurre tremori e convulsioni negli animali, evidenziando la sua importanza in tossicologia. È solubile in solventi organici, il che facilita la sua estrazione da materiali contaminati. A causa della sua natura tossica, Penitrem A presenta rischi in contesti agricoli, in particolare in relazione a mangimi e prodotti alimentari contaminati. Le agenzie di regolamentazione monitorano la sua presenza per garantire la sicurezza delle forniture alimentari. La ricerca continua a esplorare i suoi meccanismi d'azione e le potenziali implicazioni per la salute umana, così come il suo impatto ambientale. In generale, Penitrem A serve come un esempio critico dell'importanza di comprendere le micotossine sia in contesti ecologici che sanitari.
Formula:C37H44ClNO6
InChI:InChI=1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
InChI key:InChIKey=JDUWHZOLEDOQSR-JKPSMKLGSA-N
SMILES:O[C@]12[C@]34[C@](O3)([C@@H](O)[C@@H](C(C)=C)O[C@]4(CC[C@]1(C)[C@@]5(C)C6=C7[C@]([C@@]5(CC2)[H])(OC(C)(C)[C@@]8([C@@]9(O)C%10=C7C(N6)=CC(Cl)=C%10CC(=C)[C@]9(C8)[H])[H])[H])[H])[H]
Sinonimi:
  • (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
  • (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8S,9aR,14bS,14cR,16aS)-12-chloro-14b,14c,17,17-tetramethyl-10-methylidene-2-(prop-1-en-2-yl)-3,3a,6,6a,7,8,9,9a,10,11,14,14b,14c,15,16,16a-hexadecahydro-2H,4bH-7,8-(epoxymethano)cyclobuta[5,6]benzo[1,2-e]oxireno[4',4a']chromeno[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H)-triol
  • (2R,3S,3aS,4aR,4bS,6aR,7S,8S,9aR,14bS,14cR,16aS)-12-chloro-14b,14c,17,17-tetramethyl-10-methylidene-2-(prop-1-en-2-yl)-3,3a,6,6a,7,8,9,9a,10,11,14,14b,14c,15,16,16a-hexadecahydro-2H,4bH-7,8-(epoxymethano)cyclobuta[5,6]benzo[1,2-e]oxireno[4',4a']chromeno[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H)-triol
  • 7,8-(Epoxymethano)-2H,4bH-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole, penitrem A deriv.
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, [2R-(2α,3α,3aα,4aS*,4bβ,6aα,7α,7dβ,8β,9aβ,14bβ,14cα,16aβ)]-
  • NSC 354845
  • Penitrem A
  • Tremortin A
  • [2R-(2α,3α,3aα,4aS*,4bβ,6aα,7α,7dβ,8β,9aβ,14bβ,14cα,16aβ)]-12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Ordinare per
Purezza (%)
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100
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90
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95
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100
5 prodotti.
  • Penitrem A
    Glentham
    + Info

    Penitrem A

    CAS:
    Formula:C37H44ClNO6
    Peso molecolare:634.20

    Ref: 7W-GP4643

    ne
    Prezzo su richiesta
  • Penitrem A from Penicillium paxilli
    Apollo Scientific
    + Info

    Penitrem A from Penicillium paxilli

    CAS:
    Penitrem A from Penicillium paxilli
    Formula:C37H44ClNO6
    Purezza:By hplc: 97.53% (Typical Value in Batch COA)
    Colore e forma: white powder
    Peso molecolare:634.20g/mol

    Ref: 54-BIP1006

    1mg
    97,00€
    5mg
    300,00€
    10mg
    521,00€
    25mg
    1.120,00€
    50mg
    1.854,00€
    100mg
    3.334,00€
  • Penitrem A
    Targetmol
    + Info

    Penitrem A

    CAS:
    <p>Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.</p>
    Formula:C37H44ClNO6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:634.2

    Ref: TM-T12403

  • Penitrem A, Penicillium paxilli
    Fluorochem
    + Info

    Penitrem A, Penicillium paxilli

    CAS:
    <p>M02244 - Penitrem A, Penicillium paxilli</p>
    Formula:C37H44ClNO6
    Purezza:>90%
    Peso molecolare:634.21

    Ref: 10-M02244

    1mg
    127,00€
  • Penitrem A
    Biosynth
    + Info

    Penitrem A

    CAS:
    <p>Penitrem A is a potent mycotoxin, which is a secondary metabolite produced predominantly by the fungi of the genus *Penicillium*, particularly *Penicillium crustosum*. It operates primarily as a tremorgenic compound, affecting the neuromuscular systems through interference with neurotransmitter release mechanisms. Penitrem A achieves this by blocking calcium channels and modulating the function of neurotransmitter release sites at nerve terminals, leading to its characteristic effects on the nervous system.</p>
    Purezza:Min. 95%

    Ref: 3D-BP162742

    1mg
    303,00€
    5mg
    989,00€
    10mg
    1.491,00€